UV Modulation of Subcutaneous Fat Metabolism

Kim, Sang Hyun; Kim, Yeon Kyung; Kim, Ji Eun; Kim, Sojeong; Kim, Minkyoung; Park, Chi‐Hyun; Chung, Jin Ho

doi:10.1038/jid.2011.106

Cited by 66 publications

(72 citation statements)

References 34 publications

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“…On sun-exposed areas such as the face, aging also causes a redistribution of fat between subcutaneous facial compartments, which is an important part of perceived facial aging Pessa 2007, 2008). These morphological changes are associated with physiological alteration of adipocyte metabolism and adipokine synthesis (Guo et al 2007;Kim et al 2011;Sepe et al 2011;Gulcelik et al 2013). Overall, the subcutaneous:visceral fat ratio in aged individuals is a stronger determinant of insulin resistance than amount of visceral fat alone (Gavi et al 2007;Frederiksen et al 2009).…”

Section: Aging Of Skin Adiposementioning

confidence: 99%

Natural and Sun-Induced Aging of Human Skin

Rittié

Fisher

2015

Cold Spring Harbor Perspectives in Medicine

394

382

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With worldwide expansion of the aging population, research on age-related pathologies is receiving growing interest. In this review, we discuss current knowledge regarding the decline of skin structure and function induced by the passage of time (chronological aging) and chronic exposure to solar UV irradiation ( photoaging). Nearly every aspect of skin biology is affected by aging. The self-renewing capability of the epidermis, which provides vital barrier function, is diminished with age. Vital thermoregulation function of eccrine sweat glands is also altered with age. The dermal collagenous extracellular matrix, which comprises the bulk of skin and confers strength and resiliency, undergoes gradual fragmentation, which deleteriously impacts skin mechanical properties and dermal cell functions. Aging also affects wound repair, pigmentation, innervation, immunity, vasculature, and subcutaneous fat homeostasis. Altogether, age-related alterations of skin lead to age-related skin fragility and diseases. S kin, like many other organs, undergoes deleterious changes with the passage of time and associated hormonal and dietary variations. Unlike most other organs, however, skin is also directly affected by exposure to the environment, especially UV irradiation from the sun. Chronic exposure to UV irradiation causes an aged phenotype ( photoaging) that is superimposed with aging caused by the passage of time (chronological aging). As a result, areas of the body that are frequently exposed to the sun such as the face, neck, forearms, or back of the hands acquire visible signs of aging more rapidly than other areas of the body.Skin serves two vital functions. First, skin serves as a barrier; it protects physical, chemical, and bacteriological intrusion in the body, and prevents dehydration by evaporative water loss. Second, skin allows thermoregulation through regulation of skin-hosted vasculature and eccrine sweat glands. In addition to these vital functions, skin mediates the sense of touch and plays a role in immune surveillance, hormone production, and social communication. Each of these functions is affected with aging. In general, alterations of skin structure and function appear earlier and are more pronounced in photoaged than in chronologically aged skin. Evidently, photoaging is a cumulative process and, as such, is more severe in older individuals.Passage of time and repeated exposure to harmful aspects of the environment alter both the epidermal and dermal compartments of the skin. Clinically, chronologically aged skin ap-

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Section: Aging Of Skin Adiposementioning

confidence: 99%

Natural and Sun-Induced Aging of Human Skin

Rittié

Fisher

2015

Cold Spring Harbor Perspectives in Medicine

394

382

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“…The elderly (mean age 72.7 years, age range 70-75 years) and young (mean age 35.3 year; age range 34-38 years) Koreans without current or prior skin disease provided both sun-protected buttock and photo-damaged extensor forearm skin samples. Another group of young volunteers (mean age 26.5 years, age range 21-33 years) provided buttock skin samples 10 . The buttock skin was irradiated with a F75/85 W/UV21 fluorescent lamp with an emission spectrum between 275 and 380 nm (peak at 310-315 nm).…”

