Utility of γ-Glutamyl Transferase in Predicting Troponin Elevation in Emergency Departments

Demirelli, Selami; Fırtına, Serdar; Aşkın, Lütfü; Gür, Sultan Tuna Akgöl; Tanrıkulu, Ceren Şen; Ermis, Emrah; İpek, Emrah; Kalkan, Kamuran; Yıldırım, Erkan; Kızıltunç, Ahmet

doi:10.1177/0003319715613923

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…Quite a few studies also have shown the usefulness of GGT in predicting Troponin elevation in acute coronary syndrome patients. 25,26…”

Section: Discussionmentioning

confidence: 99%

Comparison of Gamma-glutamyl Transferase and Troponin-I Levels in Patients Presenting with Acute Coronary Syndrome

N¹,

Krishnan²

2018

Indian Journal of Medical Biochemistry

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Introduction: Atherosclerosis is the predominant cause of acute coronary syndrome, and is usually associated with rupture of an atherosclerotic plaque resulting in the formation of partial or complete thrombosis of the coronary artery. The main objective of the study is to compare the levels of biochemical marker of atherosclerosis-gamma-glutamyl transferase (GGT) and sensitive marker of myocardial necrosis-cardiac Troponin-I (cTnI) in patients presenting with acute coronary syndrome (ACS). Materials and methods:The design was a prospective casecontrol study where a total of 161 patients, 110 ACS patients and 51 control subjects with the age group of 30 to 80 years were enrolled for the study. GGT was estimated by kinetic colour test using Beckman Coulter AU2700 analyser. Troponin-I was estimated by chemiluminescent micro particle immunoassay using Abbott ARCHITECT system. Results:The mean GGT levels of ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI) and unstable angina (UA) subgroups were 91.58, 84.12 and 30.46 U/L respectively, which showed a statistically significant difference (p < 0.001) when compared with control subjects. The mean Troponin-I levels of STEMI, NSTEMI and UA subgroups were 14.31, 4.68 and 0.02 ng/mL respectively, which showed a statistically significant difference (p < 0.001) when compared with control subjects. Correlation between GGT and Troponin-I done using Spearman's Rho coefficient correlation test showed a positive correlation between GGT and Troponin-I in ACS patients. Conclusion:Gamma-glutamyl transferase (GGT) level elevates as an indicator of increased oxidative stress in patients with coronary artery disease who are not alcoholic and have no liver disease. The strong correlation between GGT and Troponin-I complement the usefulness of gamma-glutamyl transferase for predicting troponin positivity in patients presenting with acute coronary syndrome.

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“…Quite a few studies also have shown the usefulness of GGT in predicting Troponin elevation in acute coronary syndrome patients. 25,26…”

Section: Discussionmentioning

confidence: 99%

Comparison of Gamma-glutamyl Transferase and Troponin-I Levels in Patients Presenting with Acute Coronary Syndrome

N¹,

Krishnan²

2018

Indian Journal of Medical Biochemistry

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The Value of Gamma Glutamyltransferase in Predicting Myocardial Infarction in Patients With Acute Coronary Syndrome

et al. 2017

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Comparison of Prognostic Value of 10 Biochemical Indices at Admission for Prediction Postoperative Myocardial Injury and Hospital Mortality in Patients with Osteoporotic Hip Fracture

Fisher

Srikusalanukul

Fisher

et al. 2022

JCM

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Aim: To evaluate the prognostic impact at admission of 10 biochemical indices for prediction postoperative myocardial injury (PMI) and/or hospital death in hip fracture (HF) patients. Methods: In 1273 consecutive patients with HF (mean age 82.9 ± 8.7 years, 73.5% women), clinical and laboratory parameters were collected prospectively, and outcomes were recorded. Multiple logistic regression and receiver-operating characteristic analyses (the area under the curve, AUC) were preformed, the number needed to predict (NNP) outcome was calculated. Results: Age ≥ 80 years and IHD were the most prominent clinical factors associated with both PMI (with cardiac troponin I rise) and in-hospital death. PMI occurred in 555 (43.6%) patients and contributed to 80.3% (49/61) of all deaths (mortality rate 8.8% vs.1.9% in non-PMI patients). The most accurate biochemical predictive markers were parathyroid hormone > 6.8 pmol/l, urea > 7.5 mmol/l, 25(OH)vitamin D < 25 nmol/l, albumin < 33 g/l, and ratios gamma-glutamyl transferase (GGT) to alanine aminotransferase > 2.5, urea/albumin ≥ 2.0 and GGT/albumin ≥ 7.0; the AUC for developing PMI ranged between 0.782 and 0.742 (NNP: 1.84–2.13), the AUC for fatal outcome ranged from 0.803 to 0.722, (NNP: 3.77–9.52). Conclusions: In HF patients, easily accessible biochemical indices at admission substantially improve prediction of hospital outcomes, especially in the aged > 80 years with IHD.

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Utility of γ-Glutamyl Transferase in Predicting Troponin Elevation in Emergency Departments

Cited by 3 publications

References 28 publications

Comparison of Gamma-glutamyl Transferase and Troponin-I Levels in Patients Presenting with Acute Coronary Syndrome

Comparison of Gamma-glutamyl Transferase and Troponin-I Levels in Patients Presenting with Acute Coronary Syndrome

The Value of Gamma Glutamyltransferase in Predicting Myocardial Infarction in Patients With Acute Coronary Syndrome

Comparison of Prognostic Value of 10 Biochemical Indices at Admission for Prediction Postoperative Myocardial Injury and Hospital Mortality in Patients with Osteoporotic Hip Fracture

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