Utilization of Existing Human Kinase Inhibitors as Scaffolds in the Development of New Antimicrobials
Monika I. Konaklieva,
Balbina J. Plotkin
Abstract:The prevalence and continuing expansion of drug resistance, both in clinical and community settings represents a major challenge for current antimicrobial therapy. The different approaches for addressing this challenge include (1) identification of novel antibacterials by repurposing of existing drugs originally that historically target host proteins; and (2) effect target switching through modification of existing antimicrobials. The focus of this manuscript is on these drug discovery strategies, with utility… Show more
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