Utility of routine laboratory testing in management of chronic urticaria/angioedema

Tarbox, James; Gutta, Ravi; Radojicic, Cristine; Lang, David M.

doi:10.1016/j.anai.2011.06.008

Cited by 37 publications

(10 citation statements)

References 14 publications

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“…Of 285 patients treated with thyroid medication, CSU was improved in 120 (42%) patients. Fourteen studies reported complete remission of CSU in 68 patients (24%) and partial improvement in 28 patients (10%) . Beneficial effects were not specified in 24 (8%) of 285 patients in two studies and were not seen in six studies in all patients.…”

Section: Resultsmentioning

confidence: 98%

Comorbidity of chronic spontaneous urticaria and autoimmune thyroid diseases: A systematic review

Kolkhir

Metz

Altrichter

et al. 2017

Allergy

144

118

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Patients with chronic spontaneous urticaria (CSU) are widely held to often have other autoimmune disorders, including autoimmune thyroid disease. Here, we systematically evaluated the literature on the prevalence of thyroid autoimmunity in CSU and vice versa. There is a strong link between CSU and elevated levels of IgG antithyroid autoantibodies (AAbs), with most of a large number of studies reporting rates of ≥10%. Levels of IgG against thyroid peroxidase (TPO) are more often elevated in CSU than those of other IgG antithyroid AAbs (strong evidence). Levels of IgG antithyroid AAbs are more often elevated in adult patients with CSU than in children (strong evidence). Patients with CSU exhibit significantly higher levels of IgG antithyroid AAbs (strong evidence) and IgE-anti-TPO (weak evidence) than controls. Elevated IgG antithyroid AAbs in CSU are linked to the use of glucocorticoids (weak evidence) but not to disease duration or severity/activity, gender, age, or ASST response (inconsistent evidence). Thyroid dysfunction rates are increased in patients with CSU (strong evidence). Hypothyroidism and Hashimoto's thyroiditis are more common than hyperthyroidism and Graves' disease (strong evidence). Thyroid dysfunction is more common in adult patients with CSU than in children (strong evidence) and in female than in male patients with CSU (weak evidence). Urticaria including CSU is more prevalent in patients with thyroid autoimmunity than in controls (weak evidence). CSU can improve in response to treatment with levothyroxine or other thyroid drugs (strong evidence). Pathogenic mechanisms in CSU patients with thyroid autoimmunity may include IgE against autoantigens, immune complexes, and complement.

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Section: Resultsmentioning

confidence: 98%

Comorbidity of chronic spontaneous urticaria and autoimmune thyroid diseases: A systematic review

Kolkhir

Metz

Altrichter

et al. 2017

Allergy

144

118

View full text Add to dashboard Cite

show abstract

“…In another recent study, Tarbox et al evaluated the utility of routine laboratory testing in CIU and concluded that such testing rarely leads to changes in management or better overall outcomes. [29] While this study was well powered with 356 patients, most of the patients had very mild disease as only 61 patients (17%) were taking medications other than antihistamines with or without LTRA. There was no indication of whether the patients were controlled on their medication regimen.…”

Section: Discussionmentioning

confidence: 99%

The role of autoimmune testing in chronic idiopathic urticaria

Viswanathan

Biagtan

Mathur

2012

Annals of Allergy, Asthma & Immunology

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“…52 Evidence suggests that laboratory testing can be postponed or deferred in most patients with chronic spontaneous urticaria. 53,54 Patients with refractory urticaria could be considered for telehealth or a face-to-face visit to recommend further evaluation and management, including initiation of omalizumab in properly selected patients. 55…”

Section: Communication With Patientsmentioning

confidence: 99%

COVID-19: Pandemic Contingency Planning for the Allergy and Immunology Clinic

Shaker

Oppenheimer

Grayson

et al. 2020

The Journal of Allergy and Clinical Immunology: In Practice

285

427

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

show abstract

Utility of routine laboratory testing in management of chronic urticaria/angioedema

Cited by 37 publications

References 14 publications

Comorbidity of chronic spontaneous urticaria and autoimmune thyroid diseases: A systematic review

Comorbidity of chronic spontaneous urticaria and autoimmune thyroid diseases: A systematic review

The role of autoimmune testing in chronic idiopathic urticaria

COVID-19: Pandemic Contingency Planning for the Allergy and Immunology Clinic

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