Utilization of GEANT to calculation of production yield for  89 Zr by charge particles interaction on  89 Y,  nat Zr and  nat Sr

Sharifian, Mozhgan; Sadeghi, Mahdi; Alirezapour, Behrouz

doi:10.1016/j.apradiso.2017.06.005

Cited by 7 publications

(1 citation statement)

References 14 publications

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“…Another advantage of zirconium-89 is that it has one of the lowest maximum energies of emitted positrons (after fluorine-18, copper-64 and carbon-11), which makes it possible to obtain PET images with high resolution [18,20]. According to the modeling results, which are in good agreement with the published experimental data, 89 Y(p,n) 89 Zr reaction is considered to be the best for producing zirconium-89, and optimum energy for proton bombardment is 14 MeV [21,22,23,24]. The reaction can be successfully performed using small biomedical cyclotrons (<20 MeV); even 11 MeV cyclotrons are suitable [25,26,27].…”

Section: Introductionmentioning

confidence: 62%

Preparation of Zirconium-89 Solutions for Radiopharmaceutical Purposes: Interrelation Between Formulation, Radiochemical Purity, Stability and Biodistribution

et al. 2019

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Zirconium-89 is a promising radionuclide for nuclear medicine. The aim of the present work was to find a suitable method for obtaining zirconium-89 solutions for radiopharmaceutical purposes. For this purpose, the ion exchange behavior of zirconium-89 solutions was studied. Radio-TLC (thin layer chromatography) and biodistribution studies were carried out to understand speciation of zirconium-89 complexes and their role in the development of new radiopharmaceuticals. Three methods of zirconium-89 isolation were studied using ZR (hydroxamate) and Chelex-100 resins. It was found that ZR-resin alone is not enough to obtain stable zirconium-89 formulations. An easy and effective method of reconstitution of [89Zr]Zr-oxalate to [89Zr]Zr-citrate using Chelex-100 resin was developed. Developed procedures allow obtaining [89Zr]Zr-oxalate (in 0.1 M sodium oxalate solution) and [89Zr]Zr-citrate (in 0.1–1.0 M sodium citrate solution). These solutions are perfectly suitable and convenient for radiopharmaceutical purposes. Our results prove [89Zr]Zr-citrate to be advantageous over [89Zr]Zr-oxalate. During evaluation of speciation of zirconium-89 complexes, a new TLC method was developed, since it was proved that there is no comprehensive method for analysis or zirconium-89 preparations. The new method provides valuable insights about the content of “active” ionic form of zirconium-89. The interrelation of the chromatographic behavior of zirconium-89 preparations and their biodistribution was studied.

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