UV-induced expression of GADD45 is mediated by an oxidant sensitive pathway in cultured human keratinocytes and in human skin in vivo.

Platelet-activating Factor Receptor Agonists Mediate Xeroderma Pigmentosum A Photosensitivity

“…Two separate mechanisms by which UVB irradiation can stimulate the non-enzymatic production of PAF-R agonists have been demonstrated. First, UVB irradiation can generate the delayed production of ROS through a process involving NADPH and the epidermal growth factor receptor (40,62,63). A second mechanism for Ox-GPC generation appears to be the direct absorption of UVB irradiation by lipids and is immediate (28,29,40).…”

Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects

“…UVR mediated changes to phospholipids is therefore thought to occur as a result of photo-oxidation reactions 80 . Recent studies by photobiologists indicate that UVB generates ROS through a series of sequential steps involving: EGFR activation, ROS generation by cytosolic NADPH oxidase, ras/ERK & p38MAPK activation, p53 activation, and finally apoptotic signaling leading to mitochondrial ROS generation [81][82][83][84][85][86][87][88] . Thus, UVBmediated ROS are likely involved in the generation of ox-GPCs.…”

Loss of expression of the growth inhibitory gene GADD45γ, in human pituitary adenomas, is associated with CpG island methylation

“…Indeed, it cannot be discounted that their inappropriate expression might reflect an appropriate response to upstream or downstream factors that are themselves subject to dysregulation. GADD45g, also known as cytokine response gene 6 (CR6), is involved in growth-suppressive and apoptotic pathways (Takekawa and Saito, 1998;Wan et al, 2000). The full-length cDNA sequences of murine (Zhang et al, 1999a) and human (Takekawa and Saito, 1998) GADD45g have been determined and the human sequence is located on the long arm of chromosome 9 (9q22.2).…”