Utility of platelet rich fibrin gel therapy in nonhealing ulcer secondary to ecthyma gangrenosum

Abstract

Platelet rich fibrin (PRF) gel is a new second generation platelet concentrate, which has been widely used in various dermatological conditions such as nonhealing diabetic foot ulcers, venous ulcers, and trophic ulcers in leprosy. In this case report, we present a patient with nonhealing ulcer secondary to ecthyma gangrenosum, who showed dramatic response with PRF gel. This case suggests a role of PRF gel in nonhealing ulcers of infectious etiology which has not been described in English language literature. Considering previous literature and our case, it may be concluded that PRF gel may be utilized as an effective alternative for nonhealing ulcers of nonneoplastic etiology.

Autologous platelet‐rich fibrin injections in the management of facial cutaneous sinus tracts secondary to medication‐related osteonecrosis of the jaw

“…APCs were recently used in the treatment of posttraumatic scars and in the therapy of nonhealing ulcers with positive results 13,14 . Furthermore, PRF has been used in the surgical treatment of MRONJ with positive results in terms of mucosal healing and improvement of life's quality 15 .…”

“…Further studies will be needed to determine if PRF is a valid aid in dermatology and if it can be considered an alternative or support to other therapies, such as the use of specific drugs or phototherapy 13,14,17 …”