Utilizing protein nanofibrils as a scaffold for enhancing nutritional value in toned milk

Senthilkumar, Praveetha; Natarajan, Arunadevi; Salmen, Saleh H.; Alharbi, Sulaiman Ali; Shavrov, Vladimir; Lega, Petr; Subramani, Ramesh; Pushparaj, Charumathi

doi:10.1016/j.envres.2023.117420

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…After the impurities were removed, the solution was heated at 80°C for 10 h using a thermomixer (Eppendorf thermomixer C-F 1.5) with constant shaking at 1000 rpm. The resulting solution was kept refrigerated at 4°C and used both as a control and for further preparations (Senthilkumar, Chandran, et al, 2022;Senthilkumar et al, 2023).…”

Section: Preparation Of β-Lg Nanofibrilsmentioning

confidence: 99%

Improving therapeutic potential in breast cancer via histone deacetylase inhibitor loaded nanofibrils

Senthilkumar,

Gogoi,

Dhan

et al. 2024

Drug Development Research

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Epigenetic modifications play a significant role in cancer progression, making them potential targets for therapy. Histone deacetylase inhibitors have shown promise in inhibiting cancer cell growth, including in breast cancer (BC). In this research, we examined the potential of using suberoyl anilide hydroxamic acid (SAHA)‐loaded β‐lg nanofibrils as a drug delivery system for triple‐negative BC cell lines. We assessed their impact on cell cycle progression, apoptosis, levels of reactive oxygen species, and mitochondrial membrane potential in cancer cells. The combination of SAHA and β‐lg nanofibrils demonstrated enhanced efficacy in inhibiting cell growth, inducing cell cycle arrest, and promoting apoptosis (43.78%) compared to SAHA alone (40.09%). Moreover, it effectively targeted cancer cells without promoting drug resistance while using a low concentration of the nanofibrils. These findings underscore the promising potential of nanofibril‐based drug delivery systems for BC treatment.

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Section: Preparation Of β-Lg Nanofibrilsmentioning

confidence: 99%

Improving therapeutic potential in breast cancer via histone deacetylase inhibitor loaded nanofibrils

Senthilkumar,

Gogoi,

Dhan

et al. 2024

Drug Development Research

Self Cite

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Almond gum‐chitosan nanocomposite as edible formulation for advancing postharvest longevity of fruits and vegetables

Suresh,

SenthilKumar,

Pushparaj

et al. 2024

Polymers for Advanced Techs

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Postharvest produces including fruits and vegetables are perishable and require preservation for prolonged shelf life. Edible coatings are emerging as a safe and value‐added alternative for traditional preservation methods such as refrigeration and chemical treatments. In this article, we have developed almond gum/chitosan (AC)‐based edible coating/formulation and investigated the effectiveness of coating on improving the shelf life of tomatoes and blueberries. The coated tomatoes and blueberries, after a shelf life of 25 and 20 days, respectively exhibited a significant improvement in weight loss (5%–20%), reduced acidity (1–3 folds), and kept the ascorbic acid content lower when compared to the uncoated tomatoes and blueberries. Both the coated tomatoes and blueberries did not exhibit spoilage indicating antimicrobial activity of the coating. Direct testing of the coating formulations exhibited significant anti‐microbial activity against Staphyococcus aureus and Pseudomonas aeroginosa. The polymer films, prepared using the coating formulation, exhibited low moisture content (34.8 ± 2.02% and 41.5 ± 1.34%), low solubility (42.56 ± 2.3% and 31.31 ± 3.1%), low tensile strength (0.34 ± 0.05 N m−2 and 0.75 ± 0.07 N m−2) and high elongation (63.2 ± 4.12% and 71.5 ± 3.8%). These measured film properties confirm that the polymer film has good flexibility and is suitable for edible packaging. Overall, the newly developed AC edible coating exhibits significant potential for a wide range of applications within the food processing industry, offering a viable substitute for conventional wax and lipid‐based coatings.

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Utilizing protein nanofibrils as a scaffold for enhancing nutritional value in toned milk

Cited by 2 publications

References 38 publications

Improving therapeutic potential in breast cancer via histone deacetylase inhibitor loaded nanofibrils

Improving therapeutic potential in breast cancer via histone deacetylase inhibitor loaded nanofibrils

Almond gum‐chitosan nanocomposite as edible formulation for advancing postharvest longevity of fruits and vegetables

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