Uttarakhand Medicinal Plants Database (UMPDB): A Platform for Exploring Genomic, Chemical, and Traditional Knowledge

Abstract

Abstract:Medicinal plants are the main natural pools for the primary health care system, ethno-medicine, as well as traditional Indian system of several medicines. Uttarakhand also known as 'Herbal State', is a rich source of medicinal plants and traditional medicinal knowledge. A great deal of information about medicinal plants of Uttarakhand is scattered in different forms. Although many medicinal plant databases are available, currently there is no cohesive manually curated database of medicinal plants widely distributed in Uttarakhand state. A comprehensive database has been developed, known as the Uttarakhand Medicinal Plants Database (UMPDB). UMPDB provides extensive information on botanical name, common name, taxonomy, genomic taxonomy id, habit, habitat, location in Uttarakhand, part use, medicinal use, genomic information (including number of nucleotides, proteins, ESTs), chemical information, and scientific literature. Annotated medicinal plants integrated in the current version of the database were collected from the existing books, databases, and available literature. The current version of UMPDB contains the 1127 records of medicinal plants which belong to 153 plant families distributed across 13 districts of Uttarakhand. The primary goal of developing this database is to provide traditional, genomic, and chemical descriptions of the medicinal plants exclusively found in various regions of Uttarakhand. We anticipate that embedded information in the database would help users to readily obtain desired information.

Identification of natural inhibitors against Mpro of SARS-CoV-2 by molecular docking, molecular dynamics simulation, and MM/PBSA methods

“…Plant-derived natural products play a significant role in discovering and producing drug candidates by being the lead molecule (Joseph et al, 2017 ). Ancient Indian scriptures, including Rig-Veda, Atherveda, and Charka Sanhita, demonstrated great benefits of plants for treating various human ailments (Kumar et al, 2018 ). Plants are an excellent natural source of high-value alkaloids, flavonoids, lignans, polyketides, alkanes, alkenes, alkynes, aromatics, peptides, terpenoid, phenols, coumarins, and steroids.…”

“…Plants are an excellent natural source of high-value alkaloids, flavonoids, lignans, polyketides, alkanes, alkenes, alkynes, aromatics, peptides, terpenoid, phenols, coumarins, and steroids. In the current time of drug discovery, plants' enormous medicinal properties allow the researchers to exclusively use them for the discovery of drug-like natural molecules (Jee et al, 2018 ; Kumar et al, 2018 ; Panchangam et al, 2016 ).…”

Natural xanthone compounds as promising drug candidates against COVID-19 - An integrated molecular docking and dynamics simulation study

“…For the MD simulation analysis, we followed the methods employed by Gajula et al (2016), Jee et al (2018, and Kumar et al (2018Kumar et al ( , 2020. Using the PRODRG server, topology files of ligand molecules were prepared (Schüttelkopf and van Aalten, 2004).…”

“…The development of medicine is the need of the hour. Xanthones are polyphenolic secondary metabolites with antiviral, anti-obesity, anti-HIV, antidiabetic, and anticancer activities (Anantachoke et al, 2012;Kumar et al, 2018).…”

Policy in the Peaks: Cybercartography and Traditional Ecological Practices to Diversify Pasture Policy-Making in Naryn Province, Kyrgyzstan

“…The Atlas served as a platform to create a dialogue between pasture users and experts, where both sides could independently post comments on the Atlas's features. While systems for online identification of ailments and medicinal plants are well established elsewhere(Kumar et al 2018), this cybercartographic implementation allows local participants equal footing to frame the research questions and pose them to experts. Shifting the research-forming process to pasture users in turn encouraged an attitude change towards citizen engagement in pasture management; 55% of participants indicated an endline change of being more committed and involved in decision-making processes, compared to 18% at baseline.…”