V(D)J recombination of chromosomally integrated, wild-type deletional and inversional substrates occur at similar frequencies with no preference for orientation

Shuh, Maureen; Hixson, Douglas C.

doi:10.1016/j.imlet.2004.09.016

Cited by 1 publication

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“…This latter reaction resembles the first step of Ac/Ds alternative transposition in which the 59 and 39 termini of different Ac/Ds elements are used as substrates. In V(D)J recombination, inversional rearrangement is estimated to occur at a frequency~1/20 that of deletional rearrangement (Shuh and Hixson 2005;Jung et al 2006). The excised RSSs produced by either deletional or inversional rearrangements can undergo reinsertion into the genome approximately once per 50,000 V(D)J recombination events (Reddy et al 2006); hence the frequency of reinsertion of RSS following inversional rearrangement would be approximately once per 10 6 V(D)J recombination events.…”

Section: Alternative Transposition and The Formation Of Oncogenic Chrmentioning

confidence: 99%

Alternative Ac/Ds transposition induces major chromosomal rearrangements in maize

Zhang¹,

Yu²,

Pulletikurti³

et al. 2009

Genes Dev.

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Barbara McClintock reported that the Ac/Ds transposable element system can generate major chromosomal rearrangements (MCRs), but the underlying mechanism has not been determined. Here, we identified a series of chromosome rearrangements derived from maize lines containing pairs of closely linked Ac transposable element termini. Molecular and cytogenetic analyses showed that the MCRs in these lines comprised 17 reciprocal translocations and two large inversions. The breakpoints of all 19 MCRs are delineated by Ac termini and characteristic 8-base-pair target site duplications, indicating that the MCRs were generated by precise transposition reactions involving the Ac termini of two closely linked elements. This alternative transposition mechanism may have contributed to chromosome evolution and may also occur during V(D)J recombination resulting in oncogenic translocations.[Keywords: V(D)J recombination; chromosome rearrangements; hAT elements; transposition] Supplemental material is available at http://www.genesdev.org.

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Section: Alternative Transposition and The Formation Of Oncogenic Chrmentioning

confidence: 99%

Alternative Ac/Ds transposition induces major chromosomal rearrangements in maize

Zhang¹,

Yu²,

Pulletikurti³

et al. 2009

Genes Dev.

View full text Add to dashboard Cite

show abstract

V(D)J recombination of chromosomally integrated, wild-type deletional and inversional substrates occur at similar frequencies with no preference for orientation

Cited by 1 publication

References 94 publications

Alternative Ac/Ds transposition induces major chromosomal rearrangements in maize

Alternative Ac/Ds transposition induces major chromosomal rearrangements in maize

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