UV-VIS Curable PEG Hydrogels for Biomedical Applications with Multifunctionality

Sabel‐Grau, Tina; Tyushina, Arina; Babalik, Cigdem; Lensen, Marga C.

doi:10.3390/gels8030164

Cited by 22 publications

(19 citation statements)

References 31 publications

(32 reference statements)

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“…Poly (ethylene glycol) (PEG). PEG-based hydrogels have been promising candidates for biomedical applications in recent decades mainly due to their biocompatibility [ 53 , 140 ]. Moreover, their mechanical properties and chemical composition can be regulated, which allows easily controlling the architecture of the scaffolds, making PEG an interesting material for biomedical applications [ 141 ].…”

Section: Methodsmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

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Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced and solved. Hydrogels have been proposed as excellent candidates for these applications, as they have promising properties for the mentioned applications, including biocompatibility, biodegradability, great absorption capacity and tunable mechanical properties. However, depending on the material or the manufacturing method, the resulting hydrogel may not be up to the specific task for which it is designed, thus there are different approaches proposed to enhance hydrogel performance for the requirements of the application in question. The main purpose of this review article was to summarize the most recent trends of hydrogel technology, going through the most used polymeric materials and the most popular hydrogel synthesis methods in recent years, including different strategies of enhancing hydrogels’ properties, such as cross-linking and the manufacture of composite hydrogels. In addition, the secondary objective of this review was to briefly discuss other novel applications of hydrogels that have been proposed in the past few years which have drawn a lot of attention.

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Section: Methodsmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

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“…A live/dead staining assay has been used to study the cell viability after incubation with PI EB and EY and also EB 0.1% with PEG-DA before and after crosslinking for UV-Vis spectra for the novel PIs (EB and EY) with PEG-DA before and after crosslinking, respectively. The hydrogels with new PIs (EB and EY) exhibit good spectroscopic properties, so they can be used with light sources in the visible range [1].…”

Section: Cytotoxicity Testsmentioning

confidence: 99%

“…Multifunctional biomedical materials capable of integrating optical functions are highly desirable for many applications, such as advanced intra-ocular lens (IOL) implants [1].…”

Section: Introductionmentioning

confidence: 99%

“…The versatile applications of volume holographic materials are numerous and range from recording media, holographic data storage, self-written waveguides and wavelength-selective devices, to solar energy concentrators and diffractive elements for biomedical applications [1,9,18,19]. The long list of potential applications is driving the need for suitable materials for volume holography.…”

Section: Introductionmentioning

confidence: 99%

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Volume Holographic Structuring of Special Hydrogel Films by Photochemical Crosslinking

Sabel‐Grau¹,

Tyushina²,

Rahman³

et al. 2023

Holography - Recent Advances and Applications

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Multifunctional biomedical materials capable of integrating optical functions open up promising new possibilities for the application of photosensitive materials. For example, they are highly desirable for advanced intraocular lens (IOL) implants. For this purpose, we propose hydrogels, based on poly(ethylene glycol) (PEG) prepolymers, which are photochemically crosslinkable and thereby patternable. Various photoinitiators are used and investigated spectroscopically; those with high sensitivity in the optical region of the spectrum are advantageous. Hydrogel films have been obtained, which are applicable for light-based patterning and, hence, for functionalization of both surface and volume: It is shown that a local change in optical properties can be induced in special hydrogel films by photochemical crosslinking. Such a local light-induced material response forms the basis for volume holographic patterning. Cytocompatibility of hydrogels and compositions is evaluated via cytotoxicity tests. Exploiting the interrelationship between structure and function is highly relevant for biomedical materials with multifunctionality.

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“…In the research of volume holographic materials for diverse applications, much emphasis is placed on their design and understanding of the grating formation processes [ 1 ]. The versatile applications are numerous and range from recording media, holographic data storage, self-written waveguides, and wavelength-selective devices, to solar energy concentrators and diffractive elements for biomedical applications [ 2 , 3 , 4 , 5 , 6 , 7 ]. Therefore, new materials for volume holography are constantly being developed and these are being researched in ever greater depth [ 4 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Pre-Exposure on the Material Response of Epoxy-Based Volume Holographic Recording Material

Sabel‐Grau

2022

Polymers

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The formation of volume holograms in photosensitive polymers is a complex process under the influence of many interacting factors: material composition and processing, exposure conditions, and pre-exposure affect the development and final characteristics of holographic gratings. In order to better understand the interplay of these influencing factors, the detailed investigations of holographic recording in a new organic material are performed and the results are presented here. The material response and performance of an epoxy-based free surface material designed for volume holography are investigated. For this purpose, time-resolved investigation of volume holographic grating growth is performed on the one hand. Spatially resolved analysis of volume holographic phase gratings by point-by-point scanning of the local material response to the Gaussian intensity distribution of the recording beams is carried out on the other hand. Thus, the influence of pre-exposure on the temporal grating formation, as well as on the final obtained refractive index contrast, was determined. The various effects observed can be explained by the consumption of photosensitive compounds and prior crosslinking in the course of pre-exposure. Rather unexpected effects are that, on the one hand, pre-exposed gratings emerge with ever more complete null diffraction at the transition point and, on the other hand, a stabilizing effect of some degree of pre-exposure on regions exposed with low intensity was identified.

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UV-VIS Curable PEG Hydrogels for Biomedical Applications with Multifunctionality

Cited by 22 publications

References 31 publications

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Volume Holographic Structuring of Special Hydrogel Films by Photochemical Crosslinking

Influence of Pre-Exposure on the Material Response of Epoxy-Based Volume Holographic Recording Material

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