Utility of Stool Sample–based Tests for the Diagnosis of <i>Helicobacter pylori</i> Infection in Children

Leal, Yelda A.; Cedillo‐Rivera, Roberto; Simon, J.; Velázquez, Juan R.; Flores, Laura L; Torres, Javier

doi:10.1097/mpg.0b013e3182077d33

Cited by 71 publications

(58 citation statements)

References 96 publications

(155 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recent meta-analysis study on the HpSA test reported that the HpSA test using ELISA polyclonal antibodies had the sensitivity of 92 %, the specifi city of 93 %, LR+ of 16.2, and LR− of 0.09. The monoclonal study also revealed higher diagnostic accuracy in children with sensitivity of 97 %, specifi city of 97 %, LR+ of 29.9, and LR− of 0.03 [ 8 ]. Additionally, another recent meta-analysis in 2014 reported similar diagnostic accuracy of the EIA-based HpSA test in children, reporting an overall pooled sensitivity of 92.1 %, specifi city of 94.1 %, LR+ of 17.01, and LR− of 0.08 [ 9 ].…”

Section: Diagnostic Accuracy Of H Pylori Stool Antigen Test In Untrementioning

confidence: 88%

“…The test is very easy to perform and suitable as a one-step in-offi ce test because it takes only 5-15 minutes to interpret the test results grossly without any expensive equipment or skilled personnel. However, diagnostic accuracy of the rapid HpSA test is similar or a bit lower than the conventional HpSA test [ 16 ], with sensitivity of 88 %, specifi city of 93 %, LR+ of 10.6, and LR− of 0.11, according to a recent meta-analysis study [ 8 ]. Therefore, this rapid HpSA test has some limitations in clinical practice despite its convenience.…”

Section: H Pylori Stool Antigen Test Based On Immunochromatographymentioning

confidence: 95%

See 1 more Smart Citation

H. pylori Stool Antigen Test

Yang

2016

Helicobacter Pylori

View full text Add to dashboard Cite

Helicobacter pylori ( H. pylori ) stool antigen (HpSA) test is a reliable noninvasive diagnostic method for the detection of H. pylori infection in both adults and children. According to recent data, the HpSA test using an enzyme immunoassay is well validated as a noninvasive test to determine the status of H. pylori infection with high diagnostic accuracy before eradication therapy as well as after therapy. The HpSA test using a monoclonal antibody is more accurate than a polyclonal antibody test. The rapid HpSA test is also a reliable test and easy to perform in clinical practice. When the HpSA test is applied, some factors that can affect the diagnostic accuracy such as drugs, temperature, and gastrointestinal bleeding and diarrhea as accompanying symptoms should be taken into consideration to interpret the results of the HpSA test. Keywords

show abstract

Section: Diagnostic Accuracy Of H Pylori Stool Antigen Test In Untrementioning

confidence: 88%

Section: H Pylori Stool Antigen Test Based On Immunochromatographymentioning

confidence: 95%

H. pylori Stool Antigen Test

Yang

2016

Helicobacter Pylori

View full text Add to dashboard Cite

show abstract

“…According to a recent meta-analysis study on HpSA testing in children, diagnostic accuracy of ELISA monoclonal antibody revealed the best performance with pooled sensitivity of 97 %, specifi city 97 %, LR+ of 29.9, and LR-of 0.03 [ 28 ]. On the other hand, HpSA test using ELISA polyclonal antibody had relatively lower accuracy with a sensitivity of 92 %, specifi city of 93 %, LR+ of 16.2, and LR-of 0.09, with high heterogeneity [ 28 ].…”

Section: H Pylori Stool Antigen Test In Childrenmentioning

confidence: 96%

Specific Conditions: Children

Yang

2016

Helicobacter Pylori

View full text Add to dashboard Cite

Helicobacter pylori ( H. pylori ) infection is usually acquired during childhood, causing various diseases even in children. When applying diagnostic tests to children suspected of H. pylori infection, there are some differences between children and adults, although endoscopy with biopsies is also recommended for the initial diagnosis of H. pylori infection in children. On endoscopy, nodular gastritis is a pathognomonic gross fi nding of childhood H. pylori infection. On histopathology of gastric tissues, infi ltration of lymphocytes and plasma cells and formation of mucosa-associated lymphoid tissue are the prominent features in children. Noninvasive diagnostic methods are also available and well validated in children. Both the 13 C-urea breath test (UBT) and the H. pylori stool antigen test based on the enzyme immunoassay using monoclonal antibody are reliable in identifying H. pylori status before and after therapy. However, when applying UBT to children younger than 6 years, test results should be interpreted cautiously because they tend to have high false positives. Serologic tests or urine tests are not recommended in children because of low diagnostic accuracy.

show abstract

“…The systematic review and meta-analysis conducted by Leal et al [56] established that stool ELISA using monoclonal antibodies is an efficient noninvasive test for the diagnosis of H. pylori infection in children.…”

Section: Stool Antigen Testsmentioning

confidence: 99%

Epidemiology and Diagnosis of Helicobacter pylori Infection

et al. 2012

View full text Add to dashboard Cite

Medline, PubMed and the Cochrane databases were searched on epidemiology and diagnosis of Helicobacter pylori for the period of April 2011-March 2012. Several studies have shown that the prevalence of H. pylori infection is decreasing in adults and children in many countries. Various diagnostic tests are available, and most of them have high sensitivity and specificity. The Maastricht IV/Florence consensus report states that the urea breath test using 13 C urea remains the best test to diagnose H. pylori infection. Among the stool antigen tests, the ELISA monoclonal antibody test is recommended. All these tests were used, either as a single diagnostic test or in combination, to investigate H. pylori infection among different populations throughout the world. Of particular interest, current improvements in high-resolution endoscopic technologies enable increased diagnostic accuracy for the detection of H. pylori infection, but none of these techniques, at present, are specific enough for obtaining a real-time diagnosis of H. pylori infection.

show abstract

Utility of Stool Sample–based Tests for the Diagnosis of Helicobacter pylori Infection in Children

Cited by 71 publications

References 96 publications

H. pylori Stool Antigen Test

H. pylori Stool Antigen Test

Specific Conditions: Children

Epidemiology and Diagnosis of Helicobacter pylori Infection

Contact Info

Product

Resources

About