V. Therapeutic potential of nitric oxide  donors and inhibitors

Muscará, Marcelo Nícolas; Wallace, John L.

doi:10.1152/ajpgi.1999.276.6.g1313

Cited by 100 publications

(97 citation statements)

References 21 publications

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“…L-NAME and D-NAME were injected intraperitoneally (i. p.), at a dose of 50 mg/kg, 24 h and 30 min before venom injection [20]. Aminoguanidine, an inhibitor of iNOS [22], was administered i. p. 24 h and 30 min before venom injection, at doses of 50 mg/kg and 100 mg/kg, respectively [20]. Sodium nitroprusside was used in experiments dealing with edema and myonecrosis, and was injected subcutaneously (s.c.) (for edema) and intramuscularly (i. m.) (for myonecrosis), at a dose of 5 mg/kg.…”

Section: Protocols Used For Administration Of Drugsmentioning

confidence: 99%

Role of nitric oxide in the local and systemic pathophysiological effects induced by Bothrops asper snake venom in mice

2006

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Abstract.Objective: To assess the role of nitric oxide in the most relevant local and systemic manifestations in mice injected with the venom of the snake Bothrops asper. Mice were pretreated with nitric oxide synthase inhibitors, and the modifi cations of the pathological effects induced by the venom were tested. Results: Inhibition of NO synthesis did not affect acute local myonecrosis and hemorrhage in muscle tissue upon intramuscular injection of venom. Local footpad edema was reduced in mice pretreated with the NO synthase inhibitor L-NAME, and a reduction in the extent of infl ammatory infi ltrate in muscle tissue was observed after envenomation in mice pretreated with L-NAME and aminoguanidine. The most pronounced effect of NOS inhibition by L-NAME was an increment in the lethal activity of the venom, when injected by the intraperitoneal route. Conclusion: Nitric oxide does not seem to play a signifi cant role in the local acute pathological alterations (hemorrhage and myonecrosis) induced by B. asper venom in mice, although it contributes to edema and infl ammatory infi ltrate. Nitric oxide exerts a protective role in the systemic pathophysiological manifestations leading to lethality.

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Section: Protocols Used For Administration Of Drugsmentioning

confidence: 99%

Role of nitric oxide in the local and systemic pathophysiological effects induced by Bothrops asper snake venom in mice

2006

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“…Previous researches were in agreement with our results showing that γ-irradiation may enhance endogenous NO biosynthesis in liver, intestine, lung, kidney, brain, spleen or heart of the animals, presumably by facilitating the entry of Ca2+ ions into the membrane as well as the cytosol of NO-producing cells through irradiation induced membrane lesions (Hong et al, 2013). Conversely, it has been demonstrated that NO donors can ameliorate the intestinal injuries in experimental colitis on the basis that NO might inhibit neutrophil infiltration (an important step in the development of I/R injury) and improve microcirculation resulting from its vasodilatory effect (Muscará and Wallace, 1999). .…”

Section: Discussionmentioning

confidence: 99%

The protective effect of Catechin and Rutin on cigarette smoke extract-induced injury in irradiated rats

et al. 2017

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T HE present study was designed to investigate the possible protective effects of catechin and rutin and their possible mechanisms of action in guarding against the oxidative stress and inflammation induced by ionizing radiation and/ or cigarette smoke extract in rats. Exposure of rats to acute doses of γ-radiation or administration of cigarette smoke extract (CSE) in this study were found to exert an oxidative stress due to generation of ROS, which are characterized by elevation in MDA and nitric oxide levels and depletion in reduced glutathione, as well as elevation in MPO activity and level of TNF-α. The results also showed that activities of ALT, AST, ALP, and LDH were increased. Damaging effects were significantly increased in animals exposed to gamma radiation combined with administration of cigarette smoke extract in comparison to either irradiation or administration of cigarette smoke extract. Pretreatment with catechin or rutin largely protected against the change in all the measured parameters. Conclusion: Catechin and rutin might have the potential to modulate the damage induced by radiation exposure in cigarette smoke-treated animals

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“…All these chemical constituents are also present in Neoglaziovia variegata, which probably explains the similarity between the results of these studies. According to Muscara and Wallace (1999), NO is partially involved in mucus and bicarbonate secretion. Sugita et al (2003) reported cytoprotective effects for this compound on ethanol-induced gastric lesions.…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective Effect of an Ethanolic Extract from Neoglaziovia variegata (Arruda) Mez (Bromeliaceae) in Rats and Mice

Machado

Silva

Fernandes

et al. 2013

Zeitschrift Für Naturforschung C

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This study investigates the gastroprotective effect of a crude ethanolic extract of Neoglaziovia variegata (Arruda) Mez (Bromeliaceae), designated Nv-EtOH, in experimental models of gastric ulcer. In the ethanol-induced gastric ulcer model, Nv-EtOH showed gastroprotection at doses of 200 and 400 mg/kg body weight (BW) (57.0% and 79.7%, respectively). Nv-EtOH also signifi cantly reduced the formation of gastric lesions induced by ethanol/HCl (31.6% and 63.5%), ibuprofen (70.0% and 74.3%), or ischemia/reperfusion in rats (65.0% and 87.0%) at 200 and 400 mg/kg BW when compared with the vehicle group. In the antioxidant activity assessment, Nv-EtOH (400 mg/kg BW) increased the catalase activity and sulfhydryl groups (SH) levels, respectively. Moreover, gastroprotection against ethanol damage was decreased after ibuprofen pretreatment. Nv-EtOH (400 mg/kg BW) promoted a signifi cant increase in the content of gastric wall mucus. The Nv-EtOH effect was signifi cantly reduced in mice pretreated with N G -nitro-L-arginine (L-NOARG) or glibenclamide, inhibitors of nitric oxide synthase and K ATP channel activation, respectively, suggesting the involvement of these mechanisms in the Nv-EtOH-induced gastroprotective effect. Nv-EtOH decreased the total acidity, but did not modify other gastric juice parameters. Nv-EtOH was also effective in promoting the healing process in chronic gastric ulcer induced by acetic acid in rats.

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V. Therapeutic potential of nitric oxide donors and inhibitors

Cited by 100 publications

References 21 publications

Role of nitric oxide in the local and systemic pathophysiological effects induced by Bothrops asper snake venom in mice

Role of nitric oxide in the local and systemic pathophysiological effects induced by Bothrops asper snake venom in mice

The protective effect of Catechin and Rutin on cigarette smoke extract-induced injury in irradiated rats

Gastroprotective Effect of an Ethanolic Extract from Neoglaziovia variegata (Arruda) Mez (Bromeliaceae) in Rats and Mice

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