Utilization of Nanomaterials in Target Oriented Drug Delivery Vehicles

Mandal, Tapan Kumar; Patait, V.

doi:10.3329/jsr.v13i1.47690

Cited by 3 publications

(2 citation statements)

References 46 publications

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“…Iron oxide nanoparticles are considered emergent in the scientific community due to their potential biomedical applications arising from their biocompatibility and non-toxicity [1]. The superparamagnetic nature of iron oxide nanoparticles allows them to be potentially used in magnetic separation, drug delivery, magnetic resonance imaging (MRI), and hyperthermia of cancer cells [2][3][4][5]. However, preparing high-quality and properly engineered magnetic iron oxide nanoparticles is challenging for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Glucose Functionalized Magnetic Iron Oxide Nanoparticles for Protein Detection and Separation

Basiruddin

2024

J. Sci. Res.

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Iron oxide magnetic nanoparticles (MNP) are considered to be emergent nanoparticles for magnetic separation and MRI imaging probes. Here, glucose-functionalized iron oxide (γ-Fe2O3) magnetic nanoparticles have been prepared for specific protein detection and separation. First, hydrophobic iron oxide (γ-Fe2O3) was synthesized by standard organometallic approaches, and the same has been converted to soluble, colloidally stable, hydrophilic primary amine (-NH2)-PEG terminated iron oxide (γ-Fe2O3) nanoparticles using reverse micelle based robust polyacrylate coating chemistry. Then, glucose was covalently linked to this amine (-NH2)-PEG terminated iron oxide (γ-Fe2O3) nanoparticles by using glutaraldehyde-based coupling chemistry. Finally, glucose-functionalized iron oxide (γ-Fe2O3) nanoparticles have been used for specific detection and separation of a glycoprotein, Concanavalin-A.

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Section: Introductionmentioning

confidence: 99%

Glucose Functionalized Magnetic Iron Oxide Nanoparticles for Protein Detection and Separation

Basiruddin

2024

J. Sci. Res.

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“…These nanocarriers with therapeutic loads can have minimum adverse effects. Nanoparticle materials provide potential advantages due to their unique size, physiological nature, thermal, optical, electrical, and magnetic properties, different from traditionally used materials [1][2][3][4]. A balanced perception of the relation between inorganic nanomaterials and the biological system has led to the emergence of better solutions for individualized medicine.…”

Section: Introductionmentioning

confidence: 99%

Polymeric Fe<sub>3</sub>O<sub>4</sub> Conjugates with Bioactive Plant Molecules: Platforms for Antimicrobial Therapy

Fernandes

Vaz

Gurav³

et al. 2021

J. Sci. Res.

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The emerging nano biosystems are competent in diagnosis, drug delivery, and monitoring of therapeutic response. Both imaging and therapeutic functions can be achieved by using nanoplatforms. These nanoplatforms promise to revolutionize the medical management of many personalized illnesses. The well-developed surface chemistry of iron oxide (Fe3O4) makes it easy to charge them with pharmaceutics, promoting them as nanoplatforms for building up nanoparticle-based drug delivery systems. The strategy to design multifunctional Fe3O4 conjugates with bioactive molecules of plant origin to show enhanced activity is reported here. The conjugation reveals the magnetic Fe3O4 core nanoparticle surface readily link to hydroxyl sites of the Dextrin molecule, which further conjugate to conjugated with Curcumin and D-Limonene, which are powerful anti-cancer, anti-inflammatory, and antioxidant agents. The structural, morphological, optical, and magnetic properties were analyzed by X-ray diffraction, FT-Infrared, HR-Tunneling Electron Microscopy, and Vibrating Sample Magnetometer techniques. The potential drug loading was measured as Drug Entrapment Efficiency using UV-Vis spectroscopy. The antibacterial property was tested on the bacterium S. aureus and E. coli. Fe3O4-Dextrin nanoconjugates proved to be efficient for loading and stabilizing Curcumin and Limonene. Thus, multifunctional Fe3O4 conjugates are explored as exciting nano-drug carriers for targeted drug delivery.

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Antimicrobial and antioxidant therapy with bioactive plant molecules on Fe3O4 phytohybrid nanoplatforms

2021

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Background Nanobiomedicines have gained increasing attention for their potential to improve efficacy and are emerging as a promising therapeutic paradigm. Magnetic nanoconjugates loaded with bioactive drugs have the advantage of sustained circulation in the bloodstream and significantly reduced toxicity of therapeutic agents in a precise manner. The well-developed surface chemistry of Fe3O4 has led to the development better tools, promoting them as nanoplatforms with potential technological applications in biomedical sciences. Results Fe3O4 phytohybrids with Laxmitaru extract as the primary coating and loaded with Eugenol and Ylang-Ylang essential oils were successfully synthesized. The X-ray diffraction technique has revealed the high purity nanoparticle materials, as no additional impurity peaks were observed. Fourier transform infra-red spectra have confirmed the presence of a primary coating of Laxmitaru extract and a secondary layer of essential oil, as additional peaks and broadening are observed in drug-loaded Fe3O4 nanoparticles. Magnetic susceptibility values indicate the material's superparamagnetic nature. Transmission electron microscopy images have ensured that the particles were spherical, monodispersed, and in the range of 4.30 nm to 13.98 nm. Antimicrobial studies show inhibition zones on the microorganisms S. Aureus and E. Coli with enhanced activity. Drug entrapment efficiency studies revealed the encapsulation of drug molecules onto Fe3O4-Laxmitaru composite. Dynamic light scattering studies confirm the increase in hydrodynamic size, indicating the loading of essential oils and the decrease in polydispersity index ensures monodispersed nanoparticles. The antioxidant study showed the essential oils retained their antioxidant activity even after they were conjugated on Fe3O4-Lax composites. Conclusions Laxmitaru phytochemical-coated Fe3O4 nanoparticles were successfully conjugated with Eugenol and Ylang-Ylang essential oils. Our results provide a model therapeutic approach for the development of new alternative strategies for enhancing antimicrobial and antioxidant therapy, with potential advantages in the field of nanobiomedicine.

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Utilization of Nanomaterials in Target Oriented Drug Delivery Vehicles

Cited by 3 publications

References 46 publications

Glucose Functionalized Magnetic Iron Oxide Nanoparticles for Protein Detection and Separation

Glucose Functionalized Magnetic Iron Oxide Nanoparticles for Protein Detection and Separation

Polymeric Fe<sub>3</sub>O<sub>4</sub> Conjugates with Bioactive Plant Molecules: Platforms for Antimicrobial Therapy

Antimicrobial and antioxidant therapy with bioactive plant molecules on Fe3O4 phytohybrid nanoplatforms

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