Utility of the Least Squares Method in the PMR Spectrometric Assay of Chloramphenicol and Streptomycin with Their Degradation Products

Elsayed, M. Abdel-Hady; Korany, Mohamed A.; Habib, N. S.; Galal, Shereen M.

doi:10.1080/00387018908053875

Spectroscopy Letters

1989

DOI: 10.1080/00387018908053875

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Utility of the Least Squares Method in the PMR Spectrometric Assay of Chloramphenicol and Streptomycin with Their Degradation Products

M. Abdel-Hady Elsayed

Mohamed A. Korany

N. S. Habib

et al.

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Cited by 2 publications

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“…the products of levomycetin decomposition in commercial preparations [18][19][20][21][22][23][24][25][26][27][28]. The analyses were performed by methods of spectrophotometry [18,20], gas chromatography [21], HPLC [22,25,26], reverse-phase liquid chromatography [23,28], IH NMR spectroscopy [24], and liquid chromatography in combination with mass spectrometry [27].…”

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Levomycetin andthreo-2-amino-1-(4-nitrophenyl)-1,3-propanediol

1998

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Levomycetin, or D-(-)-threo-2-dichloroacetylamino-l-(4-nitrophenyl)-l,3-propanediol, has been used in medicine and veterinary for about 50 years. However, the development of new methods for the synthesis of this drug, the technological perfection of some stages involved in the process, the search for the possibility of using intermediate deacylated derivatives, and quality control of drug preparations are still drawing close attention of researchers. Below we summarize the data published in this field during 1983 -1995. Development of New Methods for the Synthesis of Levomycetin and Perfection of Separate Technological StagesProcesses patented during the past 15 years include acylation of the corresponding aminodiol by dichloroacetic acid methyl ester [1], simultaneous hydroxymethylation and reduction of 2-acetylarnino-2-(4-nitrophenyl)ethan-l-one [2], reduction of 2-acetylarrfino-3-hydroxy-l-(4-nitrophenyl)-1propanone [3,4], and the subsequent deacetylation of the reduced product [5,6], nitriding postponed to the latest stages of the process and nitriding of 5-acetylamino-4-phenyl-1,3dioxane [7], and separation of the enantiomer mixture of the corresponding aminodiols [8]. Of special interest was the study of possible stereochemical inversion of 1S,2S-threo-2amino-2-(4-nitrophenyl)-l,3-propanediol to its IR,1R-enantiomer [9, 10] and the use of asymmetric epoxidation of 3-(4nitrophenyl)-2-propen-1-ol followed by opening of the epoxide cycle [ 11 ]. Also noteworthy is the synthesis and use for investigation purposes of 3H-labeled [12, 13] and 35Cl-labeled [14] levomycetin and its fluorescent derivatives [15,16]. Analytical determination of Levomycetin and the Products of Its MetabolismPapers published during the past 15 years were devoted to determination of levomycetin and its metabolites [17] and 157

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Levomycetin andthreo-2-amino-1-(4-nitrophenyl)-1,3-propanediol

1998

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Current state and prospects of NMR spectroscopy application in pharmaceutical analysis (a review)

Kartashov

1996

Pharm Chem J

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Utility of the Least Squares Method in the PMR Spectrometric Assay of Chloramphenicol and Streptomycin with Their Degradation Products

Cited by 2 publications

References 9 publications

Levomycetin andthreo-2-amino-1-(4-nitrophenyl)-1,3-propanediol

Levomycetin andthreo-2-amino-1-(4-nitrophenyl)-1,3-propanediol

Current state and prospects of NMR spectroscopy application in pharmaceutical analysis (a review)

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