UVA- and UVB-induced changes in hairless mouse skin collagen

Trautinger, Franz; Mazzucco, K.; Knobler, Robert; Trenz, A.; Kokoschka, E. M.

doi:10.1007/bf00371578

Cited by 42 publications

(26 citation statements)

References 19 publications

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“…The use of cryostat tissue sections on glass slides made it possible to readily analysis the content of hydroxyproline (μg/mm 2 ) in the skin. It was reported that the amount of soluble collagen in hairless mice skin exposed to UV irradiation markedly decreased (23). Overall, these results demonstrated that application of xanthine derivates markedly prevented decrease in total collagen and accumulation of pepsin‐resistant collagen, and suppressed the alteration of collagen bundles in the dermis.…”

Section: Discussionmentioning

confidence: 99%

Topical application of plant extracts containing xanthine derivatives can prevent UV‐induced wrinkle formation in hairless mice

Mitani

Ryu

Suzuki

et al. 2007

Photoderm Photoimm Photomed

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Section: Discussionmentioning

confidence: 99%

Topical application of plant extracts containing xanthine derivatives can prevent UV‐induced wrinkle formation in hairless mice

Mitani

Ryu

Suzuki

et al. 2007

Photoderm Photoimm Photomed

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“…Immunohistochemical staining of collagen fibers has demonstrated a sparse distribution in areas of solar elastosis , in contrast to the normally dense, almost confluent, organization of collagen fibers found in the superficial dermis 9 . Collagen type I has been found to be diminished in photoaged skin 13,14 . Data suggest that the decrease in collagen content in photoaged skin is a result of increased collagen degradation, whereas collagen production remains the same 15 .…”

Section: Skin Agingmentioning

confidence: 98%

Molecular Mechanisms of Skin Aging

Makrantonaki

Zouboulis

2007

Annals of the New York Academy of Sciences

230

154

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The process of skin aging in humans is complex and is induced by multiple factors, including genetic and various environmental ones. In particular, the superposition of environmental factors, such as UV irradiation on skin, results in massive wound-like morphological alterations mainly of the dermis. In sun-protected areas the most pronounced changes occur within the epidermis and affect mostly the basal cell layer. As a result, while sun-protected aged skin appears thin, finely wrinkled, and dry, photoaged skin is characterized by deep wrinkles, laxity, and roughness. Although the fundamental mechanisms are still poorly understood, a growing body of evidence points toward the involvement of multiple pathways in the generation of aged skin. Recent data obtained by expression-profiling studies and studies of progeroid syndromes (e.g., Hutchinson-Gilford progeria, Werner syndrome, Rothmund-Thomson syndrome, Cockayne syndrome, ataxia teleangiectasia, and Down syndrome) illustrate that among the most important biological processes involved in skin aging are alterations in DNA repair and stability, mitochondrial function, cell cycle and apoptosis, ubiquitin-induced proteolysis, and cellular metabolism. One of the major factors that has been proposed to play an exquisite role in the initiation of aging is the physiological hormone decline occurring with age. However, hormones at age-specific levels may not only regulate age-associated mechanisms but also regulate tumor-suppressor pathways that influence carcinogenesis. Understanding the molecular mechanisms of aging may open new strategies in dealing with the various diseases accompanying aging, including cancer.

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“…28 The majority of UVB and approximately 35% of UVA is absorbed by ocular surface tissues. 29 While potential downstream influences of UVB-induced DNA damage and mutations should not be minimized, UVA is established as a cause of collagen cross-linking, 28, 30, 31 with altered collagen structure often permanently changing the functionality of affected tissue. 32 In fact, the excitation wavelengths for conjunctival ultraviolet autofluorescence in the present study were in the UVA range (320 to 380nm), previously found to be associated with collagen cross-linking autofluorescence in human skin.…”

Section: Discussionmentioning

confidence: 99%

Seasonal Effect on Ocular Sun Exposure and Conjunctival UV Autofluorescence

Haworth¹,

Chandler

2017

Optom Vis Sci

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Purpose To evaluate feasibility and repeatability of measures for ocular sun exposure and conjunctival ultraviolet autofluorescence (UVAF), and to test for relationships between the outcomes. Methods Fifty volunteers were seen for 2 visits 14±2 days apart. Ocular sun exposure was estimated over a two-week time period using questionnaires that quantified time outdoors and ocular protection habits. Conjunctival UVAF was imaged using a Nikon D7000 camera system equipped with appropriate flash and filter system; image analysis was done using ImageJ software. Repeatability estimates were made using Bland-Altman plots with mean differences and 95% limits of agreement calculated. Non-normally distributed data was transformed by either log10 or square root methods. Linear regression was conducted to evaluate relationships between measures. Results Mean (±SD) values for ocular sun exposure and conjunctival UVAF were 8.86 (±11.97) hours and 9.15 (±9.47) mm2, respectively. Repeatability was found to be acceptable for both ocular sun exposure and conjunctival UVAF. Univariate linear regression showed outdoor occupation to be a predictor of higher ocular sun exposure; outdoor occupation and winter season of collection both predicted higher total UVAF. Furthermore, increased portion of day spent outdoors while working was associated with increased total conjunctival UVAF. Conclusions We demonstrate feasibility and repeatability of estimating ocular sun exposure using a previously unreported method and for conjunctival UVAF in a group of subjects residing in Ohio. Seasonal temperature variation may have influenced time outdoors and ultimately calculation of ocular sun exposure. As winter season of collection and outdoor occupation both predicted higher total UVAF, our data suggests that ocular sun exposure is associated with conjunctival UVAF and possibly, that UVAF remains for at least several months following sun exposure.

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UVA- and UVB-induced changes in hairless mouse skin collagen

Cited by 42 publications

References 19 publications

Topical application of plant extracts containing xanthine derivatives can prevent UV‐induced wrinkle formation in hairless mice

Topical application of plant extracts containing xanthine derivatives can prevent UV‐induced wrinkle formation in hairless mice

Molecular Mechanisms of Skin Aging

Seasonal Effect on Ocular Sun Exposure and Conjunctival UV Autofluorescence

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