Utilization of the Organ Care System Lung for the assessment of lungs from a donor after cardiac death (DCD) before bilateral transplantation

Mohite, Prashant N.; Sabashnikov, Anton; Sáez, Diana García; Pates, Bradley; Zeriouh, Mohamed; Robertis, Fabio De; Simon, A.

doi:10.1177/0267659114557186

Cited by 15 publications

(11 citation statements)

References 12 publications

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“…A lactate level below 5 mmol/l at the end of the perfusion period is considered to be the key criterion for organ transplantation. Gas exchange is a fundamental indicator in lung EVNP, and in the liver the production of bile is the important parameter. Reliable and rapid techniques to assess the quality and suitability of a kidney are also essential to ensure the safe expansion of the marginal kidney donor programme.…”

Section: Discussionmentioning

confidence: 99%

Ex vivo normothermic perfusion for quality assessment of marginal donor kidney transplants

Hosgood

Barlow

Hunter

et al. 2015

British Journal of Surgery

119

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Section: Discussionmentioning

confidence: 99%

Ex vivo normothermic perfusion for quality assessment of marginal donor kidney transplants

Hosgood

Barlow

Hunter

et al. 2015

British Journal of Surgery

119

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“…Recently, Mohite et al published a successful case report using the OCS TM Lung for the preservation and assessment of a DCD donor lungs who died 6 min after WLST. Donor criteria were not documented (56).…”

Section: Clinical Evlp Using the Ocs Tm Methodsmentioning

confidence: 99%

Ex vivo lung perfusion

Reeb

Cypel

2016

Clinical Transplantation

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Lung transplantation is an established life-saving therapy for patients with end-stage lung disease. Unfortunately, greater success in lung transplantation is hindered by a shortage of lung donors and the relatively poor early-, mid-, and long-term outcomes associated with severe primary graft dysfunction. Ex vivo lung perfusion has emerged as a modern preservation technique that allows for a more accurate lung assessment and improvement in lung quality. This review outlines the: (i) rationale behind the method; (ii) techniques and protocols; (iii) Toronto ex vivo lung perfusion method; (iv) devices available; and (v) clinical experience worldwide. We also highlight the potential of ex vivo lung perfusion in leading a new era of lung preservation.

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“…More recently, an integrated and transportable machine perfusion system, the Organ Care Support (OCS) Lung (Transmedics, Andover, MA, USA), has been used for lung assessment and reconditioning. The Harefield Hospital group presented the first experience with OCS in the DCD setting: they noted that this system allows for continuous ventilation, recruitment manoeuvres and further bronchoscopic evaluations (37).…”

Section: Machine Perfusion Technique In Dcdmentioning

confidence: 99%

Lung donation after circulatory death

Musso¹,

Righi²,

Damarco³

et al. 2023

Curr Chall Thorac Surg

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Donation after circulatory death (DCD) defines organs procurement after death determined using circulatory criteria, as opposed to a declaration based on neurological criteria. Nowadays, DCD donors represent a valuable resource to contrast lung donor shortage and waiting list mortality, while also avoiding the potential lung damages generated by brain death. On the other hand, lungs from DCD donors are exposed to a variable warm ischemia time and related potential detrimental effects. The extensive experimental investigation proved the feasibility of this practice, and the subsequent clinical experiences around the world showed good outcomes. In this paper, we review the pre-clinical and clinical experiences in the DCD field, focusing on ischemia time and the biological peculiarities of the lung tissue in animal models.We illustrate the clinical paths of the DCD donor categories as described in the Maastricht classification, and the different preservation techniques and procurement protocols, with particular regard to the ethical and legal differences around the world. We analyse the characteristics of both the controlled and uncontrolled setting, highlighting the advantages and disadvantages of each donation setting. We then proceed to review the clinical outcomes as well as the complications after lung transplantation from DCD donors as reported in literature. Lastly, we outline the role of machine perfusion for the function assessment and reconditioning of grafts procured in this scenario.

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Utilization of the Organ Care System Lung for the assessment of lungs from a donor after cardiac death (DCD) before bilateral transplantation

Cited by 15 publications

References 12 publications

Ex vivo normothermic perfusion for quality assessment of marginal donor kidney transplants

Ex vivo normothermic perfusion for quality assessment of marginal donor kidney transplants

Ex vivo lung perfusion

Lung donation after circulatory death

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