Utility of the REM sleep behavior disorder screening questionnaire (RBDSQ) in Parkinson’s disease patients

Nomura, Takashi; Inoue, Yuichi; Kagimura, Tatsuo; Uemura, Yoshiko; Nakashima, Kenichiro

doi:10.1016/j.sleep.2011.01.015

Cited by 184 publications

(190 citation statements)

References 8 publications

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“…It is possible that patients with non-aggressive nocturnal behaviors receive less medical attention, which might lead to an underestimation of RBD frequency in women. Similar to other studies, we did not find any association with age Nomura et al 2011;Poryazova et al 2013). …”

Section: Discussionsupporting

confidence: 91%

Validation of the Beijing Version of the REM Sleep Behavior Disorder Questionnaire (RBDQ-Beijing) in a Mainland Chinese Cohort

Chang

Zhan

et al. 2014

Tohoku J. Exp. Med.

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REM sleep behavior disorder (RBD) is one type of parasomnia characterized by nocturnal complex motor activity associated with dream mentation. Growing evidence has indicated that RBD is a preclinical stage of neurodegenerative diseases. Therefore screening RBD patient is becoming important. The RBD Questionnaire-Hong Kong (RBDQ-HK) is an effective questionnaire to screen RBD patients. However, it is hard to distinguish RBD with the questionnaire from severe OSAS patients, who could mimic some symptoms of RBD patients. Therefore, we made RBDQ-Beijing by adding two screening questions for OSAS into original RBDQ-HK, including habitual loud snoring and witnessed apnea during sleep. To validate and compare these two questionnaires, 224 subjects were enrolled and screened with these questionnaires, and consequently analyzed with video-polysomnography. Receiver-operator characteristics curve analysis was conducted to attain the best cut-off values of the RBDQ-HK and RBDQ-Beijing. For the RBDQ-HK, the sensitivity was 97.1% and the specificity was 83.2%. More than half of misclassified RBD patients were proved to be severe OSAS patients. For the RBDQ-Beijing, the sensitivity was 95.8% and specificity was 94.3%, indicating that our questionnaire is able to distinguish RBD from severe OSAS patients. In conclusion, RBDQ-Beijing is of help to improve the specificity in RBD screening without excluding the patients with RBD combined OSAS. Therefore the RBDQ-Beijing may be a better screening and preliminary diagnostic tool for RBD than the RBDQ-HK. Moreover, the RBDQ-Beijing would be important for early diagnosis of neurodegenerative diseases and for prevention of injuries to the patient or the patient's bed partner.

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Section: Discussionsupporting

confidence: 91%

Validation of the Beijing Version of the REM Sleep Behavior Disorder Questionnaire (RBDQ-Beijing) in a Mainland Chinese Cohort

Chang

Zhan

et al. 2014

Tohoku J. Exp. Med.

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“…We used RBDSQ, recently validated in PD patients with a cutoff of 6 points, 20 to identify patients with probable RBD in a large sample of PD patients. Nearly 43% of our patients had a RBDSQ score ≥ 6, suggestive of RBD, which is higher than the frequency reported in most previous history-based studies and close to PSG-based studies.…”

Section: Discussionmentioning

confidence: 99%

“…Values > 6 points are considered suggestive for RBD. 20 The questionnaire also assessed PD characteristics, with 6 items gathering information on time of first symptoms, diagnosis and start of treatment, invasive treatment, and type of the PD.…”

Section: Methodsmentioning

confidence: 99%

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REM Sleep Behavior Disorder in Parkinson's Disease: A Questionnaire-Based Survey

Poryazova

Oberholzer

Baumann

et al. 2013

Journal of Clinical Sleep Medicine

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bRIEF SUMMaRYCurrent Knowledge/Study Rationale: RBD is very common in PD and there have been multiple attempts to fi nd a questionnaire based diagnostic tool for RBD. For the fi rst time we use a previously validated questionnaire tool assessment of RBD in a large, unselected sample of PD patients. Study Impact: RBD in PD could be detected by a validated questionnaire tool in 42.6% of the patients, which is comparable to the frequency found in PSG-based studies. It was associated with more advanced disease, sleep fragmentation and hallucinations.

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“…The Japanese version of the RBD screening questionnaire (RBDSQ-J) (25,26) was used to detect patients with probable RBD (pRBD). Patients with PD and an RBDSQ-J score of 6 or over were diagnosed with pRBD.…”

Section: Evaluation Of Motor and Non-motor Symptomsmentioning

confidence: 99%

Beneficial Effects of Ramelteon on Rapid Eye Movement Sleep Behavior Disorder Associated with Parkinson's Disease - Results of a Multicenter Open Trial

et al. 2016

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Objective Melatonin is effective for treating patients with rapid eye movement sleep behavior disorder (RBD). Ramelteon, a novel hypnotic, acts as a melatonin receptor agonist. In the current study, we investigated the effects of ramelteon on sleep disorders, including RBD, in patients with Parkinson's disease (PD). Methods We evaluated 35 patients from multiple centers with idiopathic PD accompanied by sleep disturbances (age: 69.1±11.1 years; 17 men, 18 women; PD morbidity: 6.9±5.7 years; Hoehn & Yahr stage: 2.5± 0.8; levodopa dose equivalent: 561±401 mg/day). The patients received 8 mg of ramelteon before sleep once daily for 12 weeks. Motor and sleep symptoms were evaluated both before and after ramelteon administration. Results Of the 35 patients enrolled in this study, 24 (68.6%) were diagnosed with probable RBD (pRBD) using the Japanese version of the RBD screening questionnaire. Ramelteon administration reduced the severity of sleep disturbances in patients with PD. It also lowered scores on the Japanese version of the RBD questionnaire in patients with PD and pRBD. Conclusion Ramelteon may have beneficial effects on sleep disturbances, especially on RBD in patients with PD.

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Utility of the REM sleep behavior disorder screening questionnaire (RBDSQ) in Parkinson’s disease patients

Cited by 184 publications

References 8 publications

Validation of the Beijing Version of the REM Sleep Behavior Disorder Questionnaire (RBDQ-Beijing) in a Mainland Chinese Cohort

Validation of the Beijing Version of the REM Sleep Behavior Disorder Questionnaire (RBDQ-Beijing) in a Mainland Chinese Cohort

REM Sleep Behavior Disorder in Parkinson's Disease: A Questionnaire-Based Survey

Beneficial Effects of Ramelteon on Rapid Eye Movement Sleep Behavior Disorder Associated with Parkinson's Disease - Results of a Multicenter Open Trial

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