Utility of platelet indices in diagnosing the underlying cause of thrombocytopenia due to accelerated platelet destruction

Yalavarthi, Sushma; Halder, Nirvana Rasaily; Aparna, Pagidikalava

doi:10.21276/apalm.1717

Cited by 9 publications

(17 citation statements)

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“…P-LCR was observed to be significantly lower in cases than that of control group of our study which was in accordance to Babu et al [18] study finding of inverse relation between PLT and P-LCR. Conditions with thrombocytosis show lower P-LCR and those with thrombocytopenia show higher P-LCR [18,19].…”

Section: Original Research Articlementioning

confidence: 99%

Study of platelet parameters in bacterial infections of lower respiratory tract

Srujana

Yalavarthi

2018

Trop J Pathol Microbiol

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Background:Respiratory tract infections are one of the commonest bacterial infections. Platelets play an important role in inflammatory response against infectious agents. Bacterial components activate platelets to release inflammatory mediators. The changes platelets undergo during their activation are reflected in the platelet parameters. This study aims to evaluate platelet parameters in the lower respiratory tract infections. Materials & methods: Cross-sectional study on sputum culture proven bacterial infections of the lower respiratory tract was done for three months. Platelet parameters of 94 cases were compared with 94 healthy controls. Cases were sub grouped as group A (with leucocytosis) and group B (without leukocytosis). Comparative analysis of platelet parameters between these subgroups and controls was done. P value was calculated and <0.05 was considered significant. Results: Platelet count (p <0.05) and plateletcrit were higher, Mean platelet volume (p <0.05), Platelet distribution width (p <0.001) and Platelet large cell ratio were lower in cases compared to controls. Group A showed significantly higher PLT (p < 0.05) and PCT (p <0.001) than group B whereas the difference in other parameters was not significant. All platelet parameters were significantly altered in patients with leukocytosis on comparison with controls whereas only MPV, PDW and P-LCR showed significant change in patients without leukocytosis when compared with controls. Conclusion: Platelet parameters show variation in the lower respiratory tract infections. As they can be determined as a part of routine complete blood picture analysis, they may be considered as markers of inflammation in the diagnosis of lower respiratory tract infections.

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Section: Original Research Articlementioning

confidence: 99%

Study of platelet parameters in bacterial infections of lower respiratory tract

Srujana

Yalavarthi

2018

Trop J Pathol Microbiol

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“…Platelet indices include mean platelet volume (MPV), platelet distribution width (PDW) and platelet large cell ratio (PLCR). 2 , 6 The proposed normal value of MPV is 7.2 to 11.7 fL. 6 in immune thrombocytopenia, when the platelets gets destroyed in the spleen, the new platelets that are being formed in the bone marrow are larger ones than the normal and thus the MPV increases in immune thrombocytopenia.…”

Section: Introductionmentioning

confidence: 99%

“…2 , 6 The proposed normal value of MPV is 7.2 to 11.7 fL. 6 in immune thrombocytopenia, when the platelets gets destroyed in the spleen, the new platelets that are being formed in the bone marrow are larger ones than the normal and thus the MPV increases in immune thrombocytopenia. 6 The value of PDW ranges from 8.3% to 56.6% in healthy individual.…”

Section: Introductionmentioning

confidence: 99%

“… 6 The value of PDW ranges from 8.3% to 56.6% in healthy individual. 6 It is the measure of variability in size of platelets. 6 The changes in the PDW and MPV are always in the same direction, that is, if MPV increases, PDW also increases and vice versa.…”

Section: Introductionmentioning

confidence: 99%

“… 6 It is the measure of variability in size of platelets. 6 The changes in the PDW and MPV are always in the same direction, that is, if MPV increases, PDW also increases and vice versa. 6 PLCR tells about the percentage of the larger platelets in circulation.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic importance of mean platelet volume, platelet distribution width and platelet large cell ratio as screening tool in immune thrombocytopenia

