Utility of Whole Body 18F-FDG PET/CT in Comparison to Pelvic MRI in Evaluation of Local Staging of Early-Stage Carcinoma Cervix

Singaram, Nagesh Kumar; Hulikal, Narendra; Devi, B Vijayalakshmi; Manthri, Ranadheer Gupta; Chowhan, Amit Kumar

doi:10.7759/cureus.32111

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…In the present study, we evaluated the diagnostic accuracy of FDG PET/CT versus FDG PET/MRI in staging and diagnosing CC. A total of eight FDG PET/CT or PET/MRI studies focusing on CC staging were reviewed [106][107][108][109][110][111][112][113]. The study by Anner et al in 2018 found that PET/MRI exhibited slightly superior results compared to PET/CT in terms of specificity (77% vs. 69%), positive predictive value (PPV) (75% vs. 69%), and negative predictive value (NPV) (67% vs. 64%) [106].…”

Section: Staging or Diagnosis Of Primary CCmentioning

confidence: 99%

18F-FDG PET/MRI and 18F-FDG PET/CT for the Management of Gynecological Malignancies: A Comprehensive Review of the Literature

Allahqoli,

Hakimi,

Laganà

et al. 2023

J. Imaging

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Objective: Positron emission tomography with 2-deoxy-2-[fluorine-18] fluoro- D-glucose integrated with computed tomography (18F-FDG PET/CT) or magnetic resonance imaging (18F-FDG PET/MRI) has emerged as a promising tool for managing various types of cancer. This review study was conducted to investigate the role of 18F- FDG PET/CT and FDG PET/MRI in the management of gynecological malignancies. Search strategy: We searched for relevant articles in the three databases PubMed/MEDLINE, Scopus, and Web of Science. Selection criteria: All studies reporting data on the FDG PET/CT and FDG PET MRI in the management of gynecological cancer, performed anywhere in the world and published exclusively in the English language, were included in the present study. Data collection and analysis: We used the EndNote software (EndNote X8.1, Thomson Reuters) to list the studies and screen them on the basis of the inclusion criteria. Data, including first author, publication year, sample size, clinical application, imaging type, and main result, were extracted and tabulated in Excel. The sensitivity, specificity, and diagnostic accuracy of the modalities were extracted and summarized. Main results: After screening 988 records, 166 studies published between 2004 and 2022 were included, covering various methodologies. Studies were divided into the following five categories: the role of FDG PET/CT and FDG-PET/MRI in the management of: (a) endometrial cancer (n = 30); (b) ovarian cancer (n = 60); (c) cervical cancer (n = 50); (d) vulvar and vagina cancers (n = 12); and (e) gynecological cancers (n = 14). Conclusions: FDG PET/CT and FDG PET/MRI have demonstrated potential as non-invasive imaging tools for enhancing the management of gynecological malignancies. Nevertheless, certain associated challenges warrant attention.

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Section: Staging or Diagnosis Of Primary CCmentioning

confidence: 99%

18F-FDG PET/MRI and 18F-FDG PET/CT for the Management of Gynecological Malignancies: A Comprehensive Review of the Literature

Allahqoli,

Hakimi,

Laganà

et al. 2023

J. Imaging

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“…Существует значительная разница в выживаемости между пациентами с наличием метастазов в лимфатических узлах (ЛУ) и отсутствием поражения ЛУ (90% против 50%) [2].…”

Section: Introductionunclassified

“…Позитронно-эмиссионная томография всего тела с использованием дезокси-[фтор-18]-глюкозы, интегрированная с компьютерной томографией ( 18 F-ФДГ-ПЭТ/КТ), объединяет возможности анатомической и функциональной визуализации [2].…”

Section: Introductionunclassified

Comparison of the Possibilities of MRI and PET/CT in Detecting Metastatic Lesion of Lymph Nodes in Cervical Cancer

