UVA-induced neurotoxicity in Japanese medaka (Oryzias latipes)

Sayed, Alaa El‐Din H.; Soliman, Hatem; Mikami, Hiroshi

doi:10.1039/c8pp00169c

Cited by 7 publications

(6 citation statements)

References 34 publications

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“…Our result was suitable in compliance with the results found by Hamed et al (2020) that the disclosure of microplastics may induce antioxidant damage in N. Tilapia (O. niloticus). The examined behaviors of antioxidant enzyme activity were in agreement with the results reported previously in studies involving different species exposed to heavy metal (Pedrajas et al, 1995;Paris-Palacios et al, 2000;Vieira et al, 2009;Wang et al, 2009;Tang et al, 2013;Hamed et al, 2019a;Sayed et al, 2019;Soliman et al, 2019;Sayed et al, 2021a;Sayed et al, 2021b;Soliman et al, 2021;Sayed et al, 2022). It has been reported in another study that the most significant finding was that the REE accumulated in zebra tissue after REE exposure was highly correlated to cytochrome c oxidase (CO1) and superoxide dismutase (SOD) were increased, while gene expressions of catalase (CAT) and glutathione-S-transferase (GST) were decreased (Hanana et al, 2017).…”

Section: Discussionsupporting

confidence: 90%

“…Higher enzyme levels are detected from the blood samples test, such as lactic dehydrogenase, AST, ALT, creatine kinase, and alkaline phosphatase, which correspond to damage to cell membranes (Banaee 2013). Such results are in agreement with other reported findings (Gill et al, 1992;Kazlauskienė and Stasiunaitė 1999;Monteiro et al, 2005;Heydarnejad et al, 2013;Pretto et al, 2014;Abdel-Khalek et al, 2015;Hamed et al, 2019a;Hamed et al, 2019b;Osman et al, 2019;Sayed et al, 2019;Soliman et al, 2019;Sayed et al, 2021a;Sayed et al, 2021b;Soliman et al, 2021;Hamed et al, 2022;Sayed et al, 2022). The variation in glucose levels is related to the glycogenolysis and gluconeogenesis processes occurring in the liver and kidney (Oner et al, 2008).…”

Section: Discussionsupporting

confidence: 87%

“…These indices were selected because they are the first route for pollutants and the most sensitive tissue to detect side effects and pathology. Besides nuclear damage, apoptosis, and micronuclei abnormalities, fish erythrocyte distortion was considered in toxicological studies as a sign of pollution (Mekkawy et al, 2011;Sayed et al, 2016a;Sayed et al, 2019;Talapatra and Banerjee, 2005). Based on this point of view, this work aims to explore the effects of igneous rock powder on Nile tilapia juveniles using hematobiochemical parameters, erythrocyte alterations, and antioxidant biomarkers as endpoints.…”

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confidence: 99%

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Effects of major and trace elements from the El Kahfa ring complex on fish: Geological, physicochemical, and biological approaches

Saad

Hamed²,

Elshahawy³

et al. 2023

Front. Environ. Sci.

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The alkaline rocks are known for enriching rare lithophilic elements, including lithium, uranium, and tin, which negatively impact aquatic life. This study offers an intensive investigation of the influence of alkaline rocks on Nile Tilapia (Oreochromis niloticus). The variation in blood profile, the induction of antioxidant enzymes, morphological erythrocyte, and histological structure have been conducted for the fish after 15 days of exposure to alkaline rocks powder with a dose of 100 μg/L. As a result, there was a pronounced decrease in blood profiles, such as platelets and white blood cell counts. There was a failure in the liver and kidney functions. Moreover, it shows an increase in superoxide dismutase (SOD) and catalase (CAT) activities as antioxidant biomarkers. Also, exposure to alkaline rocks induced DNA mutation and erythrocyte distortion. We concluded that the bulk alkaline rocks induced changes in the hemato-biochemical and antioxidant parameters of Nile tilapia. Additionally, exposure to bulk alkaline rock compounds also caused poikilocytosis and nuclear abnormalities of RBCs. This draws our attention to the seriousness of climatic changes, the erosion of rocks, and their access to water.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 87%

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confidence: 99%

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Effects of major and trace elements from the El Kahfa ring complex on fish: Geological, physicochemical, and biological approaches

Saad

Hamed²,

Elshahawy³

et al. 2023

Front. Environ. Sci.

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“…Different blood cell indices, including hemotoxicity and biochemistry, are used as major biomarkers of systemic responses to environmental stress in fish ( Mekkawy et al, 2011 ; Abou Khalil et al, 2017 ; Sayed and Soliman, 2018 ). In addition to apoptosis, micronucle and nuclear abnormalities, fish erythrocyte deformations have also been considered in toxicological studies on pollution-stress responses ( Talapatra and Banerjee, 2007 ; Mekkawy et al, 2011 ; Sayed et al, 2016a , 2019b ). Because the brain and spinal cord play an essential role in fish physiology, the brain tissue is often studied in fish toxicology ( Sayed et al, 2019b ).…”

