Utilization management in toxicology

Zhang, Yan; Kwong, Tai C.

doi:10.1016/j.cca.2013.09.039

Cited by 13 publications

(6 citation statements)

References 53 publications

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“…One group of physicians is not convinced that TST-U have much added value, and will rarely use them [15] , [20] , [21] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] . The other group finds TST-U a useful diagnostic tool, because they provide confirmation and/or reassurance [17] , [18] , [19] , [33] , [34] , [35] , [36] , [37] .…”

Section: Discussionmentioning

confidence: 99%

Clinical value of drugs of abuse point of care testing in an emergency department setting

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Clinical value of drugs of abuse point of care testing in an emergency department setting

et al. 2018

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“…[77][78][79] However, immunoassays for drugs of abuse have poor specificity (inaccuracy), and there is no correlation between the presence of drugs or metabolites in the urine and toxic effects or clinical impairment. 80 Point-of-care testing is based on immunochromatography, in which a drug in the patient's sample competes with drug and antibody conjugates in the test to allow or block development of a colored line; most POCT is visually interpreted in a few minutes. 81 An optimal screening test is not an optimal diagnostic test, and urine drug screens are primarily designed as a screening test.…”

Section: Clinical Chemistrymentioning

confidence: 99%

Current Status of Clinical Application of Point-of-Care Testing

Park

2020

Archives of Pathology &Amp; Laboratory Medicine

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Context.— The clinical applications of point-of-care testing (POCT) are gradually increasing in many health care systems. Recently, POCT devices using molecular genetic method techniques have been developed. We need to examine clinical pathways to see where POCT can be applied to improve them. Objective.— To introduce up-to-date POCT items and equipment and to provide the content that should be prepared for clinical application of POCT. Data Sources.— Literature review based on PubMed searches containing the terms point-of-care testing, clinical chemistry, diagnostic hematology, and clinical microbiology. Conclusions.— If medical resources are limited, POCT can help clinicians make quick medical decisions. As POCT technology improves and menus expand, areas where POCT can be applied will also increase. We need to understand the limitations of POCTs so that they can be optimally used to improve patient management.

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“…The rapid identification of different compounds represents a challenge for emergency laboratories. Therefore, the analytical strategy should focus on developing features such as simultaneous monitoring of a large number of drugs, simplicity, low cost and a rapid sample preparation (Maurer, ; Uges, ; Vincenti et al, ; Zhang & Kwong, ). Several articles have been published using different procedures for the detection of different analytes of interest in clinical toxicology (Domingues et al, ; Meyer, Welter, Weber, & Maurer, ; Remane, Meyer, Peters, Wissenbach, & Maurer, ; Zhang & Kwong, ).…”

Section: Introductionmentioning

confidence: 99%

Development of a simple HPLC‐DAD multi‐analyte procedure and its application in cases evaluated by the Poison Control Center of São Paulo, Brazil

Oliveira

Zucoloto

Oliveira³

et al. 2018

Biomedical Chromatography

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This work describes a simple approach to overcome challenges in emergency toxicological analysis, using liquid-liquid extraction and high-performance liquid chromatography coupled with a diode-array detector (HPLC-DAD). A rapid procedure has been developed, for the extraction and detection of 19 analytes from the following drug classes: analgesics, benzodiazepines, antidepressants, anticonvulsants and drugs of abuse. These substances are relevant in the context of emergency toxicology in Brazil. The method has been validated according to international guidelines by establishing parameters such as lower limit of quantification, sensitivity, linearity, accuracy and precision. The intra and inter-day precision values, at the lowest concentration levels, have always been less than 20% considering its relative standard deviation. As for accuracy values, these have also been satisfactory (above 81.3%). This method was successfully applied in 201 blood samples from patients with suspected poisoning of the Poison Control Center of São Paulo (PCC-SP), Brazil. Finally, the developed method has shown to be relevant for emergency toxicology due to its high sensitivity and it could be also very useful in both fields of clinical and forensic toxicology.

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Utilization management in toxicology

Cited by 13 publications

References 53 publications

Clinical value of drugs of abuse point of care testing in an emergency department setting

Clinical value of drugs of abuse point of care testing in an emergency department setting

Current Status of Clinical Application of Point-of-Care Testing

Development of a simple HPLC‐DAD multi‐analyte procedure and its application in cases evaluated by the Poison Control Center of São Paulo, Brazil

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