Utilization of Olive Pomace in Green Synthesis of Selenium Nanoparticles: Physico-Chemical Characterization, Bioaccessibility and Biocompatibility

Abstract

Olive pomace extract (OPE) was investigated as a potential surface modifier for the development of the green synthesis process of selenium nanoparticles (SeNPs). In order to evaluate them as potential nutraceuticals, the obtained nanosystems were characterized in terms of size distribution, shape, zeta potential, stability in different media, gastrointestinal bioaccessibility and biocompatibility. Systems with a unimodal size distribution of spherical particles were obtained, with average diameters ranging from 53.3 nm to 181.7 nm, depending on the type of coating agent used and the presence of OPE in the reaction mixture. The nanosystems were significantly affected by the gastrointestinal conditions. Bioaccessibility ranged from 33.57% to 56.93% and it was significantly increased by functionalization of with OPE. Biocompatibility was investigated in the HepG2 and Caco2 cell models, proving that they had significantly lower toxicity in comparison to sodium selenite. Significant differences were observed in cellular responses depending on the type of cells used, indicating differences in the mechanisms of toxicity induced by SeNPs. The obtained results provide new insight into the possibilities for the utilization of valuable food-waste extracts in the sustainable development of nanonutraceuticals.

Selenium Nanoparticles as Potential Drug-Delivery Systems for the Treatment of Parkinson’s Disease

“…The fluorescence spectral properties of l -DOPA and dopamine were based on the contribution from phenylalanine, while tryptophan (Trp) and tyrosine (Tyr) predominantly contributed to the intrinsic fluorescence of hTF. , When excited at 280 nm, l -DOPA and dopamine exhibited fluorescence emissions at 317 nm and hTF displayed emission at 350 nm. Increasing concentrations of PVP-SeNPs and Tween-SeNPs reduced the intrinsic fluorescence of the fluorophores at each tested temperature (288, 298, or 308 K).…”

“…PVP-functionalized SeNPs were synthesized using a previously published procedure with some adjustments, as illustrated in Scheme a. The first step was the addition of a solution containing 10 mL of 1 wt % PVP to 77.9 mL of UPW followed by stirring at 500 rpm for 15 min.…”

Does the Type Matter? Verification of Different Tea Types’ Potential in the Synthesis of SeNPs

“…The zeta potential of a nanoparticle is the measure of its surface charge density. It affects the stability of the nanoparticles, but also determines the way in which they interact with biological systems [ 49 ].…”

Bioaccessibility and bioactive potential of different phytochemical classes from nutraceuticals and functional foods

“…Overall, mineral-enriched probiotics present good potential for the fortification of functional foods (133). Moreover, functionalization of Se nanoparticles with plant material can rise the bioaccessibility and compatibility of this mineral (134).…”