Uveitis-like syndrome and iris transillumination after the use of oral moxifloxacin

Bettink-Remeijer, Marijke Wefers; Brouwers, Koos; Langenhove, L Van; Waard, Peter W.T. de; Missotten, Tom; Ciriano, José P. Martinez; Aken, Elisabeth Van

doi:10.1038/eye.2009.234

Cited by 64 publications

(62 citation statements)

References 6 publications

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“…Ayrıca kornea endotelinde inflamatuar keratik presipitatlar, ön kamarada ve vitreusta inflamatuvar hücre-ler mevcuttur (12) . Oral moksifloksasin kullanımı sonrası iris transillimunasyonu ve persistan midriyazis ile üveit benzeri bir tablo gelişebilir (13) . Tranos et al (14) yayınladığı bir olgu sunumunda oral klaritromisin kullanımı sonrası bilateral diffüz iris atrofisi gelişen bir hastadan söz etmiştir.…”

Section: Introductionunclassified

Bilateral acute depigmentation of iris: A report of two cases

Ersöz¹,

Doğan²,

Nacaroğlu³

et al. 2016

Terh

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ÖZBilateral akut iris depigmentasyonu ön kamarada pigment dispersiyonu, iris depigmentasyonu ve diskolorasyonu, inflamatuvar kompanentlerin bulunmaması ve ön kamara açısında pigment birikimi ile karakterize yeni tanımlanmış bir tablodur. Bu çalışmada kliniğimize birer hafta arayla kızarıklık, ağrı ve ışık hassasiyeti yakınmalarıyla başvuran ve bilateral akut iris depigmentasyonu tanısı konulan 24 ve 22 yaşlarında iki kadın olgunun seyrini sunmayı amaçladık. İki olgunun muayene bulguları benzerdi. Biomikroskopide bilateral konjonktival hiperemi, kornea endotelinde iris pigmentleri, ön kamarada yüzen iris pigmentleri, kolaret ile iris kökü arasında diffüz iris depigmentasyonu mevcuttu. Hastaların gonioskopisinde ön kamara açısında yaygın pigment birikimi olduğu görüldü. Aközde inflamatuar hücre, posterior sineşi, iris transilluminasyon defekti, lens ön kapsül-ünde pigment birikimi izlenmedi. Sekiz aylık takip süresince nüks izlenmedi. İris depigmentasyon alanlarında repigmentasyon başladı. Olgu 1'de repigmentasyon sırasında sağ gözde iris nevüsü gelişti. Bilateral akut iris depigmentasyonu, iridosiklitler, pigment dispersiyonu yapan hastalıklar ve iris atrofisinin görüldüğü durumlarla karışabilmektedir. Bu hastalıkların ayrıcı tanısı yapılırken kesinlikle bilateral akut iris depigmentasyonu da göz önünde bulundurulmalıdır. Anahtar kelimeler: iridosiklit, iris atrofisi, iris depigmentasyonu, pigment dispersiyonu ABSTRACTBilateral acute depigmentation of the iris is a new condition characterized by pigment dispersion in the anterior chamber, iris depigmentation and lack of inflammatory components. We report two female cases aged 24 and 22 years who presented at two weekintervals with redness, pain, photophobia and diagnosed as bilateral acute depigmentation of the iris. Ocular examinations of two cases were similar. Bilateral conjunctival hyperemia iris pigment precipitates on the cornea endothelium, floating iris pigment deposits in the anterior chamber and diffuse iris depigmentation between collarette and iris root were seen. In gonioscopic examination of patients, there was diffuse pigment deposition in the anterior chamber. Inflammatory cells in aqueous humour, posterior synechiae, iris transillumination defect or pigment deposition on the anterior capsule of lens weren't detected. During 8 months of follow-up any incident of recurrence was not detected. Iris repigmentation started on areas of iris depigmentation. A new iris nevus developed on the right eye of Case 1. Bilateral acute depigmentation of the iris may be misdiagnosed as iridocyclitis and the conditions with pigment dispersion or iris atrophy. Bilateral acute depigmentation of the iris should be definitely considered in the differential diagnosis of these conditions.

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Section: Introductionunclassified

Bilateral acute depigmentation of iris: A report of two cases

Ersöz¹,

Doğan²,

Nacaroğlu³

et al. 2016

Terh

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“…Previous cases have been reported in Turkey (5,6) (51 cases), Netherlands (3,7) (4 cases), Belgium (3,4,6) (4 cases), Spain (2) (one case) and France (8) (one case). We describe the first reported case in the Southern Hemisphere.…”

Section: Introductionmentioning

confidence: 99%

“…Patients typically present with acute and usually severe photophobia, red eye, and ocular discomfort or pain, which sometimes simulates acute bilateral iridocyclitis. Cases often occur after a flulike illness or upper respiratory tract infection, some of them after the use of oral moxifloxacin (2)(3)(4) . Middle-aged women are most commonly affected.…”

Section: Introductionmentioning

confidence: 99%

Bilateral acute depigmentation of the iris (BADI): first reported case in Brazil

Maestrini¹,

Maestrini²,

Machado³

et al. 2013

Arq. Bras. Oftalmol.

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“…[1][2][3] A few studies have reported other diseases presenting with pigment dispersion and iris transillumination defects. [4][5][6] However, no previous report shows active discharge from an iris epithelial cyst. We describe a case with unusual clinical characteristics including iris cyst formation and pigment showering that led to iris transillumination as well as pupil distortion.…”

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confidence: 99%

Recurrent iris cyst discharge

Altan-Yaycıoğlu¹,

Canan²,

Akova³

2012

Journal of Cataract and Refractive Surgery

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A 23-year-old woman with the diagnosis of anterior uveitis in the left eye was referred to our clinic. Circumferential midzonal iris epithelial cysts were observed in the right eye and corneal endothelial pigment precipitates and diffuse pigment discharge in the anterior chamber of the left eye. Topical prednisolone acetate was prescribed. After 2 days, hyperemia and pain decreased in the left eye and started in the right eye. During the following 3 months, the patient experienced 3 similar episodes, which resulted in diffuse pigment deposition in the anterior chamber angles. Intraocular pressure (IOP) elevation was observed after 1 week and 3 weeks in the left eye and right eye, respectively. Topical antiglaucomatous medication was prescribed. Nine months after the last episode, the uncorrected distance visual acuity was 20/20 and the IOP was 15 mm Hg bilaterally. The iris showed diffuse transillumination, and the pupils were unresponsive to light.

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Uveitis-like syndrome and iris transillumination after the use of oral moxifloxacin

Abstract: Iris transillumination and sphincter paralysis is a newly recognized adverse effect of oral moxifloxacin therapy.

Cited by 64 publications

References 6 publications

Bilateral acute depigmentation of iris: A report of two cases

Bilateral acute depigmentation of iris: A report of two cases

Bilateral acute depigmentation of the iris (BADI): first reported case in Brazil

Recurrent iris cyst discharge

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