Utilization of rapid prototyping technology for the fabrication of an orthopedic shoe inserts for foot pain reprieve using thermo-softening viscoelastic polymers: A novel experimental approach

Sharma, Shubham; Singh, Jujhar; Kumar, Harish; Sharma, Abhinav; Aggarwal, Vivek; Gill, Amoljit Singh; Jayarambabu, N.; Kailasa, Saraswathi; Rao, K. Venkateswara

doi:10.1177/0020294019887194

Cited by 36 publications

(29 citation statements)

References 28 publications

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“…Utilization with biocompatible polymers minimizes a drug’s adverse effects and negative consequences. Biopolymers, including biodegradable biopolymers, do not have a persistent inflammatory influence, and are characterized by high porosity and permeability, and outstanding therapeutic properties [ 369 , 370 , 371 ].…”

Section: Resultsmentioning

confidence: 99%

Critical Review of Biodegradable and Bioactive Polymer Composites for Bone Tissue Engineering and Drug Delivery Applications

et al. 2021

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In the determination of the bioavailability of drugs administered orally, the drugs’ solubility and permeability play a crucial role. For absorption of drug molecules and production of a pharmacological response, solubility is an important parameter that defines the concentration of the drug in systemic circulation. It is a challenging task to improve the oral bioavailability of drugs that have poor water solubility. Most drug molecules are either poorly soluble or insoluble in aqueous environments. Polymer nanocomposites are combinations of two or more different materials that possess unique characteristics and are fused together with sufficient energy in such a manner that the resultant material will have the best properties of both materials. These polymeric materials (biodegradable and other naturally bioactive polymers) are comprised of nanosized particles in a composition of other materials. A systematic search was carried out on Web of Science and SCOPUS using different keywords, and 485 records were found. After the screening and eligibility process, 88 journal articles were found to be eligible, and hence selected to be reviewed and analyzed. Biocompatible and biodegradable materials have emerged in the manufacture of therapeutic and pharmacologic devices, such as impermanent implantation and 3D scaffolds for tissue regeneration and biomedical applications. Substantial effort has been made in the usage of bio-based polymers for potential pharmacologic and biomedical purposes, including targeted deliveries and drug carriers for regulated drug release. These implementations necessitate unique physicochemical and pharmacokinetic, microbiological, metabolic, and degradation characteristics of the materials in order to provide prolific therapeutic treatments. As a result, a broadly diverse spectrum of natural or artificially synthesized polymers capable of enzymatic hydrolysis, hydrolyzing, or enzyme decomposition are being explored for biomedical purposes. This summary examines the contemporary status of biodegradable naturally and synthetically derived polymers for biomedical fields, such as tissue engineering, regenerative medicine, bioengineering, targeted drug discovery and delivery, implantation, and wound repair and healing. This review presents an insight into a number of the commonly used tissue engineering applications, including drug delivery carrier systems, demonstrated in the recent findings. Due to the inherent remarkable properties of biodegradable and bioactive polymers, such as their antimicrobial, antitumor, anti-inflammatory, and anticancer activities, certain materials have gained significant interest in recent years. These systems are also actively being researched to improve therapeutic activity and mitigate adverse consequences. In this article, we also present the main drug delivery systems reported in the literature and the main methods available to impregnate the polymeric scaffolds with drugs, their properties, and their respective benefits for tissue engineering.

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Section: Resultsmentioning

confidence: 99%

Critical Review of Biodegradable and Bioactive Polymer Composites for Bone Tissue Engineering and Drug Delivery Applications

et al. 2021

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“…Interestingly, at higher natural fiber loading (15 wt% jute and grewia), the improvement in the erosive wear was not significant as obtained in the study. Apparently, the erosive wear examination revealed that main wear mechanism responsible for material removal is groove formation and micro-ploughing [ 63 , 64 , 65 ]. A close examination also discloses brittle fractures at some parts, which shows that a small amount of impact forces was also acting on the samples.…”

Section: Resultsmentioning

confidence: 99%

Comparative Analysis of Erosive Wear Behaviour of Epoxy, Polyester and Vinyl Esters Based Thermosetting Polymer Composites for Human Prosthetic Applications Using Taguchi Design

