UV-A1 Phototherapy for Sclerotic Skin Diseases

Ultraviolet A1 Phototherapy for Fibrosing Conditions

“…Because UV-A1 penetrates into the subcutis only, the aforementioned conditions rather require systemic immunosuppressive treatment such as methotrexate (65). Evidence indicates that UV-A1 phototherapy acts through diminishment of cutaneous T cell infiltrates, down-regulation of pro-inflammatory cytokines, changes in endothelial cell function, and induction of programmed cell death.…”

“…It was shown in vitro that UV-A1 irradiation of cultured fibroblasts obtained from LoS patients resulted in increased collagenase gene and protein expression. After UV-A1 irradiation, it was also observed a fast production of interleukin 1 (IL-1) stimulating the release of IL-6 which mediates an upregulation of collagenase synthesis by fibroblasts (14, 65–71). …”

Morphea – selected local treatment methods and their effectiveness

“…Depending on the wavelength, the ultraviolet radiation is characterised by a varied penetration into the skin. UVB radiation reaches the papillary dermis, whereas UVA can penetrate skin even to the subcutis [ 33 ]. UVC radiation is not used for treatment purposes because the radiation of such wavelength has no ability to reach the dermis [ 32 ].…”

“…UVC radiation is not used for treatment purposes because the radiation of such wavelength has no ability to reach the dermis [ 32 ]. It is assumed that the beneficial effect of ultraviolet radiation in treating patients suffering from sclerosing skin diseases is connected with the reduction of collagen level subtype I and III within the lesions, which is a result of diminished synthesis and increased degradation of this protein [ 33 ].…”