Utilization of light‐emitting diodes for skin therapy: Systematic review and meta‐analysis

Abstract

Light-emitting diodes (LEDs) are semiconductor devices that produce non-coherent, non-collimated, and narrow-spectrum lights (approximately 255-1300 nm) when a forward voltage is applied. 1,2 LED devices, including blue (420-440 nm), red (630-680 nm), and yellow (590-595 nm) LED lights, as well as near-infrared (LED-NIR; 750-1200 nm), are typically applied in five fields, including indicators and signs, lighting, data communication, machine vision systems, and especially, biological applications. 2 In fact, the application of LEDs in dermatology has really attracted the attention of dermatologists and estheticians thanks to their ideal properties (photobiomodulation [PBM] reactions) as well as outstanding advantages (e.g., high compliance, convenience, simplicity, and painlessness). 2,3 In fact, a number of studies have demonstrated the benefits of LEDs in various clinical practices, such as accelerating wound healing, inhibiting infection, rejuvenating skin, treating acne and atopic dermatitis, radiation therapy, and photodynamic therapy (PDT). [3][4][5][6][7] Specifically, LEDs have been popularly integrated into PDT devices as light sources to treat a wide range of medical conditions (e.g., cancer, acne, psoriasis, atherosclerosis, and anti-viral treatments). 4 The principle of treatment is based on PBM reactions, which include

Development of a low-cost device for photobiomodulation using 3D printing

“…23 There is a large body of literature demonstrating the clinical benefits of photobiomodulation methods using lasers 24 or LED diodes. 25 However, PBM using light-emitting diodes has some advantages that should be considered when weighing the cost-effectiveness of these methods, particularly when used in public health systems where resources are generally scarce. PBM using LED therapy is, on average, much cheaper than laser devices.…”

The Role of Physical Therapies in Wound Healing and Assisted Scarring

“…Blue-light PBM triggers a cascade of events attributable to the absorption of photons by intracellular photoreceptors. Among these effects, the impact of light on cytochrome-C oxidase can be observed: it induces an increase in cell proliferation, migration and differentiation, cytokine modulation, growth factor synthesis, and anti-inflammatory effects; thus, stimulating the improvement of the healing process [59,60].…”

Ozonated Hydrotherapy Combined with LED Yellow Light Irradiation and Oral Minocycline Treatment for Mild to Moderate Papulopustular Rosacea: A Comparative Retrospective Study

“…Among them, LED yellow light, when absorbed by the skin, can treat telangiectasia, inhibit vascular neurogenic hyperreactivity, enhance skin tolerance and resistance, and reduce skin sensitivity. 11 Studies have shown that LED yellow light can inhibit the angiogenesis of human microvascular endothelial cells to improve erythema. 12 Based on this, LED yellow light may improve the itching, burning, stinging, and erythema symptoms of PPR.…”