Utility Serum Marker HE4 for the Differential Diagnosis Between Endometriosis and Adnexal Malignancy

Zapardiel, Ignacio; Gorostidi, Mikel; Ravaggi, Antonella; Allende, M.T.; Silveira, Margarida; Abehsera, Daniel; Macuks, Ronalds

doi:10.1097/igc.0000000000000579

Cited by 8 publications

(7 citation statements)

References 13 publications

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“…Human epididymis protein 4 (HE4) may, in combination with CA125, offer new possibilities for noninvasive discrimination between malignant and benign pelvic diseases [ 43 ], including endometriosis [ 55 ]. The peritoneal fluid of our endometriosis patient collective showed decreased values of HE4.…”

Section: Discussionmentioning

confidence: 99%

Does the Use of the “Proseek® Multiplex Oncology I Panel” on Peritoneal Fluid Allow a Better Insight in the Pathophysiology of Endometriosis, and in Particular Deep-Infiltrating Endometriosis?

Perricos

Wenzl

Husslein

et al. 2020

JCM

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Endometriosis appears to share certain cancer-related processes, such as cell attachment, invasion, proliferation and neovascularization, some of which can also be found in other healthy tissues. In order to better understand the altered milieu of the peritoneal cavity, while acknowledging the reported similarities between endometriosis and neoplastic processes, we applied a multiplex oncology panel to search for specific biomarker signatures in the peritoneal fluid of women with endometriosis, women with deep-infiltrating endometriosis (DIE), as well as controls. In total, 84 patients were included in our study, 53 women with endometriosis and 31 controls. Ninety-two proteins were measured in prospectively collected peritoneal fluid (PF) samples, using the “Proseek® Multiplex Oncology I Panel”. We first compared patients with endometriosis versus controls, and in a second step, DIE versus endometriosis patients without DIE. Out of the 92 analyzed proteins, few showed significant differences between the groups. In patients with endometriosis, ICOS ligand, Endothelial growth factor, E-selectin, Receptor tyrosine-protein kinase erbB-2, Interleukin-6 receptor alpha, Vascular endothelial growth factor receptor 2, Fms-related tyrosine kinase 3 ligand, C-X-C motif chemokine 10, Epididymal secretory protein E4 and Folate receptor-alpha were decreased, while Interleukin-6 and Interleukin-8 were increased compared to controls. Looking at patients with DIE, we found Chemokine ligand 19, Stem cell factor, Vascular endothelial growth factor D, Interleukin-6 receptor alpha and Melanoma inhibitory activity to be increased compared to endometriosis patients without DIE. We have shown a distinct regulation of the immune response, angiogenesis, cell proliferation, cell adhesion and inhibition of apoptosis in PF of patients with endometriosis compared to controls. The specific protein pattern in the PF of DIE patients provides new evidence that DIE represents a unique entity of extrauterine endometriosis with enhanced angiogenetic and pro-proliferative features.

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Section: Discussionmentioning

confidence: 99%

Does the Use of the “Proseek® Multiplex Oncology I Panel” on Peritoneal Fluid Allow a Better Insight in the Pathophysiology of Endometriosis, and in Particular Deep-Infiltrating Endometriosis?

Perricos

Wenzl

Husslein

et al. 2020

JCM

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“…Sensitivity of HE4 and CA-125 for discriminating ovarian cancer from benign pathologies was 86.2% and 93.1% for ROMA and the specificity was 87.4, 78.9 and 90.7 % for HE4, Ca-125 and ROMA ( 18 ). Since CA-125 is a nonspecific tumor marker, it is shown that determination of HE4 while there is a high level of CA-125 levels could confirm the benign nature of ovarian endometrioma ( 19 , 20 ).…”

Section: Discussionmentioning

confidence: 99%

Adnexal mass with extremely high levels of CA-125 and CA19-9 but normal Human Epididymis Protein 4 (HE4) and Risk of Ovarian Malignancy Algorithm (ROMA): Endometriosis or ovarian malignancy? A case report

Khodaverdi

Aminimoghaddam

Nokiani

et al. 2018

IJRM

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Background:It has been shown that Carbohydrate antigen (CA) 125 and CA 19-9 tumor markers are useful for diagnosis and follow up of ovarian carcinoma.Case:In this case, we reported the high level of CA-125 and CA 19-9 with large right ovarian intact endometrioma and extensive involvement of omentum.Conclusion:Human Epididymis protein (HE4) and Risk of ovarian malignancy algorithm (ROMA) can be useful in differentiation between malignancies and benign pathologies with a good sensitivity and specificity value.

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“…Comparison of both HE4 and CA125 markers favors HE4 over CA125, mainly because even when both markers are increased in nontreated patients, hormone treatment returns concentration of CA125 to normal levels, but concentration of HE4 is significantly below the control levels (McKinnon et al, 2015). A multicentric study in four European centers showed that HE4 is a useful biomarker for excluding malignant disease in patients with endometriosis (Zapardiel et al, 2016). On the other hand, some studies showed no elevation of HE4 levels in endometriosis (Jacob et al, 2010), making the use of this biomarker doubtful.…”

Section: Human Epididymis Proteinmentioning

confidence: 99%

Endometriosis-Search for Biomarkers

Králíčková¹,

Větvička²

2016

American Journal of Immunology

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Utility Serum Marker HE4 for the Differential Diagnosis Between Endometriosis and Adnexal Malignancy

Abstract: HE4 can be a very useful biomarker to exclude malignant disease in patients with endometriosis.

Cited by 8 publications

References 13 publications

Does the Use of the “Proseek® Multiplex Oncology I Panel” on Peritoneal Fluid Allow a Better Insight in the Pathophysiology of Endometriosis, and in Particular Deep-Infiltrating Endometriosis?

Does the Use of the “Proseek® Multiplex Oncology I Panel” on Peritoneal Fluid Allow a Better Insight in the Pathophysiology of Endometriosis, and in Particular Deep-Infiltrating Endometriosis?

Adnexal mass with extremely high levels of CA-125 and CA19-9 but normal Human Epididymis Protein 4 (HE4) and Risk of Ovarian Malignancy Algorithm (ROMA): Endometriosis or ovarian malignancy? A case report

Endometriosis-Search for Biomarkers

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