Utility of PET in Breast Cancer

Avril, Norbert; Schelling, M.; Dose, J.; Weber, Wolfgang; Schwaiger, Markus

doi:10.1016/s1095-0397(99)00032-1

Cited by 46 publications

(16 citation statements)

References 47 publications

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“…In the planning of surgical therapy, differentiation of unifocal from multifocal and multicentric lesions is indispensable as it influences the decision on whether to surgically ablate the breast or perform breast-preserving surgery: although unifocal and multifocal lesions may be treated with excision, multicentric breast cancers require mamma ablation. Avril et al reported that only 50% of multicentric or multifocal breast cancer sites were correctly identified by PET alone (36). In the current study, combined 18 F-FDG PET/CT offered correct classification in 84% of cases.…”

Section: Discussionsupporting

confidence: 46%

Breast Cancer Staging in a Single Session: Whole-Body PET/CT Mammography

Heusner¹,

Küemmel²,

Umutlu³

et al. 2008

J Nucl Med

103

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Section: Discussionsupporting

confidence: 46%

Breast Cancer Staging in a Single Session: Whole-Body PET/CT Mammography

Heusner¹,

Küemmel²,

Umutlu³

et al. 2008

J Nucl Med

103

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“…However, 18 F-FDG PET could be indicated for preoperative staging and primary diagnosis (17,18,(20)(21)(22)(23)(24). Breast cancer detection is still principally based on mammography, which misses about 10% of breast carcinomas (25)(26)(27)(28) because of dense breast tissue.…”

Section: Discussionmentioning

confidence: 99%

Improving Specificity of Breast MRI Using Prone PET and Fused MRI and PET 3D Volume Datasets

Moy

Ponzo²,

Noz³

et al. 2007

Journal of Nuclear Medicine

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MRI is a sensitive method for detecting invasive breast cancer, but it lacks specificity. To examine the effect of combining PET with MRI on breast lesion characterization, a prototype positioning device was fabricated to allow PET scans to be acquired in the same position as MRI scans-that is, prone. Methods: To test the hypothesis that fusion of 18 F-FDG PET and MRI scans improves detection of breast cancer, 23 patients with suspected recurrent or new breast cancer underwent a routine whole-body PET scan, a prone PET scan of the chest, and a routine breast MRI scan. The attenuation-corrected prone PET and MRI datasets were registered twice by different operators. The fusion results were judged for quality by visual inspection and statistical analysis. A joint reading of the MRI and PET scans side by side and integrated images was performed by a nuclear medicine physician and a radiologist. Sensitivity and specificity of MRI and combined MRI and PET scans were calculated on the basis of pathology reports or at least 1 y of clinical and radiologic follow-up. Results: All fusions were verified to be well matched using specific anatomic criteria. A total of 45 lesions was assessed. Lesion size range was 0.6 to 10.0 cm. Of the 44 breasts examined, 29 were suspicious for cancer, of which 15 were found to be positive on surgical excision. In lesion-by-lesion analysis, sensitivity and specificity of MRI alone were 92% and 52%, respectively; after MRI and PET fusion, they were 63% and 95%, respectively. The positive predictive value and the negative predictive value for MRI alone were 69% and 85%, respectively; after MRI and PET fusion, they were 94% and 69%, respectively. Conclusion: Acquisition of prone PET scans using the new positioning device permitted acquisition of prone scans suitable for fusion with breast MRI scans. Fused PET and MRI scans increased the specificity of MRI but decreased the sensitivity in this small group of patients. Additional data are needed to confirm the statistical significance of these preliminary findings.

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“…PET imaging has been reported to provide a low sensitivity to detect small breast cancers, but an increase in metabolic activity with tumor growth [9,12,13]. However, SUVmax of breast cancer with similar small size was also variable [4,[14][15][16][17][18], and small sized breast cancer might have high SUVmax. Similarly, Ueda et al [9] reported no significant relationship between tumor size and SUVmax, especially in lesions of 2 cm or less.…”

Section: Discussionmentioning

confidence: 99%

“…In the clinical setting, the intensity of 18 F-FDG uptake of breast cancer with similar tumor size was diverse [4,[14][15][16][17][18], and there were some cases of small-sized breast cancer with relatively intense 18 F-FDG uptake. For this reason, this study was designed to investigate the relationship between clinicopathologic factors for prediction of the aggressiveness of the primary tumor and the intensity of 18 F-FDG in the relatively early T stage of breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with 18F-Fluorodeoxyglucose Uptake in T1 and T2 Invasive Ductal Carcinoma of the Breast

Kim

et al. 2016

Nucl Med Mol Imaging

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Purpose The objective of this study was to investigate the relationship between diversity of 18 F-fluorodeoxyglucose ( 18 F-FDG) uptake of primary tumor in positron emission tomography (PET) and various clinicopathologic factors in breast cancer of same pathologic T1, T2 stage. Methods A total of 258 patients with invasive ductal breast cancer were enrolled in this study. All patients underwent 18 F-FDG PET-CT before surgery. Patients were divided into two groups according to tumor size based on the pathologic T stage, and maximum standardized uptake value (SUVmax) of 2.5, respectively. Results On the univariate analysis, estrogen receptor (ER), tumor size, lymphovascular invasion, p53, pathologic N status (pN) and Nottingham tumor grade (NG) were associated with high SUVmax in T1 and T2 breast cancer. On the multivariate logistic regression, tumor size and NG remained significant variables dividing high and low SUVmax. In the T1 group, ER, p53 and NG were significantly associated with high SUVmax on the univariate analysis. In this group, p53 and NG remained significant variables for dividing high and low SUVmax on the multivariate logistic regression. In the T2 group, only NG was associated with high SUVmax on the univariate analysis.Conclusions NG showed an association with 18 F-FDG uptake in both T1 and T2 breast cancer independently; however, p53 in T1 breast cancer.

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Utility of PET in Breast Cancer

Cited by 46 publications

References 47 publications

Breast Cancer Staging in a Single Session: Whole-Body PET/CT Mammography

Breast Cancer Staging in a Single Session: Whole-Body PET/CT Mammography

Improving Specificity of Breast MRI Using Prone PET and Fused MRI and PET 3D Volume Datasets

Factors Associated with 18F-Fluorodeoxyglucose Uptake in T1 and T2 Invasive Ductal Carcinoma of the Breast

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