Utility of the Spanish version of the FTLD-modified CDR in the diagnosis and staging in frontotemporal lobar degeneration

Russo, Griselda; Russo, María Julieta; Buyatti, Daniela; Chrem, Patricio; Bagnati, Pablo; Suárez, Marcos Fernández; Campos, Jorge; Cohen, Gabriela; Amengual, Alejandra; Allegri, Ricardo; Knopman, David S.

doi:10.1016/j.jns.2014.06.024

Cited by 17 publications

(31 citation statements)

References 19 publications

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“…After removing duplicates and irrelevant studies, 25 full‐text articles remained for further review of their eligibility. Of these, two studies did not adopt designated reference criteria, 37,38 and eight studies did not provide sufficient data to produce a 2 × 2 table even after contacting the original authors 39–46 . In total, 15 studies eventually satisfied the eligibility criteria.…”

Section: Resultsmentioning

confidence: 99%

Diagnostic accuracy of the Clinical Dementia Rating Scale for detecting mild cognitive impairment and dementia: A bivariate meta‐analysis

Huang

Tseng

Chen

et al. 2020

Int J Geriat Psychiatry

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ObjectiveThe Clinical Dementia Rating (CDR) Scale comprising global score (CDR‐GS) and sum of boxes scores (CDR‐SB) is commonly used in staging cognitive impairment; however, its diagnostic accuracy is not well clarified. The meta‐analysis aimed to investigate the diagnostic accuracy of the CDR for mild cognitive impairment (MCI) and dementia in older populations.MethodsStudies examining the diagnostic accuracy of the CDR for MCI or dementia against reference standards were included from seven electronic databases. The bivariate analysis with a random‐effects model was adopted to calculate the pooled sensitivity and specificity of the CDR for MCI and dementia.ResultsFifteen studies investigating the diagnostic accuracy of the CDR‐GS (n = 13) or CDR‐SB (n = 5) for MCI or dementia were included. The pooled sensitivity and specificity of the CDR‐GS for MCI were 93% and 97%, respectively. With respect to dementia, the CDR‐GS had superior pooled specificity compared to the CDR‐SB (99% vs. 94%), while similar sensitivities were found between the CDR‐GS and CDR‐SB (both 87%). Significant moderators of an old age, a high educational level, a high prevalence of MCI or dementia, being in a developing country, and a lack of informants' observations may affect the estimation of the sensitivity or specificity of the CDR.ConclusionsEvidence supports the CDR being useful for detecting MCI and dementia; applying the CDR for staging cognitive impairment in at risk populations should be considered. Furthermore, including objective observations from relevant informants or proxies to increase the accuracy of the CDR for dementia is suggested.

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Section: Resultsmentioning

confidence: 99%

Diagnostic accuracy of the Clinical Dementia Rating Scale for detecting mild cognitive impairment and dementia: A bivariate meta‐analysis

Huang

Tseng

Chen

et al. 2020

Int J Geriat Psychiatry

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“…LA bvFTD patients have impaired phonemic fluency relative to healthy controls ( 56 – 58 , 60 , 68 – 70 , 72 , 74 , 75 ). This has been observed for both Spanish-speaking ( 57 , 60 , 74 , 75 ) and Portuguese-speaking ( 68 , 72 ) cohorts, across different age groups (mean age varying from 64.4 to 70.2 years old) and education levels (years of education ranging from 10.8 to 16.0 years). Non-significant differences were reported by Torralva et al ( 62 ), although these results came from a smaller sample with higher MMSE scores than those reported in other studies.…”

Section: Linguistic Research In La Bvftdmentioning

confidence: 94%

“…Non-significant differences were reported by Torralva et al ( 62 ), although these results came from a smaller sample with higher MMSE scores than those reported in other studies. Also, phonemic fluency outcomes do not differ significantly between bvFTD and AD [( 58 , 68 , 72 , 73 ), but see ( 60 )]. Comparisons with PPA have yielded mixed results: while some studies report better performance for bvFTD than non-fluent variant PPA and semantic variant PPA patients ( 74 , 75 ), other found no significant difference between groups ( 60 , 69 , 70 ).…”

