UV-Spectrophotometric Estimation of Olopatadine hydrochloride in Bulk and Pharmaceutical Dosage Form by area under Curve and second Order Derivative Methods

Electro‐elucidation and quantification of olopatadine hydrochloride in bulk form and eye drops using modification free glassy carbon electrode with its development by different electrolytes and surfactants

“…Few analytical methods have been reported for the determination of OPH in pharmaceutical formulations and human biological fluids. These include HILC-MS/ MS [3,7], HPTLC [8], RP-HPLC [9][10][11], HPLC-ESI-MS/ MS [12,13], HPLC-MS/TOF [14], potentiometric sensor [15], UV-vis [6,[16][17][18][19][20][21]. The reported chromatographic and spectroscopic tools have many disadvantages such as sample pretreatment, time consuming, expensive apparatus and reagents.…”

A specific high‐performance thin‐layer chromatography method validated for estimation of mometasone furoate and olopatadine hydrochloride

“…Olopatadine is official in Indian Pharmacopeia [2] and United state Pharmacopeia [3]. From the literature review, it is observed that many analytical methods have been developed involving spectrophotometric [4][5][6][7][8][9][10][11][12][13][14], LC [14], HPLC [12,[15][16][17], Volttametry [20], HPTLC [15,[18][19], stability-indicating HPLC method [17] and LC-ESI-MS/MS [21] for the estimation of OLO in pharmaceutical formulations. Mometasone furoate (MOM) Figure 2 F I G U R E 2 Structure of Mometasone Furoate.…”

“…Olopatadine is official in Indian Pharmacopeia [2] and United state Pharmacopeia [3]. From the literature review, it is observed that many analytical methods have been developed involving spectrophotometric[4–14], LC [14], HPLC [12, 15–17], Volttametry [20], HPTLC [15, 18–19], stability‐indicating HPLC method [17] and LC‐ESI‐MS/MS [21] for the estimation of OLO in pharmaceutical formulations. Mometasone furoate (MOM) Figure 2, chemically [(8 S ,9 R ,10 S ,11 S ,13 S ,14 S ,16 R ,17 R )−9‐chloro‐17‐(2‐chloroacetyl)−11‐hydroxy‐10,13,16‐trimethyl‐3‐oxo‐6,7,8,11,12,14,15,16‐octahydrocyclopenta[a]phenanthren‐17‐yl] furan‐2‐carboxylate Topical glucocorticoid receptor (GR) agonist with dermatological properties.…”

An Innovative Spectrophotometric Method for the Estimation of H1 Receptor Antagonists in Pharmaceutical Formulations

“…Olopatadine hydrochloride (HCl) (OLO), 2-[(11Z)-11- [3-(dimethylamino)propylidene]-6H-benzo[c] [1] benzoxepin-2-yl]acetic acid hydrochloride [1] (fig. 1) is a white crystalline powder, almost odourless soluble in double distilled water, methanol and chloroform.…”