Utility of tissue microarrays for profiling prognostic biomarkers in clinically localized prostate cancer: the expression of BCL-2, E-cadherin, Ki-67 and p53 as predictors of biochemical failure after radical prostatectomy with nested control for clinical and pathological risk factors

Expression of E-Cadherin, Cox-2, P53 and BCL-2 in Prostate Carcinomas: Correlation with Tumor Differentiation and Metastatic Potential

“…Although tumors with higher grade, higher stage and androgen-independent tumors show overexpression, its mechanism is not clearly explained yet (7,11,15). There are conflicting reports in the literature on the role of p53; some suggest that it has prognostic value (23), while others report no independent prognostic importance (20,34). In this study there was no statistically significant relation between p53 immunoreactivity and the degree of tumor differentiation or metastasis.…”

“…However, sometimes metastatic potential and prognosis is not related with PSA levels. Despite evaluation of numerous markers such as p53, Bcl-2, Ki-67 and e-cadherin, there is substantial variance between the findings of different studies (20). e-cadherin is an adhesion molecule which has an important role on normal cell growth and development.…”

“…in prostate carcinomas overexpression of bcl-2 has also been shown (20). overexpression of bcl-2 enhances growth of prostate carcinoma by helping tumor cells escape from apoptosis and augmenting angiogenesis (16).…”

Progress on Understanding the Anticancer Mechanisms of Medicinal Mushroom: Inonotus Obliquus

“…Hereafter, Zhong et al (2010) also found the decreased expression of Bcl-2 and increased expression of caspase-3 and Bax after co-culture of 80 mg /L I. obliquus extract with human gastric BGC2823 cell line for 48 h. However, beside the up-regulated expression of p53 and Bax proteins and the down-regulated Bcl-2 protein, the expression of Ki-67 whose synthesis and expression are closely related to cell proliferation (Nariculam et al, 2009) found to decreases with the increase of Inotodiol concentration and exposure time when A549 cells are arrested in S phase by Inotodiol (Zhong et al, 2011).…”

Small interfering RNA targeting HMGN5 induces apoptosis via modulation of a mitochondrial pathway and Bcl-2 family proteins in prostate cancer cells

“…24 Several high-throughput studies have confirmed that Bcl-2 is overexpressed in clinically localized prostate cancer compared with benign prostatic tissue. 25 Apoptosis is regulated through a diverse range of cellular signals. Overall, these signals can be divided into two pathways, namely, the extrinsic and the intrinsic apoptotic pathways.…”