Utility of R2* Obtained from T2*-Weighted Imaging in Differentiating Hepatocellular Carcinomas from Cavernous Hemangiomas of the Liver

Abstract

PurposeTo evaluate the feasibility of applying R2* values to differentiate hepatocellular carcinomas (HCC) from cavernous hemangiomas of the liver (CHL).Materials and MethodsThis retrospective study was approved by the participating Institutional Review Board and written informed consent for all subjects were obtained. Seventy-three patients with 79 pathologically identified HCCs and 65 patients with 91 clinically or pathologically identified CHLs were enrolled in this study. All subjects underwent a breath-hold multi-echo T2* weighted MR imaging on a 1.5T clinical MR scanner. R2* values from HCC and CHL groups were compared using the Mann-Whitney non-parametric U test. A cut-off value of R2* was evaluated with receiver operator characteristic (ROC) analysis.ResultsThe mean R2* value was 23.32±12.23 Hz (95% confidence interval [CI]: 20.58 Hz, 26.06 Hz) for the HCC group, and 3.66±2.37 Hz (95% CI: 3.17 Hz, 4.15 Hz) for the CHL group. The mean R2* value for HCC was significantly higher than that of CHL (p<0.001). A threshold of 9.48 Hz for the minimum R2* value in the diagnosis of HCC resulted in a sensitivity of 96.20% (76 out of 79 patients), and a specificity of 97.80% (89 out of 91 patients). The positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy for HCC were 97.44% (76 out of 78 patients), 96.74% (89 out of 92 patients) and 97.06% (165 out of 170 patients), respectively. The AUC for differentiation between these two groups was 0.994 (95% CI: 0.980, 1.000).ConclusionsR2* is a significant MRI biomarker to differentiate HCC from CHL with satisfying sensitivity and specificity.

Value of R2* obtained from T2*‐weighted imaging in predicting the prognosis of advanced cervical squamous carcinoma treated with concurrent chemoradiotherapy

“…In contrast, in the nonresponder group tumor hypoxia might increase, which results in the higher deoxyhaemoglobin concentration and thus R2* value increases. 26 The area under the ROC of R2* was 0.769. The sensitivity was 78.3%, and specificity was 67.6% when the cutoff value was set as 28.37 Hz, which implicates that R2* might be helpful for discriminating responders from nonresponders.…”

“…The possible reason is that the responder group might have good tumor oxygenation, which results in lower deoxyhaemoglobin concentration and thus R2* value decreases. In contrast, in the nonresponder group tumor hypoxia might increase, which results in the higher deoxyhaemoglobin concentration and thus R2* value increases . The area under the ROC of R2* was 0.769.…”

The Application Value of MRI T 2 ∗ WI Radiomics Nomogram in Discriminating Hepatocellular Carcinoma from Intrahepatic Cholangiocarcinoma

“…Sun et al [26] reported that magnetic resonance blood oxygen level parameters R2 * and T2 * and their associated measurements were correlated with the clinical and 7 Computational and Mathematical Methods in Medicine pathological features of HCC. Zhang et al [27] investigated the significance of mean platelet volume (MPV) in discriminating HCC from ICCA and found that MPV correlation discrimination had the AUC, sensitivity, and specificity of 0.698, 80.2%, and 54.1%, respectively.…”

The biocompatibility evaluation of iron oxide nanoparticles synthesized by a one pot process for intravenous iron supply

“…23 In the process of IONs modication, SC is employed as stabilizer in the aer-treatment of IONs obtained by hydrothermal method, thermal decomposition method and co-precipitation method. 24,25 Polyethylenimine (PEI) coated IONs were synthesized through co-precipitation and modied by SC and PEI, which was used in the absorption for hexavalent chromium. 26 This work provided a simple and one pot method for synthesizing IONs with different sizes by adding different concentrations of SC.…”