Utility of polygenic scores across diverse diseases in a hospital cohort for predictive modeling
Ting-Hsuan Sun,
Chia-Chun Wang,
Ting-Yuan Liu
et al.
Abstract:Polygenic scores estimate genetic susceptibility to diseases. We systematically calculated polygenic scores across 457 phenotypes using genotyping array data from China Medical University Hospital. Logistic regression models assessed polygenic scores’ ability to predict disease traits. The polygenic score model with the highest accuracy, based on maximal area under the receiver operating characteristic curve (AUC), is provided on the GeneAnaBase website of the hospital. Our findings indicate 49 phenotypes with… Show more
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