Heavy metal (HM) contents in periwinkle and tilapia from Warri coastal water were carried out during dry and wet seasons of 2008 and 2009. Samples were collected from ten sampling locations. HM was determined using atomic absorption spectrophotometer-varian model spectral AA 220. The range of HM concentrations viz Pb, Ni, Fe, Cu, Zn, Cd, Mn and Cr in periwinkle were found to be 0.68-10.34mg/kg, 1.21-8.01mg/kg, 198.73-457.11mg/kg, 0.002-4.60mg/kg, 1.02-5.06mg/kg, 0.002-0.54mg/kg, 10.00-72.27mg/kg and 205.09-1,453mg/kg respectively. In tilapia, the concentrations ranged from 0.73-3.25mg/kg, 0.72-482.00mg/kg, 0.001-1.93mg/kg, 3.02-459.00mg/kg, 0.83-3.75mg/kg, 0.65-1.45mg/kg,1.25-5.01mg/kg and 344.02-969.00mg/kg respectively. The results show that Fe, Mn and Cr in periwinkle and only Cr in tilapia were higher than other metals determined. The concentrations of heavy metals during wet season were slightly higher than dry season except in few occasions. Also, the heavy metal concentrations of the year 2009 were generally higher than the year 2008 indicating more of these metals were discharged or introduced into water/sediment environment than the previous year which enhanced bio-accumulation in these fauna. These generally suggest an evidence of these fauna to bio-concentrate these metals.