Utilization of Experimental Design for the Establishment and Optimization of RP-HPLC Method for the Estimation of Two Selective Serotonin Reuptake Inhibitors/benzodiazepines Combinations in the Presence of their Related Compounds
Abstract:Background:
Design of experiment (DOE) is considered the most powerful tool to identify factors that affect variation and improve the response by tuning these factors. In the present work, DOE was applied to establish an innovative, sensitive and precise HPLC method for the simultaneous determination of Escitalopram oxalate, Paroxetine hydrochloride hemihydrate and Clonazepam in presence of their related compounds in drug substance and drug products.
Methods:
Buffer molarity, % organic modifier (acetonitril… Show more
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