Uveitis and the menstrual cycle

Abstract

Purpose To establish whether there is a variation in the incidence of onset of acute anterior uveitis (AAU) in women during the phases of the menstrual cycle. Methods Prospective open study in women attending the Acute Referral Centre with a first or recurrent attack of AAU. Results There was a significant increase in the incidence of AAU during the late stages of the menstrual cycle. Conclusions The onset of AAU is partially dependent on the levels of either oestrogen or progesterone, or both. The withdrawal of the proven anti-inflammatory effects of these hormones may provoke the onset of uveitis.

Uveitis and the menstrual cycle

“…We read with interest the article 'Uveitis and the menstrual cycle' by Sanghvi et al 1 In their study, the authors reported the relation between menstrual cycle and patient-reported onset of acute anterior uveitis (AAU), in 76 regularly menstruating women. They concluded that the onset of AAU was partially dependent on the levels of either oestrogen or progesterone, or both.…”

The Role of Estradiol in Idiopathic Anterior Uveitis during the Eumenorrheic Stage of Life

“…(Tables 1-2) The difference in uveitis course may relate to the unique sexual hormone milieu of each group. [9] This may correspond to monthly female sex hormone fluctuations during the menstrual cycle in eumenorrheic patients. We also demonstrated an average severity of uveitis flare-up that was more intense in eumenorrheic compared to postmenopausal women.…”

“…[5][6][7][8] Acharya et al demonstrated that women have been reported to demonstrate more uveitis relapses during the premenstrual and menstrual phases of their cycles. [9] In addition, on our Uveitis Service we have observed that many pregnant women did not relapse during the course of their pregnancy, and instead experienced a severe relapse two to four months after giving Women with idiopathic anterior uveitis do not appear to relapse while pregnant. Relapses are reported more frequently and intensely during premenstrual and menstrual stages.…”

Cambios en la película lagrimal con el uso simultáneo de lentes de contacto y tratamientos anticonceptivos hormonales

“…Actualmente se dispone de métodos anticonceptivos hormonales y mecánicos, de administración oral, subcutánea o vaginal (6). Los anticonceptivos que contienen progestina y estrógenos (hormonas presentes en el cuerpo) se encuentran al interior del sistema visual y ocular en el humor acuoso, la glándula lagrimal, las glándulas de Meibomio (GM), el párpado, la conjuntiva bulbar y palpebral, la córnea y la úvea anterior y posterior (7). Existen evidencias que afirman que las glándulas lagrimales y los tejidos superficiales del ojo son sensibles a los cambios en el nivel de estrógenos circulante (8), lo que disminuye el tiempo de rompimiento de la película lagrimal (BUT) y la secreción meibomiana.…”