Utilization of kinase inhibitors as novel therapeutic drug targets: A review

Abstract

Kinase inhibitors are a significant and continuously developing division of target therapeutics. The drug discovery and improvement efforts have examined numerous attempts to target the signaling pathway of kinases. The Kinase inhibitors have been heralded as a game-changer in cancer treatment. For developing kinase inhibitors as a treatment for various non-malignant disorders like auto-immune diseases, is currently undergoing extensive research.It may be beneficial to investigate whether cell-specific kinase inhibitor administration enhances therapeutic efficacy and decreases adverse effects. The goal of the current review is to gain insight into the role of kinase inhibitors in facilitating effective target drug delivery for the treatment of various anti-inflammatory, auto-immune, and anticancer disorders. The aim of this review is also to shed light on drug discovery approaches for kinase inhibitors, their mode of action, and delivery approaches. The variation in the binding of kinases bestows different target approaches in drug design, which can be employed for designing the targeted molecules. Several target sites have been studied, exceeding the design of drugs for various diseases like cancer, Alzheimer's, rheumatoid arthritis, etc. Diverse delivery approaches have also been studied for the targeted application of kinase inhibitors.

Dynamics Playing a Key Role in the Covalent Binding of Inhibitors to Focal Adhesion Kinase

“…Protein kinases constitute the second largest family of drug targets, accounting for approximately 30% of targets in the pharmaceutical industry. 1,2 Kinase drugs are predominantly reversible inhibitors. However, there has been a notable surge of interest in developing covalent kinase inhibitors (CKIs) in recent times.…”

“…Protein kinases constitute the second largest family of drug targets, accounting for approximately 30% of targets in the pharmaceutical industry. , Kinase drugs are predominantly reversible inhibitors. However, there has been a notable surge of interest in developing covalent kinase inhibitors (CKIs) in recent times. , CKIs offer distinct advantages over their reversible counterparts, offering improved potency, increased selectivity, and prolonged duration of action, which make them very attractive in kinase drug development. , To date, 10 CKIs have gained approval for therapeutic use, and several others are in various stages of clinical trials .…”

Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAFV600E Dual Inhibitors Endowed with Antiproliferative Activity

“…Kinases control many essential cancer processes, including tumor growth, metastasis, neovascularization, and treatment resistance. Hence, the development of kinase inhibitors has become a top priority, with several of them receiving FDA approval for a variety of cancer purposes [ 1 , 2 , 3 , 4 , 5 ].…”

Src Tyrosine Kinase Inhibitory and Antioxidant Activity of Black Chokeberry and Bilberry Fruit Extracts Rich in Chlorogenic Acid

“…Among these kinase inhibitors, those derived from various plant sources are also described in the literature. They belong to different classes of compounds, including polyphenols [38].…”