Section: Linguistic Research In La Bvftdmentioning

confidence: 99%

“…Also, phonemic fluency outcomes do not differ significantly between bvFTD and AD [( 58 , 68 , 72 , 73 ), but see ( 60 )]. Comparisons with PPA have yielded mixed results: while some studies report better performance for bvFTD than non-fluent variant PPA and semantic variant PPA patients ( 74 , 75 ), other found no significant difference between groups ( 60 , 69 , 70 ). 1 Phonemic fluency performance in LA bvFTD patients has been shown to correlate with the volume of core affected regions –e.g., the bilateral insula and putamen, the right amygdala, fusiform and inferior frontal gyri, and the left superior temporal and orbitofrontal cortices ( 57 ).…”

Section: Linguistic Research In La Bvftdmentioning

confidence: 99%

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Language in Behavioral Variant Frontotemporal Dementia: Another Stone to Be Turned in Latin America

et al. 2021

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Beyond canonical deficits in social cognition and interpersonal conduct, behavioral variant frontotemporal dementia (bvFTD) involves language difficulties in a substantial proportion of cases. However, since most evidence comes from high-income countries, the scope and relevance of language deficits in Latin American bvFTD samples remain poorly understood. As a first step toward reversing this scenario, we review studies reporting language measures in Latin American bvFTD cohorts relative to other groups. We identified 24 papers meeting systematic criteria, mainly targeting phonemic and semantic fluency, naming, semantic processing, and comprehension skills. The evidence shows widespread impairments in these domains, often related to overall cognitive disturbances. Some of these deficits may be as severe as in other diseases where they are more widely acknowledged, such as Alzheimer's disease. Considering the prevalence and informativeness of language deficits in bvFTD patients from other world regions, the need arises for more systematic research in Latin America, ideally spanning multiple domains, in diverse languages and dialects, with validated batteries. We outline key challenges and pathways of progress in this direction, laying the ground for a new regional research agenda on the disorder.

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“…Naming, as assessed using traditional tasks, is most frequently impaired in bvFTD patients. The most frequently used task was the Boston Naming Test (BNT), with 12 studies revealing impairments (Ash et al, 2016;Banks & Weintraub, 2008;Couto et al, 2013;De Winter et al, 2016b;Fernandez-Duque & Black, 2007;Lin et al, 2016;Peelle et al, 2008;Russo et al, 2014;Tan et al, 2015;Torralva et al, 2007;Whitwell et al, 2009;Wicklund et al, 2007) and six reporting preserved abilities (Chan et al, 2015;Gleichgerrcht et al, 2012;Kamminga et al, 2014;McKinnon et al, 2008;Rankin et al, 2007;Scherling et al, 2014).…”

Section: Word Retrievalmentioning

confidence: 99%

Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review

Géraudie

Battista

García

et al. 2021

Preprint

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Although behavioral variant frontotemporal dementia (bvFTD) is classically defined by behavioral and socio-emotional changes, impairments often extend to other cognitive functions. These include early speech and language deficits related to the disease’s core neural disruptions. Yet, their scope and clinical relevance remains poorly understood. This systematic review characterizes such disturbances in bvFTD, considering clinically, neuroanatomically, genetically, and neuropathologically defined subgroups. We included 181 experimental studies, with at least 5 bvFTD patients diagnosed using accepted criteria, comparing speech and language outcomes between bvFTD patients and healthy controls or between bvFTD subgroups. Results reveal extensive and heterogeneous deficits across cohorts, with (a) consistent lexico-semantic, orthographic, and prosodic impairments; (b) inconsistent deficits in motor speech and grammar; and (c) relative preservation of phonological skills. Also, preliminary findings suggest that the severity of speech and language deficits might be associated with global cognitive impairment, predominantly temporal or fronto-temporal atrophy and MAPT mutations (vs C9orf72). Although under-recognized, these impairments contribute to patient characterization and phenotyping, while potentially informing diagnosis and prognosis.

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Utility of the Spanish version of the FTLD-modified CDR in the diagnosis and staging in frontotemporal lobar degeneration

Cited by 17 publications

References 19 publications

Diagnostic accuracy of the Clinical Dementia Rating Scale for detecting mild cognitive impairment and dementia: A bivariate meta‐analysis

Diagnostic accuracy of the Clinical Dementia Rating Scale for detecting mild cognitive impairment and dementia: A bivariate meta‐analysis

Language in Behavioral Variant Frontotemporal Dementia: Another Stone to Be Turned in Latin America

Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review

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