Utilization of amphiphilic antihistamines drugs to enhance micellization of anionic surfactant and improve the binding and solubility of Itraconazole drug

Srivastava, Anirudh; Kumar, Mukul; Deb, Debojit Kumar; Muzaffar, Faizi; Singh, Sandeepika

doi:10.1016/j.molliq.2021.118018

Cited by 20 publications

(27 citation statements)

References 58 publications

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“…A comparable noteworthy decline in CMCs of ionic surfactants in organic drugs has been reported in our group. We reported that the CMC of sodium dodecylbenzenesulfonate (SDBS) was significantly reduced in the existence of DPC and cetirizine hydrochloride (CTZ) as counterion ions …”

Section: Resultsmentioning

confidence: 99%

“…We observed uniformity in the characteristics of the plots for STS in the presence of diphenhydramine (DP + ) and chlorpheniramine (CP + ) counterions by using a modified CH equation, as shown in Figure C. The modified CH equation plot for STS-DPC and STS-CPM occurs on linear regions, comparable to the modified CH plot for SDBS-DPC and SDBS-CTZ systems …”

Section: Resultsmentioning

confidence: 99%

“…The STS system β c values were greater in the CPM than in the DPC medium. The optimal occupancy of CP+ ions in STS micelles relative to DP+ ions could influence it …”

Section: Resultsmentioning

confidence: 99%

“…Shah and Flanagan evaluated the impact of self-associations of antihistamine drug salts on the dissolution of salicylamide and acetaminophen in water-based solutions. We have reported that DPC and cetirizine hydrochloride (CTZ) drugs were used as organic counterions to reduce the CMC ionic surfactants. , We observed that counterions reduced the CMC of sodium dilauramidoglutamide lysine (SDGL), sodium dodecyl sulfate (SDS), and sodium dodecylbenzenesulfonate (SDBS). Another use of ionic drugs (CTZ, CPM, and DPC) as counterions in surfactant interactions was to increase the attraction and occupancy of poorly water-soluble drugs, such as anti-inflammatory (ethenzamide, ibuprofen) and antifungal drugs (clotrimazole and itraconazole). , …”

Section: Introductionmentioning

confidence: 99%

“…7−12 Ionic medications have grown in importance recently as organic counterions or additions to enhance the interfacial and micellization properties of a charged surfactant and also to boost the concentration of pharmaceuticals that are only partially dissolved in the aqueous medium. 13,14 Whenever there are extra ingredients such as electrolytes, the critical micelle concentration (CMC) of the surfactants decreases. 15,16 Since they decrease their efficacy surface area per headgroup by limiting undesirable contact between each headgroup, additives, remarkably, make it simpler to induce an appearance change in surfactant micelles.…”

Section: Introductionmentioning

confidence: 99%

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Counterion Association of Ionic Drugs with Sodium Tetradecyl Sulfate in the Aqueous Medium

Kumar,

Bhardwaj,

Elahi

et al. 2023

ACS Omega

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…The STS system β c values were greater in the CPM than in the DPC medium. The optimal occupancy of CP+ ions in STS micelles relative to DP+ ions could influence it …”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Counterion Association of Ionic Drugs with Sodium Tetradecyl Sulfate in the Aqueous Medium

Kumar,

Bhardwaj,

Elahi

et al. 2023

ACS Omega

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Binding and occupancy properties of gabapentin in mixed surfactant systems

Kumar,

Khushi,

Singh

et al. 2023

J Surfact & Detergents

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This research highlights the efficacy of mixed micellar systems as an innovative chemical formulation for improving the binding properties of active pharmaceutical drugs. The formulations based on the mole fraction were utilized for preparing mixed micelles with anionic sodium dioctyl sulfosuccinate (AOT) and sodium dodecyl sulphate (SDS). DLS measurements demonstrated the formation of small micelles and mixed micelles in SDS‐AOT combinations. A UV absorbance investigation demonstrated the effectiveness of the SDS‐AOT mixed micelles for determining the binding constant (Kb) and mean ion occupancy (i0) of the anticonvulsant gabapentin (GBP) drug. Kb values increased, but the occupancy (i) of GBP per micelle decreased by decreasing the mole fraction (α) of SDS from αSDS 0.9 to 0.1, predicting a shift in occupancy of drugs from the Palisade to the Stern layer. To get a better comprehension of micellization behavior and preferential interaction of the drugs under study, molecular docking studies were performed. According to the docking studies, the GBP displayed significant binding in the presence of SDS‐AOT when compared to pure SDS and AOT molecules. Ultimately, in pharmaceutical applications, mixed micelle played an important role in enhancing the binding and encapsulation efficiency of drugs.

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Molecular interaction of nonsteroidal anti‐inflammatory prodrug nepafenac with ionic surfactants

Abbas,

Shafqat,

Nazar

et al. 2024

Int J of Chemical Kinetics

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Drug‐surfactant interaction increases the solubility of poorly water‐soluble drugs and design better pharmaceutical formulations. The degree of interaction of nepafenac (NP), a nonsteroidal anti‐inflammatory prodrug was studied with ionic surfactant molecules such as cationic surfactant cetrytrimethyl ammonium bromide (CTAB) and anionic surfactant sodium dodecyl sulphate (SDS) in an aqueous medium at room temperature. NP made mixed micelles with CTAB and SDS. To investigate the influence of interactions, conductivity measurements, UV–visible spectroscopy, and fluorescence measurements were recorded. The quantification of NP–surfactant interactions was investigated using various mathematical models. The CMC values determined from conductivity measurements of pure surfactants were 0.96 mM for CTAB and 8.14 mM for SDS near to their literature values. At different mole fractions of NP in UV measurements, binding constants from lnKb were found 0.025 and 0.123 and number of NP molecules per micelles (n) 67, 46 for CTAB and SDS, respectively. The mixed micelles of NP–CTAB and NP–SDS revealed that CTAB has a strong interaction with NP than SDS. The Benesi–Hildebrand relationship, Stern–Volmer and Kawamura replica for the partition coefficient were used to confirm the findings. We are confident that the host–guest interaction mechanism can contribute to a better understanding of molecular recognition in the phospholipid membrane model.

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Utilization of amphiphilic antihistamines drugs to enhance micellization of anionic surfactant and improve the binding and solubility of Itraconazole drug

Cited by 20 publications

References 58 publications

Counterion Association of Ionic Drugs with Sodium Tetradecyl Sulfate in the Aqueous Medium

Counterion Association of Ionic Drugs with Sodium Tetradecyl Sulfate in the Aqueous Medium

Binding and occupancy properties of gabapentin in mixed surfactant systems

Molecular interaction of nonsteroidal anti‐inflammatory prodrug nepafenac with ionic surfactants

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