UV-specific DNA repair recombinant fusion enzyme: A new stable pharmacologically active principle suitable for photoprotection

Basílico, Guillermo; Roger, Carolina Alvarez; Seigelchifer, Mauricio; Kerner, Nestor

doi:10.1016/j.jdermsci.2005.03.007

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…P. acnes (Cutibacterium acnes), which is described as a player in skin acne, provides protection to skin against other opportunistic pathogen by acidifying the skin [39]. These reductions in relative abundance were significant for Micrococcus, Kocuria and Corynebacterium, members of the most occurring Phylum of Actinobacteria with valuable capacities: Micrococcus luteus (Micrococacceae, Actinobacteria) has protective effect against UV [40]; it is known for producing an enzyme that can repair DNA damages induced by UV [41]. Kocuria genus which is resistant to UV are known to produce antioxidant enzyme such Superoxide dismutase [42]; we cannot exclude that these properties of Kocuria and Micrococcus are beneficial to skin protection and repair after different stresses like UV stress.…”

Section: Discussionmentioning

confidence: 99%

Effect of Sodium Lauryl Sulfate (SLS) Applied as a Patch on Human Skin Physiology and Its Microbiota

Leoty-Okombi¹,

Gillaizeau²,

Leuillet³

et al. 2021

Cosmetics

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In this study, we assessed the change in skin microbiota composition, relative abundance, and diversity with skin physiology disruption induced by SLS patch. Healthy women declaring to have a reactive skin were submitted to a 0.5% aqueous sodium lauryl sulfate solution application under occlusive patch condition for 24 h. Skin properties were characterized by tewametry, corneometry, and colorimetry and bacterial diversity was assessed by 16S rRNA sequencing. Analysis before and one day after SLS patch removal revealed an increase of skin redness and a decrease of stratum corneum hydration and skin barrier function. The relative abundance of taxa containing potential pathogens increase (Firmicutes: Staphylococcaceae; Proteobacteria: Enterobacteriaceae, Pantoea) while some of the most occurring Actinobacteria with valuable skin protection and repair capacities decreased (Micrococcus, Kocuria, and Corynebacterium). We observed an impaired skin barrier function and dehydration induced by SLS patch disturb the subtle balance of skin microbiota towards skin bacterial community dysbiosis. This study provides new insights on the skin bacterial composition and skin physiology simultaneously impaired by a SLS patch.

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Section: Discussionmentioning

confidence: 99%

Effect of Sodium Lauryl Sulfate (SLS) Applied as a Patch on Human Skin Physiology and Its Microbiota

Leoty-Okombi¹,

Gillaizeau²,

Leuillet³

et al. 2021

Cosmetics

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show abstract

“…This metabolite, besides being derived from Streptomyces [74], is known for its photoprotective properties [75]. Interestingly, a UV-specific repair enzyme has been isolated from Micrococcus luteus, which represents another promising alternative to using this bioresource to find photoprotection hits [76]. As expected, in the case of Gordonia and Promicromonospra, no studies investigated their photoprotective potential to our knowledge.…”

Section: Actinomycetes As a Bioresource Of Photoprotectantsmentioning

confidence: 94%

Cliona varians-Derived Actinomycetes as Bioresources of Photoprotection-Related Bioactive End-Products

et al. 2021

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Sunscreen and sunblock are crucial skincare products to prevent photoaging and photocarcinogenesis through the addition of chemical filters to absorb or block ultraviolet (UV) radiation. However, several sunscreen and sunblock ingredients, mostly UV filters, have been associated with human and environmental safety concerns. Therefore, the exploration and discovery of promising novel sources of efficient and safer compounds with photoprotection-related activities are currently required. Marine invertebrates, particularly their associated microbiota, are promising providers of specialized metabolites with valuable biotechnological applications. Nevertheless, despite Actinobacteria members being a well-known source of bioactive metabolites, their photoprotective potential has been poorly explored so far. Hence, a set of methanolic extracts obtained from Cliona varians-derived actinomycetes was screened regarding their antioxidant and UV-absorbing capacities (i.e., photoprotection-related activities). The active extract-producing strains were identified and classified within genera Streptomyces, Micrococcus, Gordonia, and Promicromonospora. This is the first report of the isolation of these microorganisms from C. varians (an ecologically important Caribbean coral reef-boring sponge). The in vitro cytotoxicity on dermal fibroblasts of oxybenzone and the selected active extracts revealed that oxybenzone exerted a cytotoxic effect, whereas no cytotoxic effect of test extracts was observed. Accordingly, the most active (SPFi > 5, radical scavenging > 50%) and nontoxic (cell viability > 75%) extracts were obtained from Streptomyces strains. Finally, LC-MS-based characterization suggested a broad chemical space within the test strains and agreed with the reported streptomycetes’ chemodiversity. The respective metabolite profiling exposed a strain-specific metabolite occurrence, leading to the recognition of potential hits. These findings suggest that marine Streptomyces produce photoprotectants ought to be further explored in skincare applications.

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“…and resulting in skin disease; increased in sensitisation reaction in seborrheic dermatitis patients; and may lead to the development of benign, premalignant, or malignant tumour, morphological change of epithelium cells, organ toxicity (predominantly heart, liver, lungs, and brain), ophthalmic irritation, cataract formation, carcinogenic effect, and hair loss upon long term exposure. [ [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] ] Cocamidopropyl Betaine (CAPB) Surfactant Increased the prevalence rates of allergic contact dermatitis among young children after exposure to baby shampoos containing CAPB; cosmetic-allergic patients experienced scalp itching, inflammation on the ears, neck, and forehead, and developed eczema on the face and neck; and caused dermatological sensitisation upon exposure to impurities in CAPB, such as 3-dimethylaminopropylamine (DMAPA) and amidoamine (AA). [ [18] , [19] , [20] , [21] , [22] ] Ethylene oxide (EtO) Sterilant Increased in the risk of breast and lymphohematopoietic cancer; exerted a genotoxicity effect and increased in prevalence of mortality; and potentially form macromolecular adducts with nucleic acids and proteins and causes mutation.…”

Section: Introductionmentioning

confidence: 99%

Natural alternatives from your garden for hair care: Revisiting the benefits of tropical herbs

Sang,

Akowuah,

Liew

et al. 2023

Heliyon

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UV-specific DNA repair recombinant fusion enzyme: A new stable pharmacologically active principle suitable for photoprotection

Cited by 4 publications

References 22 publications

Effect of Sodium Lauryl Sulfate (SLS) Applied as a Patch on Human Skin Physiology and Its Microbiota

Effect of Sodium Lauryl Sulfate (SLS) Applied as a Patch on Human Skin Physiology and Its Microbiota

Cliona varians-Derived Actinomycetes as Bioresources of Photoprotection-Related Bioactive End-Products

Natural alternatives from your garden for hair care: Revisiting the benefits of tropical herbs

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