Utility of the Cervical Cytologic Smear in Assessing Endocervical Involvement by Endometrial Carcinoma

Liquid-based Papanicolaou test (SurePath) interpretations before histologic diagnosis of endometrial hyperplasias and carcinomas

“…Studies since 1970 have focused predominantly on the potential role of cervical cytology as a predictor of grade, stage, or other clinical parameters (Table 4). 3,18,[22][23][24][25][26][27][28][29][30][31][32][33][34] The sensitivities of those studies range from 20% to 90%. Many report higher sensitivity than we found in the current study; however, in most instances, this well may have resulted from a review of Pap tests by cytologists who were aware of the underlying malignancy, with a concomitant change in the perception of abnormal.…”

“…Many report higher sensitivity than we found in the current study; however, in most instances, this well may have resulted from a review of Pap tests by cytologists who were aware of the underlying malignancy, with a concomitant change in the perception of abnormal. 3,24,26,27,29,32 Comparisons between those studies also are hampered by significant differences in the classification of Pap tests, including a lack of consensus about whether benign-appearing endometrial cells constitute normal or abnormal findings. In addition, differentiating between benign, atypical, and malignant endometrial cells in Pap tests may be difficult.…”

Primitive Neuroectodermal Tumor of the Uterus

“…24 More commonly a carcinomatous lesion, such as poorly differentiated carcinoma of either the cervix or endometrium, would be expected rather than PNET in a smear. 42 These tumors are aggressive, with small, anaplastic cells with hyperchromatic nuclei, scant cytoplasm and finely to coarsely granular chromatin. 13,26 PNET cells are more diffuse and uniform in appearance.…”

Value of Cervical Cytology in Diagnosing Endometrial Carcinoma in Women with Postmenopausal Bleeding

“…In 25% of the malignancies, adenocarcinoma cells were present (Pap V), which is within the range of 15-50% reported in the literature. 9,10,12,13,[21][22][23][24][25][26] We compared the Pap classification and the CISOE-A classification. A hypothetical advantage of the CISOE-A classification is that women with abnormal sqaumous cells can be differentiated from women with other abnormal cells.…”