Section: Methodsmentioning

confidence: 99%

“…Our prior study revealed that decreased lipid levels in photodamaged forearm SC fat tissues was not attributed to anatomical site differences, but to the chronic UV irradiation, because SC fat tissues from the forearm skin of young volunteers did not show significant decrease in the expression of these adipokines ( Supplementary Fig. 1), adipogenic transcription factors and lipogenic enzymes as well as lipid levels 10 , compared with those from the buttock skin of the same volunteers. Then we investigated expressions of these adipokines in acute UV-irradiated skin.…”

mentioning

confidence: 99%

“…1c). Previously, we demonstrated that acute exposure to UV dramatically decreased the mRNA expression of the transcription factors such as CCAAT/enhancer-binding protein (C/EBPα ), peroxisome proliferator-activated receptor (PPAR)γ , and sterol regulatory element binding protein (SREBP)1c in the SC fat tissues 10 . The fat mass is regulated by alterations in both number (adipogenesis) and volume (lipogenesis) of adipocytes 11 , and adipogenesis is primarily controlled by key transcription factors such as C/EBPα , PPARγ , and SREBP-1c [12][13][14] .…”

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confidence: 99%

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UV-induced inhibition of adipokine production in subcutaneous fat aggravates dermal matrix degradation in human skin

Lee

Kim

et al. 2016

Journal of Dermatological Science

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“…Thus, the production and secretion of growth factors is an essential function of ASCs, and these growth factors in turn exert diverse pharmacological effects, such as angiogenesis, wound healing, and hair growth promotion [5,[7][8][9][10]. External stimuli, such as hypoxia, induce response to UVB might be responsible for the reduction of adipogenesis in subcutaneous fat [14], the stimulatory effect of UVB light on ASCs isolated from this fatty tissue has not yet been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Ultraviolet B Preconditioning Enhances the Hair Growth-Promoting Effects of Adipose-Derived Stem Cells Via Generation of Reactive Oxygen Species

Jeong

Sung

Kim

et al. 2013

Stem Cells and Development

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Hypoxia induces the survival and regenerative potential of adipose-derived stem cells (ASCs), but there are tremendous needs to find alternative methods for ASC preconditioning. Therefore, this work investigated: (1) the ability of low-dose ultraviolet B (UVB) radiation to stimulate the survival, migration, and tube-forming activity of ASCs in vitro; (2) the ability of UVB preconditioning to enhance the hair growth-promoting capacity of ASCs in vivo; and (3) the mechanism of action for ASC stimulation by UVB. Although high-dose UVB decreased the proliferation of ASCs, low-dose (10 or 20 mJ/cm 2 ) treatment increased their survival, migration, and tube-forming activity. In addition, low-dose UVB upregulated the expression of ASC-derived growth factors, and a culture medium conditioned by UVB-irradiated ASCs increased the proliferation of dermal papilla and outer root sheet cells. Notably, injection of UVB-preconditioned ASCs into C 3 H/HeN mice significantly induced the telogen-to-anagen transition and increased new hair weight in vivo. UVB treatment significantly increased the generation of reactive oxygen species (ROS) in cultured ASCs, and inhibition of ROS generation by diphenyleneiodonium chloride (DPI) significantly attenuated UVB-induced ASC stimulation. Furthermore, NADPH oxidase 4 (Nox4) expression was induced in ASCs by UVB irradiation, and Nox4 silencing by small interfering RNA, like DPI, significantly reduced UVB-induced ROS generation. These results suggest that the primary involvement of ROS generation in UVB-mediated ASC stimulation occurs via the Nox4 enzyme. This is the first indication that a low dose of UVB radiation and/or the control of ROS generation could potentially be incorporated into a novel ASC preconditioning method for hair regeneration.

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UV Modulation of Subcutaneous Fat Metabolism

Cited by 66 publications

References 34 publications

Natural and Sun-Induced Aging of Human Skin

Natural and Sun-Induced Aging of Human Skin

UV-induced inhibition of adipokine production in subcutaneous fat aggravates dermal matrix degradation in human skin

Ultraviolet B Preconditioning Enhances the Hair Growth-Promoting Effects of Adipose-Derived Stem Cells Via Generation of Reactive Oxygen Species

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