Utilization of ancillary studies in thyroid fine needle aspirates: A synopsis of the National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference

Filie, Armando C.; Sylvia, L.; Geisinger, Kim R.; Logani, Sanjay; Merino, María J.; Nikiforov, Yuri E.; Clark, Douglas P.

doi:10.1002/dc.20831

Cited by 71 publications

(42 citation statements)

References 25 publications

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“…Nodules that demonstrate either isofunction or hypofunction on a radionuclide scan should be further assessed by ultrasound. [6][7][8][9][10] Thyroid nodules initially detected by imaging studies may require investigation by FNA, depending on their size and the type of imaging method used at the time of their initial discovery. For example, thyroid nodules incidentally detected by fluorine F 18 2-fluoro-2-deoxy-D-glucose positron emission tomography ( 18 F-FDG-PET) have a relatively high risk of malignancy, [17][18][19][20] and when uptake is localized focally within the thyroid, FNA should be performed to rule out malignancy.…”

Section: Indications For Performing An Fna Of a Thyroid Nodulementioning

confidence: 99%

“…[1][2][3][4][5] This review was based largely on the NCI conference and summarized the state of the art for indications to perform a thyroid FNA, pre-FNA requirements, diagnostic terminology, and post-FNA testing and treatment options. Summaries of committee findings for training and credentialing 6 and utilization of ancillary techniques in thyroid FNA 7 can be found elsewhere.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thyroid Aspiration Cytology: Current Status

Layfield¹,

Cibas²,

Gharib³

et al. 2009

CA: A Cancer Journal for Clinicians

154

115

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In the adult population, thyroid nodules are common and are increasingly detected by ultrasound examination or other scanning techniques. Depending on their size and ultrasonographic features, these nodules may require further investigation, including tissue diagnosis. Fine-needle aspiration (FNA) has become the predominant method to obtain tissue for microscopic analysis. In October 2007, the National Cancer Institute sponsored a conference to review the state of the science for the use of FNA in the management of thyroid nodules. This conference reviewed indications for thyroid FNA and pre-FNA requirements, training and credentialing, techniques for thyroid FNA, diagnostic terminology and morphologic criteria, utilization of ancillary studies, and post-FNA testing and treatment options. The results of those discussions have been published in both print and electronic versions. The aim of the current article was to discuss indications for FNA, diagnostic terminology, and post-FNA options, issues that are important to physicians who are managing patients with thyroid nodules. CA Cancer J Clin 2009;59: 99-110.

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Section: Indications For Performing An Fna Of a Thyroid Nodulementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thyroid Aspiration Cytology: Current Status

Layfield¹,

Cibas²,

Gharib³

et al. 2009

CA: A Cancer Journal for Clinicians

154

115

View full text Add to dashboard Cite

show abstract

“…Therefore, a multidisciplinary conference was held at the National Cancer Institute in Bethesda, Maryland, in October 2007, and the proceedings were published in June 2008. [1][2][3][4][5][6] Ultimately, a uniform, 6-tiered reporting system was proposed with defined diagnostic categories, standardized nomenclature, and predictive risk of malignant outcomes for each diagnostic category. 7,8 Since the BSRTC was introduced, the ''atypia of undetermined significance or follicular lesion of undetermined significance'' (AUS/FLUS) category has received significant attention within the cytology literature, and it has been the most controversial.…”

mentioning

confidence: 99%

Thyroid Fine-Needle Aspiration Reporting Rates and Outcomes Before and After Bethesda Implementation Within a Combined Academic and Community Hospital System

Harvey

Mody

Amrikachi

2013

Archives of Pathology &Amp; Laboratory Medicine

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Context.-The current study compares data from our hospital system before and after the 2008 implementation of the Bethesda System for Reporting Thyroid Cytology (BSRTC).Objective.-To show the effects the BSRTC has had on the reporting rates and outcomes for thyroid lesions.Design.-A search for thyroid fine-needle aspiration biopsies (FNABs) was performed for 2002-2005 (before BSRTC) and -2011. Diagnostic outcomes were reviewed for cases with available follow-up.Results. -For 2002-For -2005, cytology reports for 3302 thyroid FNABs were reviewed, and 309 (9.4%) were classified as suspicious. For 2009-2011, cytology reports for 3432 thyroid FNABs were reviewed; 72 (2.1%) were classified as ''atypia of undetermined significance or follicular lesion of undetermined significance'' (AUS/ FLUS), and 142 (4.1%) were classified as suspicious. Follow-up material was available for 31 AUS/FLUS cases (43.0%), and 6 of these cases (19%) were malignant. Follow-up material was available for 60 cases (42.3%) classified as suspicious, and 23 of these cases (38%) were malignant.Conclusions.-The AUS/FLUS rate of 2.1% at our institution is at the lower range of the ,7% recommended by the BSRTC, and our rate of 19% for risk of malignancy for AUS/FLUS is slightly above the BSRTC recommendation of 5% to 15%. Implementation of the BSRTC did not significantly affect our institution's reporting rates, most likely because an essentially similar classification system was employed before implementation of the BSRTC.

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“…The commonly found mutations in thyroid neoplasms are typically mutually exclusive. 69,131,132 Here we review the most commonly studied molecular alterations in follicular cell-derived thyroid neoplasms.…”

Section: Molecular Tests In Thyroid Lesionsmentioning

confidence: 99%

Five Top Stories in Thyroid Pathology

Moghaddam

Virk

Sakhdari

et al. 2016

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Thyroid carcinoma is the most common malignant tumor of endocrine organs, yet it only accounts for approximately 1% of all cancers in the United States with more than 35 000 new cases diagnosed each year and more than 450 000 people living with this disease. While most tumors can be diagnosed without much difficulty, a few tumor types, especially tumors with follicular pattern, sometimes pose a diagnostic challenge.Objective.-To discuss morphologic, immunohistochemical, and molecular features of thyroid tumors. We also explore the clinicopathologic features of papillary microcarcinoma and medullary microcarcinoma and how the latter is related and differentiated from C-cell hyperplasia.Finally with the ever-growing list of organ systems involved in immunoglobulin (Ig) G4-related diseases, we discuss the still not completely explored IgG-4-related thyroid disease.Data Sources.-Data were obtained from review of the pertinent peer-reviewed literature and institutional experience.Conclusions.-Histomorphologic evaluation still remains the gold standard for diagnosis in most cases of thyroid diseases. The application of ancillary studies such as immunohistochemistry and molecular diagnosis, including next-generation sequencing, is becoming more common.

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Utilization of ancillary studies in thyroid fine needle aspirates: A synopsis of the National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference

Cited by 71 publications

References 25 publications

Thyroid Aspiration Cytology: Current Status

Thyroid Aspiration Cytology: Current Status

Thyroid Fine-Needle Aspiration Reporting Rates and Outcomes Before and After Bethesda Implementation Within a Combined Academic and Community Hospital System

Five Top Stories in Thyroid Pathology

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