Жук¹

2023

Евразийский Онкологический Журнал

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Цель. Сравнение возможностей позитронно-эмиссионной томографии, совмещенной с компьютерной томографией (ПЭТ/КТ), и магнитно-резонансной томографии (МРТ) с применением стандартного критерия (размер по короткой оси ≥1,0 см) и математической модели для выявления метастатического поражения лимфатических узлов (ЛУ) при раке шейки матки (РШМ). Материалы и методы. В исследование включены данные 108 пациентов с гистологически подтвержденным диагнозом РШМ, пролеченных хирургическим методом и консервативно, которым для оценки распространенности процесса и результатов лечения выполнены МРТ и ПЭТ/КТ. Для оценки возможностей методов в выявлении метастазов анализу подверглись 220 ЛУ. Данные ПЭТ/КТ и МРТ с применением стандартного критерия и математической модели сравнивали с результатами морфологического исследования резецированных препаратов, а также с данными динамического наблюдения (медиана наблюдения составила 8 месяцев). Для оценки диагностической эффективности методов были построены ROC-кривые (Receiver Operating Characteristic curve – ROC) с расчетом площадей под ними (Area Under Curve – AUC), определены диагностическая чувствительность (ДЧ), диагностическая специфичность (ДС), диагностическая точность (ДТ), позитивное предсказательное значение (ППЗ), негативное предсказательное значение (НПЗ). Результаты. ДЧ и ДТ МРТ математической модели составили 92,0%, 93,2% соответственно, значимо превосходили ДЧ и ДТ МРТ стандартного критерия (59,9% и 74,5% соответственно) (р<0,001) и были статистически сопоставимы с ДЧ и ДТ ПЭТ/КТ 97,8% и 96,8% соответственно) (р>0,05). AUC математической модели 0,936 значимо превосходила AUC стандартного критерия – 0,793 (р<0,05) и была сопоставима с AUC ПЭТ/КТ – 0,965 (р>0,05). Для ЛУ размером меньше 1 см по короткой оси AUC математической модели 0,876 сопоставима с AUC ПЭТ/КТ – 0,948 (р>0,05). Заключение. Математическая модель имеет высокую прогностическую ценность для выявления метастазов в ЛУ, сопоставимую с ПЭТ/КТ в том числе для ЛУ размером по короткой оси меньше 1 см. Purpose. Comparison of the capabilities of Positron Emission Tomography and Computed Tomography (PET/CT) and magnetic resonance imaging (MRI) using a standard criterion (size along the short axis D ≥1.0 cm) and a mathematical model for the detection of metastatic lesions of the lymph nodes (LN) in cervical cancer (CC). Materials and methods. The study included data from 108 patients with a histologically confirmed diagnosis of СС, treated surgically and conservatively, who underwent MRI and PET/CT to assess the prevalence of the tumor and the results of treatment. To assess the capabilities of the methods in detecting metastatic lesions, 220 LNs were analyzed. PET/ CT and MRI data using a standard criterion and a mathematical model were compared with the results of a morphological study of resected preparations, as well as with dynamic follow-up data (median follow-up was 8 months). To assess the diagnostic efficiency of the methods, ROC-curves (Receiver Operating Characteristic curve – ROC) were constructed, with the calculation of the areas under them (Area Under Curve – AUC), sensitivity (Se), specificity (Sp), accuracy, positive predictive value. negative predictive value were determined. Results. Se and accuracy MRI of the mathematical model were 92.0%, 93.2%, respectively, significantly exceeded the Se and accuracy MRI of the standard criterion (59.9% and 74.5%, respectively) and were statistically comparable with Se and accuracy PET/CT (97.8% and 96.8%, respectively). The AUC of the mathematical model was 0.936 significantly exceeded the AUC of the standard criterion 0.793 (p<0.05) and was comparable to the AUC of PET/CT 0.965 (p>0.05). For LNs smaller than 1 cm along the short axis, the AUC of the mathematical model was 0.876 and was also comparable to the PET/CT AUC 0.948 (р>0.05). Conclusion. The mathematical model has a high prognostic value for detecting LN metastases, comparable to PET/CT, including for LNs with a short axis size of less than 1 cm.

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Utility of Whole Body 18F-FDG PET/CT in Comparison to Pelvic MRI in Evaluation of Local Staging of Early-Stage Carcinoma Cervix

Cited by 2 publications

References 15 publications

18F-FDG PET/MRI and 18F-FDG PET/CT for the Management of Gynecological Malignancies: A Comprehensive Review of the Literature

18F-FDG PET/MRI and 18F-FDG PET/CT for the Management of Gynecological Malignancies: A Comprehensive Review of the Literature

Comparison of the Possibilities of MRI and PET/CT in Detecting Metastatic Lesion of Lymph Nodes in Cervical Cancer

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