Khan

Ullah

2020

Porto Biomedical Journal

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Objective: To determine diagnostic importance of mean platelet volume (MPV), platelet distribution width (PDW) and platelet large cell ratio (PLCR) in diagnosing cases of immune thrombocytopenia. Methodology: The study was done in Khyber Teaching hospital from January 2017 to May 2018. Cases with low platelet count of all the ages and both the genders were included in the study by non probability purposive sampling technique and were subjected to bone marrow aspiration to rule out other causes of thrombocytopenia and thus confirm the diagnosis of immune thrombocytopenia. The platelet indices were noted and their sensitivity, specificity and accuracy were determined for immune thrombocytopenia. Mean and standard deviation were used for quantitative data. Percentage and frequency were used to measure qualitative data. Data was analysed by SPSS. Results: 84 cases with thrombocytopenia of mean age 23.4 ± 12.1 years (range 7–81 years) were included in the study. There were 38 (45.2%) males and 46 (54.8%) females. There were 40 cases of immune thrombocytopenia. The sensitivity and specificity for PDW (59.1% and 43.1%, respectively), MPV (59.1% and 52.9%, respectively), and PLCR (50% and 52.9%, respectively) were found low to be used as screening tool for immune thrombocytopenia. Conclusion: The MPV, PDW and PLCR has low sensitivity and specificity and therefore should not be used as reliable screening tool in giving preliminary diagnosis of the immune thrombocytopenia.

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Mean platelet volume and mean platelet volume to platelet count ratio as predictors of severity and mortality in sepsis

Páez

Légua

Páez³

et al. 2022

PLoS ONE

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Introduction Sepsis is a public health problem due to its high prevalence and mortality. Mean platelet volume (MPV), a biomarker reported in routine blood counts, has been investigated and shows promise for determining fatal outcomes in septic patients. Objective Evaluate whether the mean platelet volume (MPV) and mean platelet volume-to-platelet count (MPV/P) ratio are predictors of clinical severity and mortality in patients with sepsis. Methods A prospective population cohort of 163 patients aged 18–97 years was recruited at the Intensive Care Unit of Pablo Arturo Hospital, Quito, Ecuador from 2017–2019 and followed up for 28 days. Patients were diagnosed with sepsis based on SEPSIS-3 septic shock criteria; in which the MPV and the MPV/P ratio were measured on days 1, 2, and 3. Sequential organ failure assessment (SOFA) score and presence of septic shock assessed clinical severity. Mortality on day 28 was considered the fatal outcome. Results The average age of the patients was 61,15 years (SD 20,94) and female sex was predominant. MPV cutoff points at days 1, 2 and 3 were >9,45fL, >8,95fL and >8, 85fL; and (MPV/P) ratio >8, 18, >4, 12 y >3, 95, respectively. MPV at days 2 (9,85fL) and 3 (8,55fL) and (MPV/P) ratio at days 1 (4,42), 2 (4,21), and 3 (8,55), were predictors of clinical severity assessed by septic shock, which reached significance in the ROC curves. MPV and (MPV/P) ratio were also predictors of clinical severity determined by SOFA at days 1, 2, and 3, where higher values were observed in non-survivors reaching significance in all categories. MPV and MPV/P ratio at days 1, 2 and 3 were independent predictor factors of mortality using Cox proportional hazards model (HR 2,31; 95% CI 1,36–3,94), (HR 2,11; 95% CI 1,17–3,82), (HR 2,13; 95% CI 1,07–4,21) and (HR 2,38; 95% CI 1,38–4,12), (HR 2,15; 95% CI 1,14–4,06), (HR 4,43; 95% CI, 1,72–11,37) respectively. Conclusions MPV and the MPV/P ratio are predictors of clinical severity and mortality in sepsis. The MPV and its coefficient are indicators of the biological behavior of platelets in sepsis. They should be considered as a cost-effective and rapidly available tool that guides the treatment.

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Utility of platelet indices in diagnosing the underlying cause of thrombocytopenia due to accelerated platelet destruction

Cited by 9 publications

References 0 publications

Study of platelet parameters in bacterial infections of lower respiratory tract

Study of platelet parameters in bacterial infections of lower respiratory tract

Diagnostic importance of mean platelet volume, platelet distribution width and platelet large cell ratio as screening tool in immune thrombocytopenia

Mean platelet volume and mean platelet volume to platelet count ratio as predictors of severity and mortality in sepsis

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