2010
DOI: 10.1021/ja102595j
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UV and Near-IR Triggered Release from Polymeric Nanoparticles

Abstract: A new light-sensitive polymer containing multiple light-sensitive triggering groups along the backbone and incorporating a quinone-methide self-immolative moiety was developed and formulated into nanoparticles encapsulating a model dye Nile Red. Triggered burst-release of the payload upon irradiation and subsequent degradation of the nanoparticles was observed. This system is designed to be versatile where the triggering group can be sensitive to a number of wavelengths.

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Cited by 353 publications
(339 citation statements)
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“…126 Drug release from nanoparticles can be triggered using ultrasound, light, and other physical and chemical environmental changes. 133,134 Recently, a new light-sensitive polymer based on the quinone-methide system was developed, which degrades when exposed to irradiation at 350 nm and 750 nm. 133 Nanoparticles made with this polymer released an encapsulated drug (in this case, the Nile Red dye) when exposed to the specific light wavelength(s).…”
Section: Controlled Releasementioning
confidence: 99%
“…126 Drug release from nanoparticles can be triggered using ultrasound, light, and other physical and chemical environmental changes. 133,134 Recently, a new light-sensitive polymer based on the quinone-methide system was developed, which degrades when exposed to irradiation at 350 nm and 750 nm. 133 Nanoparticles made with this polymer released an encapsulated drug (in this case, the Nile Red dye) when exposed to the specific light wavelength(s).…”
Section: Controlled Releasementioning
confidence: 99%
“…The examined polymer combined multiple light-sensitive triggering groups along the backbone with quinine-methide self-immolative moieties. 304 A drawback however, is the complex preparation method including several extensive synthetic steps.…”
Section: Photo-resist Nanoparticles: Light-induced Degradation Of Hydmentioning
confidence: 99%
“…88,95 Therefore, it is of high importance to ensure a successful retention of the functional molecule in the carrier system until the desired site or time point for its triggered release is reached. This can be achieved by several approaches including, among others, the embedding of hydrophobic drugs into either non-swollen hydrophobic polymeric nanoparticles and their stimuli-induced swelling 109,304 or into hydrophobic domains in hydrophilic microgels. 308 The covalent attachment of a drug to a hydrophilic polymeric carrier system via a cleavable molecule and the triggered degradation of the linker is another promising method.…”
Section: Towards Stimuli-responsive Core/shell Nanoparticles Containimentioning
confidence: 99%
“…The use of nanocarriers that can be remotely disassembled to release RA with spatial and temporal resolution are of high therapeutic value [15,16]. Even if LR-NP distribute to other tissues, RA will be released only upon light stimulation, bypassing possible side effects [17].…”
Section: Introductionmentioning
confidence: 99%