Utility of transoral motion‐mode ultrasonography to detect tongue fasciculation in patients with amyotrophic lateral sclerosis

Hagiwara, Yuta; Shimizu, Takahiro; Yanagisawa, Toshiyuki; Akasu, Yukari; Kaburagi, Kei; Kikuchi, Takayuki; Shibata, Soichiro; Matsumoto, Hirofumi; Soga, Kaima; Tsuchihashi, Yoko; Nagasaka, Misako; Sasaki, Naoshi; Maki, Futaba; Shiraishi, Makoto; Akiyama, Hisanao; Hasegawa, Yasuhiro; Yamano, Yoshihisa

doi:10.1002/mus.27218

Cited by 6 publications

(5 citation statements)

References 13 publications

(30 reference statements)

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“…US may represent a useful tool also for the detection of tongue fasciculations as a non-invasive and less painful method, compared to electromyography. It may have a supporting role in the diagnosing of ALS [ 51 , 52 ]. Specifically, in ALS, early stage fasciculations are important indicators of acute denervation and development of dysphagia in those patients [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

Application of Ultrasonography in Neurogenic Dysphagia: A Systematic Review

et al. 2022

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Swallowing disorders are common in neurological diseases, with dysphagia representing one of the most prevalent complications that may cause poor quality of life, reduce independence, and increase mortality. Rapid identification of dysphagia is necessary to reduce the risk of penetration and aspiration, and to early start rehabilitation protocols. Among the methods that can be used to evaluate dysphagia and its components, ultrasound imaging has been suggested to support the evaluation of dysphagia by providing measures of both static and dynamic anatomical components. The aim of this systematic review is to evaluate the usefulness of ultrasonography in neurogenic dysphagia according to current literature. From 2000 to 2020, 633 studies with the appropriate search terms for ultrasound and dysphagia were identified. After screening them, 10 studies were included in the qualitative analysis. Patients with the following neurologic conditions were studied with ultrasonography for dysphagia: Parkinson’s disease, muscle dystrophy, amyotrophic lateral sclerosis, and stroke. The main outcomes of ultrasonography were swallowing muscles thickness (e.g., tongue), and dynamic measures such as hyoid displacement. The different protocols used in the studies, as well as their outcomes, did not allow to provide standard procedures and normative or cut-off values in the presented diseases. Because there are a variety of tools, methods, and techniques that have been used in the studies that were reviewed, it is difficult to evaluate them using established standards. However, ultrasonography correlates well with clinical evaluation of dysphagia and therefore has prognostic and rehabilitation potential. Future studies should aim to develop and utilize a common interdisciplinary protocol that includes standard procedures and outcomes to define normative values applicable in the different conditions.

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Section: Resultsmentioning

confidence: 99%

Application of Ultrasonography in Neurogenic Dysphagia: A Systematic Review

et al. 2022

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“…Während bei der Extremitäten-Muskulatur eine Beobachtung des gesamten Muskel-Querschnitts im B-Modus ein größeres Untersuchungsvolumen ermöglicht, kann für die Detektion von Zungenfaszikulationen die Verwendung des M-Modus vorteilhaft sein. Während die Mundbodenmuskulatur klassischerweise mittels Linearschallkopf von inframandibulär aufgenommen wird, scheint die Muskelsonographie der Zunge mittels transoraler Anwendung eines Stabschallkopfes noch einfacher zu sein, wobei dieser jedoch in den meisten neurologischen Praxen und Kliniken nicht zur Verfügung steht [24]. Insgesamt zeigt die Muskelsonographie zur Faszikulationsdetektion eine hohe Intra-und Interrater-Übereinstimmung [19,25].…”

Section: Sensitivität Und Spezifität Der Muskel-sonographieunclassified

Bedeutung der Muskelsonographie in der Detektion von Faszikulationen bei der ALS

German

Türk

Schramm

et al. 2023

Klinische Neurophysiologie

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ZusammenfassungBei der amyotrophen Lateralsklerose sind Faszikulationen häufig bereits in frühen Stadien in mehreren Körperregionen vorzufinden und haben daher Eingang in die entsprechenden Leitlinien und Diagnosekriterien gefunden. Während die invasive EMG-Diagnostik unverzichtbar zum Nachweis von akut- und chronisch-neurogenen Veränderungen des elektrischen Signalverhaltens motorischer Einheiten und zur Bestätigung von Faszikulationspotenzialen bleibt, bietet die Muskelsonographie ein hochsensitives Verfahren, um schnell und nicht-invasiv Faszikulationen in den verschiedenen Muskel-Etagen zu erfassen. In dieser Übersichtsarbeit stellen wir die bisherigen Daten zum Einsatz der Muskelsonographie zur Faszikulationsdetektion dar. Durch ihren Einsatz ermöglicht die Muskelsonographie im klinischen Alltag eine zielgerichtete und hierdurch aussagekräftigere EMG-Diagnostik. Aktuelle Forschungsstudien zielen darauf ab, Faszikulationen sonomorphologisch genauer zu charakterisieren, zu quantifizieren und als Verlaufsparameter zu untersuchen.

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“…3A), however, higher sensitivity has been reported with transoral MUS. 56 The diagnosis of ALS can be established if fasciculations (regarded as signs of the 2nd motor neuron) are present in two different body regions, and if additionally signs of the 1st motor neuron are present. 57 SMA (and ALS) can be discriminated from hereditary muscular disorder with high sensitivity and specificity, if fasciculations are present on MUS in at least two different muscles groups.…”

Section: Motor Neuron Diseasesmentioning

confidence: 99%

Muscle Ultrasound in Clinical Neurology: Diagnostic Uses and Guidance of Botulinum Toxin Injection

Walter¹

2023

J Neurosonol Neuroimag

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Muscle ultrasound (MUS) is increasingly used by neurologists, neuropediatricians, neurosurgeons, specialized radiologists and anaesthesiologists for the imaging-supported diagnosis of neuromuscular disorders. Especially, MUS is highly sensitive in detecting fasciculations in motor neuron diseases, and in revealing intensive care unit acquired weakness. Hereditary and inflammatory myopathies are associated with distinct patters of echo-intensity changes of affected muscles. Moreover, MUS can be used for guiding needle biopsy of muscle lesions, and for targeting intramuscular botulinum neurotoxin (BoNT) injection in neurological disorders with muscle hyperactivity. MUS-guidance of BoNT injection is especially recommendable in complex cervical dystonia, in task-related hand dystonia (writer’s cramp, musician dystonia), and in children and adolescents with cerebral palsy. Modern ultrasound technologies such as sono-elastography, tissue Doppler, and high-definition microvasculature imaging allow for novel diagnostic and therapeutic uses. Recently, an international expert group reported consensus guidelines for neuromuscular ultrasound training. The present review provides a concise overview of well-established diagnostic and therapeutic applications of MUS in clinical neurology, with specific focus at MUS for targeting intramuscular BoNT injections.

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Utility of transoral motion‐mode ultrasonography to detect tongue fasciculation in patients with amyotrophic lateral sclerosis

Cited by 6 publications

References 13 publications

Application of Ultrasonography in Neurogenic Dysphagia: A Systematic Review

Application of Ultrasonography in Neurogenic Dysphagia: A Systematic Review

Bedeutung der Muskelsonographie in der Detektion von Faszikulationen bei der ALS

Muscle Ultrasound in Clinical Neurology: Diagnostic Uses and Guidance of Botulinum Toxin Injection

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