UV Spectrophotometric Method Development and Validation of Mesalazine in Bulk and Solid Dosage Form (Research Article)

Ghurghure, Shrishail M.; Sawant, Kuldeepkumar; Deokar, Savita S

doi:10.21276/ijpbs.2021.11.1.17

Cited by 2 publications

(1 citation statement)

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“…The results that were obtained showed excellent agreement between the taken and founded amounts with minimal values of percentage error. Recovery values for both FI approaches were contrasted with those attained using the UV method [19]. The proposed and reference procedures were statistically compared using the F and t-tests [20,21], and the computed values were lower than the theoretical ones, pointing to no significant variance between the two methodologies in terms of accuracy and precision (Table 5).…”

Section: Assay Of Mes In Pharmaceutical Formsmentioning

confidence: 99%

Normal and Reverse Flow Injection Analysis Methods for Estimation of Mesalazine in Pharmaceutical Dosage Forms

Hasan,

Hadi

2023

IHJPAS

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Determining the actual amounts of active ingredients in various pharmaceutical commercial forms is still receiving a lot of attention. Two flow injection analysis (FIA) methods were suggested for determination of mesalazine (MES) in pharmaceutical forms. Normal and reverse FIA systems (nFIA and rFIA) combined with UV-Vis spectrophotometric technique were used for the analysis. The methods involved using two mods of FIA systems for measuring a colored product result from coupling of MES with 2,2'-dihydroxybiphenyl after oxidized with sodium periodate in alkaline medium. The absorbance of the red colored dye was measured at maximum wavelength of 500 nm. The calibration graphs for MES were linear in the ranges 2.5-200 and 0.5-60 µg/mL with RSD of best than 3% for both methods respectively. Also the limits of detection were 1.2 and 0.2 µg/mL and limits of quantitation were 3.6 and 0.7 µg/mL of MSL for nFIA and rFIA systems respectively. All physical and chemical conditions of flow systems such as flow rate, reaction coil length and reagent concentrations were carefully studied. The proposed methods were applied for determining MES in four commercial tablets without any interferences.

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Section: Assay Of Mes In Pharmaceutical Formsmentioning

confidence: 99%