Section: Introductionmentioning

confidence: 99%

“…In addition to apoptosis, micronucle and nuclear abnormalities, fish erythrocyte deformations have also been considered in toxicological studies on pollution-stress responses ( Talapatra and Banerjee, 2007 ; Mekkawy et al, 2011 ; Sayed et al, 2016a , 2019b ). Because the brain and spinal cord play an essential role in fish physiology, the brain tissue is often studied in fish toxicology ( Sayed et al, 2019b ). It is postulated that brain biomarkers may be effective for pollution biomonitoring and may provide warning signals of pollutant exposure ( Ferrando and Andreu-Moliner, 1991 ; Tabassum et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Reproductive Toxicity and Recovery Associated With 4-Non-ylphenol Exposure in Juvenile African Catfish (Clarias garepinus)

et al. 2022

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Although, the effects of 4-non-ylphenol (4-NP) on fish’s reproductive hormones were assessed in several studies using adult models, however, the effect of this endocrine disruptor on immature fish’s reproductive hormones was not addressed commonly. We aimed to study the apoptosis induction, hematotoxicity, reproductive toxicity, and the recovery associated with 4-NP exposure in juvenile African catfish [Clarias garepinus) using some hormones [17β-estradiol (E2), testosterone (T), follicle-stimulating hormone (FSH), and luteinizing hormone (LH)] and gonad histology as biomarkers. The toxic effects of 4-NP have been studied in many animal models, but there is still limited knowledge about the dose-dependent damage caused by 4-NP exposure in juvenile Clarias gariepinus. A healthy juvenile C. gariepinus was categorized into four groups (n = 3/group; three replicates in each group). The first group was the control, and the other three groups were subjected to 4-NP concentrations as 0.1, 0.2, and 0.3 mg/L for 15 days; they were left for a recovery period of another 15 days. The reproductive hormones of C. gariepinus exposed to 4-NP for 15 days exhibited significant variations between the treatment groups and the control (P < 0.05), which were evident in E2 and T-values, whereas FSH, LH, total protein, and lipid peroxidation values showed non-significant differences among all groups at P < 0.05. Such a situation referred to the fact that the 15-day recovery period was insufficient to remove the impacts of 4-NP doses in concern. The trend of dose-dependent increase/decrease was recorded for T, E2, FSH, and LH. The histopathological alterations of 4-NP treated in gonad tissues were recorded in juvenile C. gariepinus, reflecting their sensitivity to 4-NP estrogenic-like effects. Overall, our results investigate that recovery has improved the reproductive toxicity caused by 4-NP in juvenile C. garepinus. Significant variations between the treated groups and the control group (P < 0.05) were evident in hematological parameters except for hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC). The parameters exhibiting significance decreased with such increased doses [red blood cells (RBCs), hematocrit (Hct), and white blood cells (WBCs)]. Similar patterns of significant variations toward the increase or decrease were recorded following the 15-day recovery period. Apoptotic frequency in erythrocytes and brain cells has increased significantly with increased 4-NP exposure, indicating that 4-NP caused cytotoxic effects, such as apoptosis in a dose-dependent manner. However, these cellular alterations greatly decreased after the 15-day recovery period.

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Effect of ultraviolet radiation (UVR) on the life stages of fish

Alves

Agustı́

2020

Rev Fish Biol Fisheries

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Current levels of Ultraviolet Radiation (UVR) represent a significant threat to many fish species. The first studies on the effects of UVR on organisms were performed on fish at the beginning of the twentieth century, and the topic has been progressing continuously until the present. Here, we review the reported harmful effects of ultraviolet B (UVB) and A (UVA) radiations in fish at different lifecycle stages, including embryo, larvae, juveniles and adults. The most evident negative effects during the early development stages are an increase in mortality and incidence in developmental malformations, with the skin and gills the most affected tissues in larvae. Growth reduction, a loss in body condition, and behavioral, physiological and metabolic changes in juveniles/adults occur under short- or long-term UVB exposure. The skin in juveniles/adults undergoes profound morphological and functional changes, even after acute exposure to UVR. Impairment of molecular and cellular processes was evidenced in all development stages by increasing the levels of DNA damage, apoptosis and changing tissues’ antioxidant status. The different photo-protective mechanisms to cope with excessive UVR exposure are also revised. Currently, stratospheric ozone dynamics and climate change interact strongly, enhancing the potential exposure of fish to UVR under water. Due to these environmental changes, fish are exposed to new and complex interactions between UVR and environmental stressors, which potentially affects fish growth and survival. Understanding the ability of fish to cope and adapt to these environmental changes will be essential to evaluate the potential impact in fisheries and mitigate ecological problems.

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UVA-induced neurotoxicity in Japanese medaka (Oryzias latipes)

Abstract: Ultraviolet radiation-induced neurodegeneration has been studied in the early stages of development in fish, but not extensively in the adult stage.

Cited by 7 publications

References 34 publications

Effects of major and trace elements from the El Kahfa ring complex on fish: Geological, physicochemical, and biological approaches

Effects of major and trace elements from the El Kahfa ring complex on fish: Geological, physicochemical, and biological approaches

Reproductive Toxicity and Recovery Associated With 4-Non-ylphenol Exposure in Juvenile African Catfish (Clarias garepinus)

Effect of ultraviolet radiation (UVR) on the life stages of fish

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