Utility of Semiquantitative Strain Elastography for Differentiation Between Benign and Malignant Solid Renal Masses

Onur, Mehmet Ruhi; Poyraz, Ahmet Kursad; Bozgeyik, Zülkif; Onur, Ahmet Rahmi; Orhan, İsrafil

doi:10.7863/ultra.34.4.639

Cited by 36 publications

(34 citation statements)

References 24 publications

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“…[4,15,16] Strain elastography is based on the principle that compression produces strain within the tissue and the amount of strain is lower in stiffer tissue than in softer. [17] Since carcinomas were found to be stiffer than adjacent normal tissues and studies reported that histologically different tumors may display different elasticity patterns according to tissue architecture, [7,10] this technique has been successfully applied to differentiate focal lesions of testis, breast, prostate, pancreas and liver. [14,[18][19][20] Recently, shear wave elastography (SWE) which combines B-mode image with color-coded US generating a quantitative image SWE (kPa) of the tissue stiffness started to be used to exhibit different hardness among different tissue regions in real-time conditions.…”

Section: Discussionmentioning

confidence: 99%

“…[6] As a semiquantitative elastographic technique, SE compares the elasticity and stiffness of target tissues with nearby normal ones. [7] Basic assumption of SE is that soft tissues can be more deformable than hard ones which can be displayed on US as a colour map overlaid to the grey scale image. [8] The resultant strain ratio (SR) represents the ratio of stiffness of the target and normal tissues.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the diagnostic efficacy of strain elastography in infertile population with normal and abnormal semen parameters

Küçükdurmaz

Sarıca

Emre

et al. 2017

Turkish Journal of Urology

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Objective: The aim of the present study was to investigate the diagnostic value of strain elastography (SE) of testicular tissues in infertile population. We also evaluated the correlation between SE results with semen parameters and hormone profiles of the patients. Material and methods:A total of 61 patients and 122 testes were evaluated. Patients who were evaluated in an andrology outpatient clinic with the diagnosis of infertility and referred to radiology department for investigation of reproductive organs between June 2015 and January 2016 were included. Patients were divided into two groups according to semen analyses results as normal (Group 1) and abnormal (Group 2). Hormone profiles, semen analyses, B-mode, coloured Doppler ultrasonography and sonoelastography examinations were performed for each patient. Measurements of testicular volumes, resistive indices (RI) in intraparenchymal arteries, strain, strain ratio (SR) and presence of varicocele were recorded.Results: Mean age of participants was 33.7±6.3 years. Mean testicular volumes (Group 1, 19.41±4.8 mL, and Group 2, 17.64±3.62 mL) were significantly different between groups (p= 0.023). Mean SRs were also different between Groups 1 and 2 (0.12±0.08 vs. 0.22±0.18, p<0.001). Testicular volumes were directly proportional with SRs in Group 1. Strain values had inverse relationship with sperm concentration and total motile sperm counts in Group 2 (p= 0.01). SRs were found to be positively correlated with RI and sperm morphology in Group 2 (p<0.05). Although FSH values showed significant difference among groups, any correlation between FSH and elastographic parameters could not be displayed. Conclusion:Strain elastography results were found to be significantly different in patients with abnormal sperm counts. This technique may provide promising results, however, further large scale studies may help to clarify the value of this imaging modality in the assessment of male infertility.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of the diagnostic efficacy of strain elastography in infertile population with normal and abnormal semen parameters

Küçükdurmaz

Sarıca

Emre

et al. 2017

Turkish Journal of Urology

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“…Thus, it is a more useful method for investigating the elasticity of visceral organs. Few studies have evaluated the elasticity of renal tumors [21][22][23][24][25]. To the best of our knowledge, there are only five such reports in the English language literature (two regarding strain elastography and three regarding ARFI elastography).…”

Section: Discussionmentioning

confidence: 99%

“…Onur et al [21] used strain elastography to assess solid renal tumors, and found that benign masses had a lower mean strain index values than malignant ones (p<0.0001); malignant tumors were 2.8 times stiffer than benign tumors. Elasticity significantly differs between normal and neoplastic tissues.…”

