Utility of procalcitonin for diagnosis of bacterial infection-related systemic inflammatory response in the acute neurologic injury population

Corry, Jesse J.; Ho, Bridget M; Marino, Emily H; Gupta, Aditi; Ravichandran, Jaya; Sperl, Michael A.; Tipps, Megan E.

doi:10.1016/j.clineuro.2019.105534

Cited by 1 publication

(1 citation statement)

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“…[7][8][9][10] As a widely used diagnostic marker of severe infection and sepsis, procalcitonin (PCT) has been confirmed to be associated with mortality in many clinical settings, such as sepsis, cancer, and trauma. [11][12][13][14][15][16][17] Moreover, the prognostic value of serum PCT in patients with neurological diseases including subarachnoid hemorrhage, ischemic stroke, intracerebral hemorrhage and epilepticus status have been explored. [18][19][20][21][22] Although several researchers have illustrated the prognostic value of PCT in TBI patients, the sample size of these studies were relatively small and included subjects were not limited to homogenous moderate-to-severe TBI patients.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of Serum Procalcitonin Based Model in Moderate to Severe Traumatic Brain Injury Patients

Wang¹,

Hua²,

He³

et al. 2022

JIR

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Objective Procalcitonin (PCT) is an acknowledged marker of systemic inflammatory response. Previous studies have not reached agreement on the association between serum PCT and outcome of traumatic brain injury (TBI) patients. We designed this study to confirm the prognostic value of PCT in isolated TBI and those with extracranial injury, respectively. Methods Patients hospitalized in our hospital for moderate-to-severe TBI between March 2015 and December 2019 were included. Logistic regression analysis was performed to validate the association between PCT and in-hospital mortality in these patients. AUC (area under the receiver operating characteristics curve) of PCT and constructed model were calculated and compared. Results Among the included 211 patients, 81 patients suffered a poor outcome, with a mortality rate of 38.4%. Non-survivors had a higher level of serum PCT (2.73 vs 0.72, p <0.001) and lower GCS (5 vs 7, p <0.001) on admission than survivors. AUC of single PCT for predicting mortality in isolated TBI and those with extracranial injury were 0.767 and 0.553, respectively. Multivariate logistic regression showed that GCS (OR=0.744, p =0.008), glucose (OR=1.236, p <0.001), cholesterol (OR=0.526, p =0.002), and PCT (OR=1.107, p =0.022) were independently associated with mortality of isolated TBI. The AUC of the prognostic model composed of GCS, glucose, cholesterol, and PCT was 0.868 in isolated TBI. Conclusion PCT is an efficient marker of outcome in isolated moderate-to-severe TBI but not those with extracranial injury. A prognostic model incorporating PCT is useful for clinicians to make early risk stratification for isolated TBI.

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