Utilização do leito de jorro para a aplicação de revestimento entérico em cápsulas gelatinosas duras

Abstract

Apresenta INTRODUÇÃOAs cápsulas gelatinosas duras têm sofrido significativo aumento na sua comercialização e, atualmente, essa forma farmacêutica possui grande aceitação, constituindo, ao lado dos comprimidos, as formas farmacêuticas mais utilizadas de administração oral de medicamentos (Pina et al., 1996(Pina et al., , 1997. Esse crescimento na comercialização deve-se principalmente às vantagens de manipulação e administração atribuídas a esse produto.Entretanto, algumas desvantagens são associadas a esta forma farmacêutica, que incluem a impossibilidade de utilização de drogas que se oxidam e/ou que são degradadas ou inativadas em meio ácido, como por exemplo, hormônios, peptídeos e enzimas. Existem situações em que o fármaco pode irritar a mucosa gástrica, causando ná-

Study of a delayed-release system for hard and soft capsules coated with eudragit® s100 acrylic polymers

“…Due to the hot air, the liquid evaporates, and the solid forms a shell enclosing the kernel material (Hampel et al, 2013). The spray drying (spouted bed) coating method is an excellent technique for polymer application on capsules and tablets and can be used at an industrial scale (Martins & Oliveira, 2003).…”

“…Protection from light and humidity are among their main advantages. They are also easily administered, enable combining normally incompatible substances and can mask the unpleasant flavour and/or odour of medicines (Martins & Oliveira, 2003). Hard capsules ( Figure 3A) are also easily administered, and they are versatile because they allow the extemporaneous preparation of the most diverse formulations in individual doses.…”

“…Coating is defined as the process of applying a layer of material on a pharmaceutical form (solid surface) with a pharmaceutical composition (Martins & Oliveira, 2003). Coating is an adaptation of food preservation methods Pharmaceutical forms are primarily coated for active ingredient protection (Hampel, Buck, Peglow, & Tsotsas, 2013), and coating was first used by the pharmaceutical industry in 1953, when the Abbot Laboratory developed the first film coating (Lachman, Lieberman, & Kanig, 2001).…”

<b>The importance of coating standardization in gastro-resistant capsules produced in magistral pharmacy</b> - doi: 10.4025/actascihealthsci.v35i2.14581

“…The production of hard gelatin capsules is on the increase. In fact, the above pharmaceutical mode is highly accepted and, similar to tablets, it is currently the most common mode of oral drug administration (MARTINS;OLIVEIRA, 2003;PINA et al, 1996PINA et al, , 1997.…”

“…This may occur through the disintegration of the capsule and the dissolution of the drug in neutral and/or base pH (rates may be found in the enteric medium) which may be obtained by applying a gastroresistant coating. Since the literature provides few studies on coating application in such pharmaceutical forms, the development of methods for the coating of hard gelatin capsules is a promising research field (MARTINS;OLIVEIRA, 2003).…”