Khare¹,

Dahiya²,

Gangil

et al. 2021

Polymers

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In polymer composites, synthetic fibers are primarily used as a chief reinforcing material, with a wide range of applications, and are therefore essential to study. In the present work, we carried out the erosive wear of natural and synthetic fiber-based polymer composites. Glass fiber with jute and Grewia optiva fiber was reinforced in three different polymer resins: epoxy, vinyl ester and polyester. The hand lay-up method was used for the fabrication of composites. L16 orthogonal array of Taguchi method used to identify the most significant parameters (impact velocity, fiber content, and impingement angle) in the analysis of erosive wear. ANOVA analysis revealed that the most influential parameter was in the erosive wear analysis was impact velocity followed by fiber content and impingement angle. It was also observed that polyester-based composites exhibited the highest erosive wear followed by vinyl ester-based composites, and epoxy-based composites showed the lowest erosive wear. From the present study, it may be attributed that the low hardness of the polyester resulting in low resistance against the impact of erodent particles. The SEM analysis furthermore illustrates the mechanism took place during the wear examination of all three types of composites at highest fiber loading. A thorough assessment uncovers brittle fractures in certain regions, implying that a marginal amount of impact forces was also acting on the fabricated samples. The developed fiber-reinforced polymer sandwich composite materials possess excellent biocompatibility, desirable promising properties for prosthetic, orthopaedic, and bone-fracture implant uses.

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“…Conducting polymers also find applications in tissue engineering due to their stimulusresponsive property. The composites of these polymers act as substrates that promote cell growth, adhesion, and proliferation at the polymer-tissue interface [130,131,[145][146][147][148][149][150][151][152][153][154][155][156][157][158].…”

Section: Tissue Engineeringmentioning

confidence: 99%

“…The graphene nanohybrid of these polymers is used as an electrode in synthesis of capacitors. These nanohybrid materials increase stability, flexibility, and capacity of capacitors [149][150][151][152][153][154][155][156][157][158][159][160][161]. The different properties of polymers like thermal stability, mechanical properties, conductivity, corrosion protection properties on steel and aluminium can be escalated to a firm extent by doping.…”

Section: Diabetic Monitoringmentioning

confidence: 99%

Recent Trends and Developments in Conducting Polymer Nanocomposites for Multifunctional Applications

et al. 2021

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Electrically-conducting polymers (CPs) were first developed as a revolutionary class of organic compounds that possess optical and electrical properties comparable to that of metals as well as inorganic semiconductors and display the commendable properties correlated with traditional polymers, like the ease of manufacture along with resilience in processing. Polymer nanocomposites are designed and manufactured to ensure excellent promising properties for anti-static (electrically conducting), anti-corrosion, actuators, sensors, shape memory alloys, biomedical, flexible electronics, solar cells, fuel cells, supercapacitors, LEDs, and adhesive applications with desired-appealing and cost-effective, functional surface coatings. The distinctive properties of nanocomposite materials involve significantly improved mechanical characteristics, barrier-properties, weight-reduction, and increased, long-lasting performance in terms of heat, wear, and scratch-resistant. Constraint in availability of power due to continuous depletion in the reservoirs of fossil fuels has affected the performance and functioning of electronic and energy storage appliances. For such reasons, efforts to modify the performance of such appliances are under way through blending design engineering with organic electronics. Unlike conventional inorganic semiconductors, organic electronic materials are developed from conducting polymers (CPs), dyes and charge transfer complexes. However, the conductive polymers are perhaps more bio-compatible rather than conventional metals or semi-conductive materials. Such characteristics make it more fascinating for bio-engineering investigators to conduct research on polymers possessing antistatic properties for various applications. An extensive overview of different techniques of synthesis and the applications of polymer bio-nanocomposites in various fields of sensors, actuators, shape memory polymers, flexible electronics, optical limiting, electrical properties (batteries, solar cells, fuel cells, supercapacitors, LEDs), corrosion-protection and biomedical application are well-summarized from the findings all across the world in more than 150 references, exclusively from the past four years. This paper also presents recent advancements in composites of rare-earth oxides based on conducting polymer composites. Across a variety of biological and medical applications, the fact that numerous tissues were receptive to electric fields and stimuli made CPs more enticing.

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Utilization of rapid prototyping technology for the fabrication of an orthopedic shoe inserts for foot pain reprieve using thermo-softening viscoelastic polymers: A novel experimental approach

Cited by 36 publications

References 28 publications

Critical Review of Biodegradable and Bioactive Polymer Composites for Bone Tissue Engineering and Drug Delivery Applications

Critical Review of Biodegradable and Bioactive Polymer Composites for Bone Tissue Engineering and Drug Delivery Applications

Comparative Analysis of Erosive Wear Behaviour of Epoxy, Polyester and Vinyl Esters Based Thermosetting Polymer Composites for Human Prosthetic Applications Using Taguchi Design

Recent Trends and Developments in Conducting Polymer Nanocomposites for Multifunctional Applications

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