Section: Discussionmentioning

confidence: 99%

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Value of Shear Wave Elastography for differentiating benign and malignant renal lesions

et al. 2018

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Aims: To investigate the diagnostic accuracy of shear-wave elastography (SWE) for assessing malignant and benign kidneymasses.Materials and methods: Forty patients with solid renal masses underwent US elastographic evaluation. SWE values of the lesions and adjacent cortical renal parenchyma and SWER were detected prospectively. Malignant tumors were recorded as group 1 and benign tumors were recorded as group 2.Results: The highest elasticity values were 27.27±25.66 kPa for group 1 and 16.13±8.89 kPa for group 2. The mean±SD elasticity values for adjacent renal cortex for groups 1 and 2 were 2.7±2.08 and 2.75±1.35, respectively. For group 1, a negative correlation was observed between the age of the patients and SWER value (p=0.047, rs=‑0.401). There was also a negative correlation between the SWER value and the SWE value of adjacent renal cortex (p=0.004, rs=‑0.555).Conclusion: SWE is a noninvasive method that provides quantitative elasticity informationon tissues. Overlaps among different types of renal lesions may be due to heterogeneity of the lesions. Larger studygroups may clarify the other factors affecting SWE values under both normal and pathological conditions.

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Are There Ultrasound Features to Distinguish Small (<3 cm) Peripheral Renal Angiomyolipomas From Renal Cell Carcinomas?

Chen

McGahan

Wilson

et al. 2023

J of Ultrasound Medicine

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BackgroundSmall echogenic renal masses are usually angiomyolipomas (AMLs), but some renal cell carcinomas (RCCs) can be echogenic and confused with an AML.ObjectivesThis is a study to evaluate any distinguishing demographic and sonographic features of small (<3 cm) peripheral AMLs versus peripheral RCCs.MethodsThis is a HIPAA‐compliant retrospective review of the demographics and ultrasound features of peripheral renal AMLs compared with a group of peripheral RCCs. All AMLs had confirmation of macroscopic fat as noted on thin‐cut CT or fat‐saturation MRI sequence images. All RCCs were pathologically proven. Statistical analysis was used to compare findings in the two groups.ResultsThere were a total of 52 patients with 56 AMLs, compared with 42 patients with 42 RCCs. There were 42 females in the AML group versus 10 females in the RCC group (P < .0001). The AML diameters (15.7 mm × 12.0 mm) were statistically significantly smaller (Plargest = .0085, Psmallest < .001) than the diameters of the RCCs (19.9 mm × 18.5 mm). Ultrasound features found to be statistically different between the two groups were the ratio of the largest dimension to the smallest dimension (P < .001), a lobulated versus smooth margin of the AML (26 vs 30) compared with the RCC group (3 vs 39) (P = .0012), and an “unusual” versus a round shape (P < .001) of the AML group (45 vs 11) compared with the RCC group (9 vs 33). In the multivariable model, the patient sex, margin, and mass shape were predictive of AML, with an area under the receiver operating characteristic curve of 0.92.ConclusionFor a small (<3 cm) peripheral echogenic mass in a female patient, a lobulated lesion with an unusual shape is highly predictive of being an AML.

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Utility of Semiquantitative Strain Elastography for Differentiation Between Benign and Malignant Solid Renal Masses

Abstract: Strain elastography may be a useful imaging technique for differentiation between benign and malignant solid renal masses.

Cited by 36 publications

References 24 publications

Evaluation of the diagnostic efficacy of strain elastography in infertile population with normal and abnormal semen parameters

Evaluation of the diagnostic efficacy of strain elastography in infertile population with normal and abnormal semen parameters

Value of Shear Wave Elastography for differentiating benign and malignant renal lesions

Are There Ultrasound Features to Distinguish Small (<3 cm) Peripheral Renal Angiomyolipomas From Renal Cell Carcinomas?

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