“…A recurring factor reported to influence the quality of a trial positively was that statisticians should be involved from the beginning and in every stage through to the reporting [ 25 , 28 , 30 , 33 , 42 , [47] , [48] , [49] , [50] ]; Meeks et al, 2018). Recognising the importance of statistical expertise and early collaboration between statisticians, investigators and the clinical data management team was a key finding identified across several articles [ 26 , 40 ]; Crewson and Applegate., 2001 [ 29 , 35 , [51] , [52] , [53] , [54] ]; Meeks et al, 2018; [ 55 ].…”