Utilization of Stearic acid Extracted from Olive Pomace for Production of Triazoles, Thiadiazoles and Thiadiazines Derivatives of Potential Biological Activities

Separation of palmitic acid from over used oil for production of heterogeneous organic derivatives of potential biological activities

“…The new prepared compounds are expected to be biologically beneficial in combating microorganisms, moreover these compounds are expected to have several advantages over the parent heterocyclic one, where they may easily penetrate the lipoprotein cell membrane, they may be stored in liver and skin as a lipid component that can be used whenever they needed, also the toxicity and side effects of this new compounds may be reduced by the presence of the long chain fatty acid residue which circulate the hetero nucleus [17].…”

“…Palmitic acid was extracted from Over used oil according to the method described by Hanaa Soliman et al [17]. Where The over used oil (200 g) was hydrolyzed using distilled water (500 ml) and high pressure reactor at 250˚C and 2 MPa [22], then, the reaction left to cool to room temperature, where the reaction mixture was separated into two layers.…”

“…sulfuric acid (5 ml) was added to a mixture of hexadecanoic acid (6.41 g, 25 mmol) and absolute methanol (40 ml) in dry benzene (100 ml), and heated under reflux for 6 hr then it was cooled to room temperature, washed with water till complete removal of sulfuric acid. Then the ester layer was separated from benzene by extraction with diethyl ether, and the solvent was evaporated under reduced pressure [17] Preparation of Hexadecanyl hydrazide (2) To a mixture of methyl hexadecanoate (1) (2.70 g, 10 mmol) in dry benzene (30 ml) hydrazine hydrate (0.49 ml, 10 mmol) was added. The mixture was refluxed for 6 hr, then it was allowed to cool, and poured into acidified icecold water with continuous stirring.…”

“…Thus the new synthesized compounds may possess various preferences over the origin heterocyclic one, where they could permeated through the lipoprotein cell membrane, on the other hand, it's possible to be stored in liver and skin as a lipid component in order to be used whenever they needed, more over the long chain fatty acid residue that surround the hetero nucleus may lower the toxicity and side effects of this new compounds [17].…”

“…Appending of these heterocyclic compounds to stearic acid and oleic acid (those were obtained from pomace olive), had been previously prepared, and had proved a good biological activities [17,18]. This work is made as to explore whether the fatty acid chain length affect the biological activity of the heterocyclic compounds or not.…”